Abstract: In part, the present disclosure is directed to prodrug derivatives of (E)-N-methyl-N-((3-methylbenzofuran-2-yl)methyl)-3-(7-oxo-5,6,7,8-tetrahydro-1, 8-naphthyridin-3-yl)acrylamide compounds with significant solubility and bioavailability profiles.
Type:
Application
Filed:
August 26, 2013
Publication date:
February 20, 2014
Applicant:
AFFINIUM PHARMACEUTICALS, INC.
Inventors:
John J. Partridge, John Colucci, Yves Gareau, Michel Therien, Robert Zamboni, Barry Hafkin, Anthony Marfat, Helmi Zaghdane
Abstract: In part, the present invention is directed to antibacterial compounds.
Type:
Grant
Filed:
June 6, 2005
Date of Patent:
May 28, 2013
Assignee:
Affinium Pharmaceuticals, Inc.
Inventors:
Bruce J. Sargent, Henry Pauls, Judd M. Berman, Jailall Ramnauth, Peter Sampson, Andras Toro, Fernando J. Martin, Matthew D. Surman, Helene Y. Decornez, David D. Manning
Abstract: In part, the present invention is directed to compositions having a FabI inhibitor and at least one other bioactive agent. In another part, the present invention is directed to antibacterial compositions having a compound of formulas I-III and at least one other antibacterial agent.
Type:
Grant
Filed:
September 19, 2005
Date of Patent:
February 1, 2011
Assignee:
Affinium Pharmaceuticals, Inc.
Inventors:
Judd M. Berman, Molly B. Schmid, John D. Mendlein, Nachum Kaplan
Abstract: The present invention relates to novel drug targets for pathogenic bacteria. Accordingly, the invention provides purified protein comprising the amino acid sequence set forth in SEQ ID NO: 4. The invention also provides biochemical and biophysical characteristics of the polypeptides of the invention.
Type:
Grant
Filed:
January 11, 2006
Date of Patent:
September 21, 2010
Assignee:
Affinium Pharmaceuticals, Inc.
Inventors:
Donald E. Awrey, Teresa Clarke McGrath, Vladimir Romanov
Abstract: In part, the present invention is directed to antibacterial compounds of formula (I) wherein A is a bicyclic heteroaryl ring or a tricyclic ring and R2 is an heterocyclic residue; L is a bond, or L is alkyl, alkenyl or cycloalkyl.
Type:
Grant
Filed:
December 5, 2003
Date of Patent:
September 7, 2010
Assignee:
Affinium Pharmaceuticals, Inc.
Inventors:
Judd M. Berman, Peter Sampson, Heinz W. Pauls, Jailall Ramnauth, David Douglas Manning, Matthew D. Surman, Dejian Xie, Helene Y. Decornez
Abstract: The present invention relates to novel drug targets for pathogenic bacteria. Accordingly, the invention provides purified protein derived from Fransicella tularensis comprising the amino acid sequence set forth in SEQ ID NO: 2. The invention also provides biochemical and biophysical characteristics of the polypeptides of the invention.
Type:
Grant
Filed:
December 28, 2006
Date of Patent:
October 13, 2009
Assignee:
Affinium Pharmaceuticals, Inc.
Inventors:
Judd M. Berman, Molly B. Schmid, Donald E. Awrey, Teresa Clarke, Bryan Beattie, Mandy Dorsey
Abstract: This invention relates to newly identified Staphylococcal polynucleotides, polypeptides encoded by such polynucleotides, the uses of such polynucleotides and polypeptides, as well as the production of such polynucleotides and polypeptides and recombinant host cells transformed with the polynucleotides. This invention also relates to inhibiting the biosynthesis or action of such polynucleotides or polypeptides and to the use of such inhibitors in therapy.
Type:
Grant
Filed:
January 25, 2007
Date of Patent:
September 9, 2008
Assignee:
Affinium Pharmaceuticals, Inc.
Inventors:
Michael T. Black, Martin K. Burnham, Jason C. Fedon, John E. Hodgson, David J. Knowles, Michael A. Lonetto, Richard O. Nicholas, Leslie M. Palmer, Julie M. Pratt, Raymond W. Reichard, Martin Rosenberg, Christopher M. Traini, Judith Ward, Richard L. Warren
Abstract: This invention relates to newly identified Staphylococcal polynucleotides, polypeptides encoded by such polynucleotides, the uses of such polynucleotides and polypeptides, as well as the production of such polynucleotides and polypeptides and recombinant host cells transformed with the polynucleotides. This invention also relates to inhibiting the biosynthesis or action of such polynucleotides or polypeptides and to the use of such inhibitors in therapy.
Type:
Application
Filed:
January 25, 2007
Publication date:
March 27, 2008
Applicant:
Affinium Pharmaceuticals, Inc.
Inventors:
Michael Black, Martin Burnham, Jason Fedon, John Hodgson, David Knowles, Michael Lonetto, Richard Nicholas, Leslie Palmer, Julie Pratt, Raymond Reichard, Martin Rosenberg, Christopher Traini, Judith Ward, Richard Warren