Patents Assigned to Affinergy, Inc.
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Patent number: 8067021Abstract: The presently disclosed subject matter relates to a peptide composition for non-covalently localizing fibrous connective tissue-inducing growth factor to a surface of an implant, the composition comprising a peptide having binding affinity for a surface material of an implant coupled to a peptide having binding affinity for a fibrous connective tissue-inducing growth factor. Methods are provided for delivering fibrous connective tissue-inducing growth factor GDF-7 in an amount effective to promote fibrous connective tissue repair and fibrous connective tissue formation. Also provided are methods of applying the peptide composition to an implant by contacting the composition with a surface of the implant; and kits comprising the compositions.Type: GrantFiled: September 4, 2008Date of Patent: November 29, 2011Assignee: Affinergy, Inc.Inventors: Benjamin Marcus Buehrer, Paul Hamilton, Dalia Juzumiene, Shrikumar Nair, Yuchen Chen
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Patent number: 7994277Abstract: The present invention provides an improved coating for surfaces of medical implants. The coating comprises at least one interfacial biomaterial (IFBM) which is comprised of at least one binding module that binds to the surface of an implant or implant-related material (“implant module”) and at least one binding module that selectively binds to a target analyte or that is designed to have a desired effect (“analyte module”). The modules are connected by a linker. In some embodiments, the IFBM coating acts to promote the recognition and attachment of target analytes to surface of the device. The IFBM coating improves the performance of implanted medical devices, for example, by promoting osteointegration of the implant.Type: GrantFiled: August 30, 2010Date of Patent: August 9, 2011Assignee: Affinergy, Inc.Inventors: Wayne F. Beyer, Jr., Robin Hyde-DeRuyscher, Paul T. Hamilton, Ray Edward Benson
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Patent number: 7977313Abstract: Compositions are provided comprising a family of peptides having binding specificity for bone, and their use to produce coating compositions. The coating compositions are used to deliver a pharmaceutically active agent to bone, and are used in methods related to bone implants, bone repair, and bone-related diseases.Type: GrantFiled: April 22, 2008Date of Patent: July 12, 2011Assignees: Affinergy, Inc., Synthes USA, LLCInventors: Hanne Gron, David Duffin, Doug Buechter, Elliott Gruskin, Michael Lehmicke
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Patent number: 7972615Abstract: The presently disclosed subject matter provides compositions comprising a first substrate-binding domain (a peptide or a polymer) having binding affinity for a tissue or a medical device, a second substrate-binding domain having binding affinity for a target molecule, and the target molecule. In some embodiments, the first and second substrate-binding domains are covalently linked. The first and second substrate-binding domains are covalently coupled to at least one hydrophobic interaction tag, negatively charged interaction tag, or positively charged interaction tag. When the substrate-binding domains are combined and coated onto the tissue or medical device, the hydrophobic interaction tags interact with each other and the charged interaction tags interact with the oppositely charged interaction tags or the oppositely charged substrate binding polymers, to form a macromolecular network of non-covalently coupled substrate-binding domains to load the target molecule onto the tissue or medical device.Type: GrantFiled: March 27, 2009Date of Patent: July 5, 2011Assignee: Affinergy, Inc.Inventors: Guy Orgambide, Mohmed Anwer, Shrikumar A. Nair, Paul Hamilton
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Patent number: 7968677Abstract: The present invention provides an improved coating for surfaces of medical implants. The coating comprises at least one interfacial biomaterial (IFBM) which is comprised of at least one binding module that binds to the surface of an implant or implant-related material (“implant module”) and at least one binding module that selectively binds to a target analyte or that is designed to have a desired effect (“analyte module”). The modules are connected by a linker. In some embodiments, the IFBM coating acts to promote the recognition and attachment of target analytes to surface of the device. The IFBM coating improves the performance of implanted medical devices, for example, by promoting osteointegration of the implant.Type: GrantFiled: August 31, 2010Date of Patent: June 28, 2011Assignee: Affinergy, Inc.Inventors: Wayne F. Beyer, Jr., Robin Hyde-DeRuyscher, Paul T. Hamilton, Ray Edward Benson
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Publication number: 20110038912Abstract: The presently disclosed subject matter relates to peptides having binding affinity for glycopeptide antibiotics and methods and compositions for delivering glycopeptide antibiotic to the surface of medical devices. The peptide compositions can comprise a peptide having binding affinity for a surface material of a medical device that is coupled to the peptide having binding affinity for glycopeptide antibiotic. Also provided are methods of applying the peptide compositions to a medical device by contacting the peptide compositions with a surface of the medical device. In addition, kits are provided comprising the peptide compositions.Type: ApplicationFiled: October 17, 2008Publication date: February 17, 2011Applicants: Affinergy Inc., Synthes USA, LLCInventors: Martyn K. Darby, Isaac G. Sanford, R. Edward Benson, Hanne Gron, Paul T. Hamilton, Shrikumar A. Nair, Doug Buechter, Elliott Gruskin
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Patent number: 7812119Abstract: The present invention provides an improved coating for surfaces of medical implants. The coating comprises at least one interfacial biomaterial (IFBM) which is comprised of at least one binding module that binds to the surface of an implant or implant-related material (“implant module”) and at least one binding module that selectively binds to a target analyte or that is designed to have a desired effect (“analyte module”). The modules are connected by a linker. In some embodiments, the IFBM coating acts to promote the recognition and attachment of target analytes to surface of the device. The IFBM coating improves the performance of implanted medical devices, for example, by promoting osteointegration of the implant.Type: GrantFiled: June 19, 2009Date of Patent: October 12, 2010Assignee: Affinergy, Inc.Inventors: Wayne F. Beyer, Jr., Robin Hyde-DeRuyscher, Paul T. Hamilton, Ray Edward Benson
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Patent number: 7807624Abstract: The present invention provides compositions and methods for an improved coating for medical devices. Provided is a biofunctional coating composition comprising at least one binding domain that has binding specificity for a surface material of a medical device, and at least one binding domain that has binding specificity for cells of endothelial cell lineage. Methods for coating a surface of a medical device, and for manufacturing of a medical device, comprise contacting the surface to be coated with the biofunctional coating material in an amount effective to form a coating, and may further comprise contacting the coated surface with cells of endothelial cell lineage to bind the cells of endothelial cell lineage to the coated surface.Type: GrantFiled: January 5, 2007Date of Patent: October 5, 2010Assignee: Affinergy, Inc.Inventors: Daniel James Kenan, Paul Theodore Hamilton
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Patent number: 7795383Abstract: The present invention provides an improved coating for surfaces of medical implants. The coating comprises at least one interfacial biomaterial (IFBM) which is comprised of at least one binding module that binds to the surface of an implant or implant-related material (“implant module”) and at least one binding module that selectively binds to a target analyte or that is designed to have a desired effect (“analyte module”). The modules are connected by a linker. In some embodiments, the IFBM coating acts to promote the recognition and attachment of target analytes to surface of the device. The IFBM coating improves the performance of implanted medical devices, for example, by promoting osteointegration of the implant.Type: GrantFiled: June 17, 2009Date of Patent: September 14, 2010Assignee: Affinergy, Inc.Inventors: Wayne F. Beyer, Jr., Robin Hyde-DeRuyscher, Paul T. Hamilton, Ray Edward Benson
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Patent number: 7790844Abstract: The present invention provides an improved coating for surfaces of medical implants. The coating comprises at least one interfacial biomaterial (IFBM) which is comprised of at least one binding module that binds to the surface of an implant or implant-related material (“implant module”) and at least one binding module that selectively binds to a target analyte or that is designed to have a desired effect (“analyte module”). The modules are connected by a linker. In some embodiments, the IFBM coating acts to promote the recognition and attachment of target analytes to surface of the device. The IFBM coating improves the performance of implanted medical devices, for example, by promoting osteointegration of the implant.Type: GrantFiled: June 17, 2009Date of Patent: September 7, 2010Assignee: Affinergy, Inc.Inventors: Wayne F. Beyer, Jr., Robin Hyde-DeRuyscher, Paul T. Hamilton, Ray Edward Benson
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Patent number: 7786256Abstract: The present invention provides an improved coating for surfaces of medical implants. The coating comprises at least one interfacial biomaterial (IFBM) which is comprised of at least one binding module that binds to the surface of an implant or implant-related material (“implant module”) and at least one binding module that selectively binds to a target analyte or that is designed to have a desired effect (“analyte module”). The modules are connected by a linker. In some embodiments, the IFBM coating acts to promote the recognition and attachment of target analytes to surface of the device. The IFBM coating improves the performance of implanted medical devices, for example, by promoting osteointegration of the implant.Type: GrantFiled: June 18, 2009Date of Patent: August 31, 2010Assignee: Affinergy, Inc.Inventors: Wayne F. Beyer, Jr., Robin Hyde-DeRuyscher, Paul T. Hamilton, Ray Edward Benson
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Publication number: 20100098737Abstract: The presently disclosed subject matter relates to peptides having binding affinity for glycopeptide antibiotics and methods and compositions for delivering glycopeptide antibiotic to the surface of medical devices. The peptide compositions can comprise a peptide having binding affinity for a surface material of a medical device that is coupled to the peptide having binding affinity for glycopeptide antibiotic. Also provided are methods of applying the peptide compositions to a medical device by contacting the peptide compositions with a surface of the medical device. In addition, kits are provided comprising the peptide compositions.Type: ApplicationFiled: October 17, 2008Publication date: April 22, 2010Applicant: Affinergy, Inc.Inventors: Martyn Kerry Darby, Isaac Gilliam Sanford, Ray Edward Benson, III, Hanne Gron, Paul Theodore Hamilton, Shrikumar Ambujakshan Nair
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Patent number: 7608581Abstract: The present invention provides compositions and methods for an improved coating for medical devices. Provided is an interfacial biomaterial or biofunctional coating composition comprising at least one binding domain that has bind specificity for a surface material of a medical device, and at least one binding domain that has binding specificity for an antimicrobial composition. Methods for coating a surface of a medical device, and for manufacturing of a medical device, comprise contacting the surface to be coated with the biofunctional coating material in an amount effective to form a coating.Type: GrantFiled: December 14, 2006Date of Patent: October 27, 2009Assignee: Affinergy, Inc.Inventors: Paul Hamilton, Daniel Kenan, Mark Grinstaff
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Patent number: 7531505Abstract: The present invention provides compositions and methods for an improved coating for medical devices. Provided is a biofunctional coating composition comprising at least one binding domain that has binding specificity for a metallic surface material of a medical device, and at least one binding domain that has binding specificity for cells of endothelial cell lineage. Methods for coating a metallic surface of a medical device, and for manufacturing of a medical device, comprise contacting the metallic surface to be coated with the biofunctional coating material in an amount effective to form a coating, and may further comprise contacting the coated surface with cells of endothelial cell lineage to bind the cells of endothelial cell lineage to the coated surface.Type: GrantFiled: January 5, 2007Date of Patent: May 12, 2009Assignee: Affinergy, Inc.Inventors: Paul Theodore Hamilton, Daniel James Kenan, Amy Katherine Solan
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Publication number: 20090098175Abstract: The presently disclosed subject matter relates to a peptide composition for non-covalently localizing fibrous connective tissue-inducing growth factor to a surface of an implant, the composition comprising a peptide having binding affinity for a surface material of an implant coupled to a peptide having binding affinity for a fibrous connective tissue-inducing growth factor. Methods are provided for delivering fibrous connective tissue-inducing growth factor GDF-7 in an amount effective to promote fibrous connective tissue repair and fibrous connective tissue formation. Also provided are methods of applying the peptide composition to an implant by contacting the composition with a surface of the implant; and kits comprising the compositions.Type: ApplicationFiled: September 4, 2008Publication date: April 16, 2009Applicant: Affinergy, Inc.Inventors: Benjamin Marcus Buehrer, Paul Theodore Hamilton, Dalia Izolda Juzumiene, Shrikumar Ambujakshan Nair, Yuchen Chen
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Publication number: 20060234210Abstract: A filter and method for removing selected materials from a biological fluid sample are provided. The filter comprises an outer housing, inlet, and outlet. A plurality of filter surfaces are provided within the outer housing, and at least one coating is applied to the filter surfaces. The at least one coating comprises at least two binding modules that are in turn selectively bound to one another. One binding module is selectively bound to the filter surfaces and another binding module is configured to bind selectively to the selected materials that are to be removed from the fluid sample. As the fluid sample is allowed to pass through the inlet, outer housing, and outlet, the selected materials are selectively bound to the filter surfaces via the coating, thus producing a filtered product at the outlet.Type: ApplicationFiled: April 13, 2005Publication date: October 19, 2006Applicant: Affinergy, Inc.Inventors: Daniel Kenan, Dale Christensen, Mark Grinstaff
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Publication number: 20060051395Abstract: The present invention provides an improved coating for surfaces of medical implants. The coating comprises at least one interfacial biomaterial (IFBM) which is comprised of at least one binding module that binds to the surface of an implant or implant-related material (“implant module”) and at least one binding module that selectively binds to a target analyte or that is designed to have a desired effect (“analyte module”). The modules are connected by a linker. In some embodiments, the IFBM coating acts to promote the recognition and attachment of target analytes to surface of the device. The IFBM coating improves the performance of implanted medical devices, for example, by promoting osteointegration of the implant.Type: ApplicationFiled: June 15, 2005Publication date: March 9, 2006Applicant: Affinergy, Inc.Inventors: Wayne Beyer, Robin Hyde-DeRuyscher, Paul Hamilton, Ray Benson
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Publication number: 20060051396Abstract: The present invention provides compositions and methods for an improved coating for medical devices. The coating is an interfacial biomaterial (“IFBM”) which comprises at least one binding module that binds to the surface of a device (“surface-binding module”) and at least one binding module that performs another function (“affector module”) and which acts to inhibit biofilm formation.Type: ApplicationFiled: June 15, 2005Publication date: March 9, 2006Applicant: Affinergy, Inc.Inventors: Paul Hamilton, Mark Grinstaff, Daniel Kenan, Dale Christensen