Patents Assigned to Affinergy, Inc.
  • Patent number: 8067021
    Abstract: The presently disclosed subject matter relates to a peptide composition for non-covalently localizing fibrous connective tissue-inducing growth factor to a surface of an implant, the composition comprising a peptide having binding affinity for a surface material of an implant coupled to a peptide having binding affinity for a fibrous connective tissue-inducing growth factor. Methods are provided for delivering fibrous connective tissue-inducing growth factor GDF-7 in an amount effective to promote fibrous connective tissue repair and fibrous connective tissue formation. Also provided are methods of applying the peptide composition to an implant by contacting the composition with a surface of the implant; and kits comprising the compositions.
    Type: Grant
    Filed: September 4, 2008
    Date of Patent: November 29, 2011
    Assignee: Affinergy, Inc.
    Inventors: Benjamin Marcus Buehrer, Paul Hamilton, Dalia Juzumiene, Shrikumar Nair, Yuchen Chen
  • Patent number: 7994277
    Abstract: The present invention provides an improved coating for surfaces of medical implants. The coating comprises at least one interfacial biomaterial (IFBM) which is comprised of at least one binding module that binds to the surface of an implant or implant-related material (“implant module”) and at least one binding module that selectively binds to a target analyte or that is designed to have a desired effect (“analyte module”). The modules are connected by a linker. In some embodiments, the IFBM coating acts to promote the recognition and attachment of target analytes to surface of the device. The IFBM coating improves the performance of implanted medical devices, for example, by promoting osteointegration of the implant.
    Type: Grant
    Filed: August 30, 2010
    Date of Patent: August 9, 2011
    Assignee: Affinergy, Inc.
    Inventors: Wayne F. Beyer, Jr., Robin Hyde-DeRuyscher, Paul T. Hamilton, Ray Edward Benson
  • Patent number: 7977313
    Abstract: Compositions are provided comprising a family of peptides having binding specificity for bone, and their use to produce coating compositions. The coating compositions are used to deliver a pharmaceutically active agent to bone, and are used in methods related to bone implants, bone repair, and bone-related diseases.
    Type: Grant
    Filed: April 22, 2008
    Date of Patent: July 12, 2011
    Assignees: Affinergy, Inc., Synthes USA, LLC
    Inventors: Hanne Gron, David Duffin, Doug Buechter, Elliott Gruskin, Michael Lehmicke
  • Patent number: 7972615
    Abstract: The presently disclosed subject matter provides compositions comprising a first substrate-binding domain (a peptide or a polymer) having binding affinity for a tissue or a medical device, a second substrate-binding domain having binding affinity for a target molecule, and the target molecule. In some embodiments, the first and second substrate-binding domains are covalently linked. The first and second substrate-binding domains are covalently coupled to at least one hydrophobic interaction tag, negatively charged interaction tag, or positively charged interaction tag. When the substrate-binding domains are combined and coated onto the tissue or medical device, the hydrophobic interaction tags interact with each other and the charged interaction tags interact with the oppositely charged interaction tags or the oppositely charged substrate binding polymers, to form a macromolecular network of non-covalently coupled substrate-binding domains to load the target molecule onto the tissue or medical device.
    Type: Grant
    Filed: March 27, 2009
    Date of Patent: July 5, 2011
    Assignee: Affinergy, Inc.
    Inventors: Guy Orgambide, Mohmed Anwer, Shrikumar A. Nair, Paul Hamilton
  • Patent number: 7968677
    Abstract: The present invention provides an improved coating for surfaces of medical implants. The coating comprises at least one interfacial biomaterial (IFBM) which is comprised of at least one binding module that binds to the surface of an implant or implant-related material (“implant module”) and at least one binding module that selectively binds to a target analyte or that is designed to have a desired effect (“analyte module”). The modules are connected by a linker. In some embodiments, the IFBM coating acts to promote the recognition and attachment of target analytes to surface of the device. The IFBM coating improves the performance of implanted medical devices, for example, by promoting osteointegration of the implant.
    Type: Grant
    Filed: August 31, 2010
    Date of Patent: June 28, 2011
    Assignee: Affinergy, Inc.
    Inventors: Wayne F. Beyer, Jr., Robin Hyde-DeRuyscher, Paul T. Hamilton, Ray Edward Benson
  • Publication number: 20110038912
    Abstract: The presently disclosed subject matter relates to peptides having binding affinity for glycopeptide antibiotics and methods and compositions for delivering glycopeptide antibiotic to the surface of medical devices. The peptide compositions can comprise a peptide having binding affinity for a surface material of a medical device that is coupled to the peptide having binding affinity for glycopeptide antibiotic. Also provided are methods of applying the peptide compositions to a medical device by contacting the peptide compositions with a surface of the medical device. In addition, kits are provided comprising the peptide compositions.
    Type: Application
    Filed: October 17, 2008
    Publication date: February 17, 2011
    Applicants: Affinergy Inc., Synthes USA, LLC
    Inventors: Martyn K. Darby, Isaac G. Sanford, R. Edward Benson, Hanne Gron, Paul T. Hamilton, Shrikumar A. Nair, Doug Buechter, Elliott Gruskin
  • Patent number: 7812119
    Abstract: The present invention provides an improved coating for surfaces of medical implants. The coating comprises at least one interfacial biomaterial (IFBM) which is comprised of at least one binding module that binds to the surface of an implant or implant-related material (“implant module”) and at least one binding module that selectively binds to a target analyte or that is designed to have a desired effect (“analyte module”). The modules are connected by a linker. In some embodiments, the IFBM coating acts to promote the recognition and attachment of target analytes to surface of the device. The IFBM coating improves the performance of implanted medical devices, for example, by promoting osteointegration of the implant.
    Type: Grant
    Filed: June 19, 2009
    Date of Patent: October 12, 2010
    Assignee: Affinergy, Inc.
    Inventors: Wayne F. Beyer, Jr., Robin Hyde-DeRuyscher, Paul T. Hamilton, Ray Edward Benson
  • Patent number: 7807624
    Abstract: The present invention provides compositions and methods for an improved coating for medical devices. Provided is a biofunctional coating composition comprising at least one binding domain that has binding specificity for a surface material of a medical device, and at least one binding domain that has binding specificity for cells of endothelial cell lineage. Methods for coating a surface of a medical device, and for manufacturing of a medical device, comprise contacting the surface to be coated with the biofunctional coating material in an amount effective to form a coating, and may further comprise contacting the coated surface with cells of endothelial cell lineage to bind the cells of endothelial cell lineage to the coated surface.
    Type: Grant
    Filed: January 5, 2007
    Date of Patent: October 5, 2010
    Assignee: Affinergy, Inc.
    Inventors: Daniel James Kenan, Paul Theodore Hamilton
  • Patent number: 7795383
    Abstract: The present invention provides an improved coating for surfaces of medical implants. The coating comprises at least one interfacial biomaterial (IFBM) which is comprised of at least one binding module that binds to the surface of an implant or implant-related material (“implant module”) and at least one binding module that selectively binds to a target analyte or that is designed to have a desired effect (“analyte module”). The modules are connected by a linker. In some embodiments, the IFBM coating acts to promote the recognition and attachment of target analytes to surface of the device. The IFBM coating improves the performance of implanted medical devices, for example, by promoting osteointegration of the implant.
    Type: Grant
    Filed: June 17, 2009
    Date of Patent: September 14, 2010
    Assignee: Affinergy, Inc.
    Inventors: Wayne F. Beyer, Jr., Robin Hyde-DeRuyscher, Paul T. Hamilton, Ray Edward Benson
  • Patent number: 7790844
    Abstract: The present invention provides an improved coating for surfaces of medical implants. The coating comprises at least one interfacial biomaterial (IFBM) which is comprised of at least one binding module that binds to the surface of an implant or implant-related material (“implant module”) and at least one binding module that selectively binds to a target analyte or that is designed to have a desired effect (“analyte module”). The modules are connected by a linker. In some embodiments, the IFBM coating acts to promote the recognition and attachment of target analytes to surface of the device. The IFBM coating improves the performance of implanted medical devices, for example, by promoting osteointegration of the implant.
    Type: Grant
    Filed: June 17, 2009
    Date of Patent: September 7, 2010
    Assignee: Affinergy, Inc.
    Inventors: Wayne F. Beyer, Jr., Robin Hyde-DeRuyscher, Paul T. Hamilton, Ray Edward Benson
  • Patent number: 7786256
    Abstract: The present invention provides an improved coating for surfaces of medical implants. The coating comprises at least one interfacial biomaterial (IFBM) which is comprised of at least one binding module that binds to the surface of an implant or implant-related material (“implant module”) and at least one binding module that selectively binds to a target analyte or that is designed to have a desired effect (“analyte module”). The modules are connected by a linker. In some embodiments, the IFBM coating acts to promote the recognition and attachment of target analytes to surface of the device. The IFBM coating improves the performance of implanted medical devices, for example, by promoting osteointegration of the implant.
    Type: Grant
    Filed: June 18, 2009
    Date of Patent: August 31, 2010
    Assignee: Affinergy, Inc.
    Inventors: Wayne F. Beyer, Jr., Robin Hyde-DeRuyscher, Paul T. Hamilton, Ray Edward Benson
  • Publication number: 20100098737
    Abstract: The presently disclosed subject matter relates to peptides having binding affinity for glycopeptide antibiotics and methods and compositions for delivering glycopeptide antibiotic to the surface of medical devices. The peptide compositions can comprise a peptide having binding affinity for a surface material of a medical device that is coupled to the peptide having binding affinity for glycopeptide antibiotic. Also provided are methods of applying the peptide compositions to a medical device by contacting the peptide compositions with a surface of the medical device. In addition, kits are provided comprising the peptide compositions.
    Type: Application
    Filed: October 17, 2008
    Publication date: April 22, 2010
    Applicant: Affinergy, Inc.
    Inventors: Martyn Kerry Darby, Isaac Gilliam Sanford, Ray Edward Benson, III, Hanne Gron, Paul Theodore Hamilton, Shrikumar Ambujakshan Nair
  • Patent number: 7608581
    Abstract: The present invention provides compositions and methods for an improved coating for medical devices. Provided is an interfacial biomaterial or biofunctional coating composition comprising at least one binding domain that has bind specificity for a surface material of a medical device, and at least one binding domain that has binding specificity for an antimicrobial composition. Methods for coating a surface of a medical device, and for manufacturing of a medical device, comprise contacting the surface to be coated with the biofunctional coating material in an amount effective to form a coating.
    Type: Grant
    Filed: December 14, 2006
    Date of Patent: October 27, 2009
    Assignee: Affinergy, Inc.
    Inventors: Paul Hamilton, Daniel Kenan, Mark Grinstaff
  • Patent number: 7531505
    Abstract: The present invention provides compositions and methods for an improved coating for medical devices. Provided is a biofunctional coating composition comprising at least one binding domain that has binding specificity for a metallic surface material of a medical device, and at least one binding domain that has binding specificity for cells of endothelial cell lineage. Methods for coating a metallic surface of a medical device, and for manufacturing of a medical device, comprise contacting the metallic surface to be coated with the biofunctional coating material in an amount effective to form a coating, and may further comprise contacting the coated surface with cells of endothelial cell lineage to bind the cells of endothelial cell lineage to the coated surface.
    Type: Grant
    Filed: January 5, 2007
    Date of Patent: May 12, 2009
    Assignee: Affinergy, Inc.
    Inventors: Paul Theodore Hamilton, Daniel James Kenan, Amy Katherine Solan
  • Publication number: 20090098175
    Abstract: The presently disclosed subject matter relates to a peptide composition for non-covalently localizing fibrous connective tissue-inducing growth factor to a surface of an implant, the composition comprising a peptide having binding affinity for a surface material of an implant coupled to a peptide having binding affinity for a fibrous connective tissue-inducing growth factor. Methods are provided for delivering fibrous connective tissue-inducing growth factor GDF-7 in an amount effective to promote fibrous connective tissue repair and fibrous connective tissue formation. Also provided are methods of applying the peptide composition to an implant by contacting the composition with a surface of the implant; and kits comprising the compositions.
    Type: Application
    Filed: September 4, 2008
    Publication date: April 16, 2009
    Applicant: Affinergy, Inc.
    Inventors: Benjamin Marcus Buehrer, Paul Theodore Hamilton, Dalia Izolda Juzumiene, Shrikumar Ambujakshan Nair, Yuchen Chen
  • Publication number: 20060234210
    Abstract: A filter and method for removing selected materials from a biological fluid sample are provided. The filter comprises an outer housing, inlet, and outlet. A plurality of filter surfaces are provided within the outer housing, and at least one coating is applied to the filter surfaces. The at least one coating comprises at least two binding modules that are in turn selectively bound to one another. One binding module is selectively bound to the filter surfaces and another binding module is configured to bind selectively to the selected materials that are to be removed from the fluid sample. As the fluid sample is allowed to pass through the inlet, outer housing, and outlet, the selected materials are selectively bound to the filter surfaces via the coating, thus producing a filtered product at the outlet.
    Type: Application
    Filed: April 13, 2005
    Publication date: October 19, 2006
    Applicant: Affinergy, Inc.
    Inventors: Daniel Kenan, Dale Christensen, Mark Grinstaff
  • Publication number: 20060051395
    Abstract: The present invention provides an improved coating for surfaces of medical implants. The coating comprises at least one interfacial biomaterial (IFBM) which is comprised of at least one binding module that binds to the surface of an implant or implant-related material (“implant module”) and at least one binding module that selectively binds to a target analyte or that is designed to have a desired effect (“analyte module”). The modules are connected by a linker. In some embodiments, the IFBM coating acts to promote the recognition and attachment of target analytes to surface of the device. The IFBM coating improves the performance of implanted medical devices, for example, by promoting osteointegration of the implant.
    Type: Application
    Filed: June 15, 2005
    Publication date: March 9, 2006
    Applicant: Affinergy, Inc.
    Inventors: Wayne Beyer, Robin Hyde-DeRuyscher, Paul Hamilton, Ray Benson
  • Publication number: 20060051396
    Abstract: The present invention provides compositions and methods for an improved coating for medical devices. The coating is an interfacial biomaterial (“IFBM”) which comprises at least one binding module that binds to the surface of a device (“surface-binding module”) and at least one binding module that performs another function (“affector module”) and which acts to inhibit biofilm formation.
    Type: Application
    Filed: June 15, 2005
    Publication date: March 9, 2006
    Applicant: Affinergy, Inc.
    Inventors: Paul Hamilton, Mark Grinstaff, Daniel Kenan, Dale Christensen