Patents Assigned to Affinium Pharmaceuticals, Inc.
  • Publication number: 20140309191
    Abstract: In part, the present invention is directed to antibacterial compounds and salts thereof.
    Type: Application
    Filed: November 8, 2013
    Publication date: October 16, 2014
    Applicant: Affinium Pharmaceuticals, Inc.
    Inventors: Henry Pauls, Jailall Ramnauth
  • Publication number: 20140107106
    Abstract: In part, the present invention is directed to antibacterial compounds.
    Type: Application
    Filed: April 25, 2013
    Publication date: April 17, 2014
    Applicant: Affinium Pharmaceuticals, Inc.
    Inventor: Affinium Pharmaceuticals, Inc.
  • Publication number: 20140051666
    Abstract: In part, the present disclosure is directed to prodrug derivatives of (E)-N-methyl-N-((3-methylbenzofuran-2-yl)methyl)-3-(7-oxo-5,6,7,8-tetrahydro-1, 8-naphthyridin-3-yl)acrylamide compounds with significant solubility and bioavailability profiles.
    Type: Application
    Filed: August 26, 2013
    Publication date: February 20, 2014
    Applicant: AFFINIUM PHARMACEUTICALS, INC.
    Inventors: John J. Partridge, John Colucci, Yves Gareau, Michel Therien, Robert Zamboni, Barry Hafkin, Anthony Marfat, Helmi Zaghdane
  • Publication number: 20130237523
    Abstract: In part, the present invention is directed to antibacterial compounds.
    Type: Application
    Filed: October 4, 2012
    Publication date: September 12, 2013
    Applicant: AFFINIUM PHARMACEUTICALS, INC.
    Inventors: Heinz W. Pauls, Jailall Ramnauth, Peter Sampson, Andras Toro
  • Publication number: 20130150400
    Abstract: In part, the present invention is directed to antibacterial compounds and salts thereof.
    Type: Application
    Filed: August 9, 2012
    Publication date: June 13, 2013
    Applicant: Affinium Pharmaceuticals, Inc.
    Inventors: Henry Pauls, Jailall Ramnauth
  • Patent number: 8450307
    Abstract: In part, the present invention is directed to antibacterial compounds.
    Type: Grant
    Filed: June 6, 2005
    Date of Patent: May 28, 2013
    Assignee: Affinium Pharmaceuticals, Inc.
    Inventors: Bruce J. Sargent, Henry Pauls, Judd M. Berman, Jailall Ramnauth, Peter Sampson, Andras Toro, Fernando J. Martin, Matthew D. Surman, Helene Y. Decornez, David D. Manning
  • Patent number: 8318720
    Abstract: In part, the present invention is directed to antibacterial compounds.
    Type: Grant
    Filed: July 19, 2007
    Date of Patent: November 27, 2012
    Assignee: Affinium Pharmaceuticals, Inc.
    Inventors: Heinz W. Pauls, Jailall Ramnauth, Peter Sampson, Andras Toro
  • Patent number: 8263613
    Abstract: In part, the present invention is directed to antibacterial compounds and salts thereof.
    Type: Grant
    Filed: February 15, 2008
    Date of Patent: September 11, 2012
    Assignee: Affinium Pharmaceuticals, Inc.
    Inventors: Henry Pauls, Jailall Ramnauth
  • Patent number: 8173646
    Abstract: Compounds of the Formula (I) are disclosed which are Fab I inhibitors and are useful in the treatment of bacterial infections.
    Type: Grant
    Filed: July 6, 2010
    Date of Patent: May 8, 2012
    Assignee: Affinium Pharmaceuticals, Inc.
    Inventors: William H. Miller, Kenneth A. Newlander, Mark A. Seefeld, Irene N. Uzinskas, Walter E. Dewolf, Jr., Dalia R. Jakas
  • Patent number: 8153652
    Abstract: Compounds are disclosed which are Fab I inhibitors and are useful in the treatment bacterial infections.
    Type: Grant
    Filed: April 12, 2010
    Date of Patent: April 10, 2012
    Assignee: Affinium Pharmaceuticals, Inc.
    Inventors: Walter J. Burgess, Dalia R. Jakas, William F. Huffman, William H. Miller, Kenneth A. Newlander, Mark A. Seefeld, Irene N. Uzinskas
  • Patent number: 7879872
    Abstract: In part, the present invention is directed to compositions having a FabI inhibitor and at least one other bioactive agent. In another part, the present invention is directed to antibacterial compositions having a compound of formulas I-III and at least one other antibacterial agent.
    Type: Grant
    Filed: September 19, 2005
    Date of Patent: February 1, 2011
    Assignee: Affinium Pharmaceuticals, Inc.
    Inventors: Judd M. Berman, Molly B. Schmid, John D. Mendlein, Nachum Kaplan
  • Patent number: 7799547
    Abstract: The present invention relates to novel drug targets for pathogenic bacteria. Accordingly, the invention provides purified protein comprising the amino acid sequence set forth in SEQ ID NO: 4. The invention also provides biochemical and biophysical characteristics of the polypeptides of the invention.
    Type: Grant
    Filed: January 11, 2006
    Date of Patent: September 21, 2010
    Assignee: Affinium Pharmaceuticals, Inc.
    Inventors: Donald E. Awrey, Teresa Clarke McGrath, Vladimir Romanov
  • Patent number: 7790716
    Abstract: Compounds of the formula (I) are disclosed which are Fab I inhibitors and are useful in the treatment of bacterial infections.
    Type: Grant
    Filed: March 12, 2009
    Date of Patent: September 7, 2010
    Assignee: Affinium Pharmaceuticals, Inc.
    Inventors: William H. Miller, Kenneth A. Newlander, Mark A. Seefeld, Irene N. Uzinskas, Walter E. Dewolf, Jr., Dalia R. Jakas
  • Patent number: 7790709
    Abstract: In part, the present invention is directed to antibacterial compounds of formula (I) wherein A is a bicyclic heteroaryl ring or a tricyclic ring and R2 is an heterocyclic residue; L is a bond, or L is alkyl, alkenyl or cycloalkyl.
    Type: Grant
    Filed: December 5, 2003
    Date of Patent: September 7, 2010
    Assignee: Affinium Pharmaceuticals, Inc.
    Inventors: Judd M. Berman, Peter Sampson, Heinz W. Pauls, Jailall Ramnauth, David Douglas Manning, Matthew D. Surman, Dejian Xie, Helene Y. Decornez
  • Patent number: 7741339
    Abstract: Compounds are disclosed which are Fab I inhibitors and are useful in the treatment bacterial infections.
    Type: Grant
    Filed: June 25, 2007
    Date of Patent: June 22, 2010
    Assignee: Affinium Pharmaceuticals, Inc.
    Inventors: Walter J. Burgess, Dalia R. Jakas, William F. Huffman, William H. Miller, Kenneth A. Newlander, Mark A. Seefeld, Irene N. Uzinskas
  • Patent number: 7601526
    Abstract: The present invention relates to novel drug targets for pathogenic bacteria. Accordingly, the invention provides purified protein derived from Fransicella tularensis comprising the amino acid sequence set forth in SEQ ID NO: 2. The invention also provides biochemical and biophysical characteristics of the polypeptides of the invention.
    Type: Grant
    Filed: December 28, 2006
    Date of Patent: October 13, 2009
    Assignee: Affinium Pharmaceuticals, Inc.
    Inventors: Judd M. Berman, Molly B. Schmid, Donald E. Awrey, Teresa Clarke, Bryan Beattie, Mandy Dorsey
  • Patent number: 7557125
    Abstract: Compounds of the formula (I) are disclosed which are Fab I inhibitors and are useful in the treatment of bacterial infections.
    Type: Grant
    Filed: December 9, 2004
    Date of Patent: July 7, 2009
    Assignee: Affinium Pharmaceuticals, Inc.
    Inventors: William H. Miller, Kenneth A. Newlander, Mark A. Seefeld, Irene N. Uzinskas, Walter E. DeWolf, Dalia R. Jakas
  • Patent number: 7524843
    Abstract: Compounds of the formula (I) are disclosed which are Fab I inhibitors and are useful in the treatment of bacterial infections.
    Type: Grant
    Filed: July 18, 2007
    Date of Patent: April 28, 2009
    Assignee: Affinium Pharmaceuticals, Inc.
    Inventors: William H. Miller, Kenneth A. Newlander, Mark A. Seefeld, Irene N. Uzinskas, Walter E. Dewolf, Jr., Dalia R. Jakas
  • Patent number: 7422749
    Abstract: This invention relates to newly identified Staphylococcal polynucleotides, polypeptides encoded by such polynucleotides, the uses of such polynucleotides and polypeptides, as well as the production of such polynucleotides and polypeptides and recombinant host cells transformed with the polynucleotides. This invention also relates to inhibiting the biosynthesis or action of such polynucleotides or polypeptides and to the use of such inhibitors in therapy.
    Type: Grant
    Filed: January 25, 2007
    Date of Patent: September 9, 2008
    Assignee: Affinium Pharmaceuticals, Inc.
    Inventors: Michael T. Black, Martin K. Burnham, Jason C. Fedon, John E. Hodgson, David J. Knowles, Michael A. Lonetto, Richard O. Nicholas, Leslie M. Palmer, Julie M. Pratt, Raymond W. Reichard, Martin Rosenberg, Christopher M. Traini, Judith Ward, Richard L. Warren
  • Publication number: 20080076709
    Abstract: This invention relates to newly identified Staphylococcal polynucleotides, polypeptides encoded by such polynucleotides, the uses of such polynucleotides and polypeptides, as well as the production of such polynucleotides and polypeptides and recombinant host cells transformed with the polynucleotides. This invention also relates to inhibiting the biosynthesis or action of such polynucleotides or polypeptides and to the use of such inhibitors in therapy.
    Type: Application
    Filed: January 25, 2007
    Publication date: March 27, 2008
    Applicant: Affinium Pharmaceuticals, Inc.
    Inventors: Michael Black, Martin Burnham, Jason Fedon, John Hodgson, David Knowles, Michael Lonetto, Richard Nicholas, Leslie Palmer, Julie Pratt, Raymond Reichard, Martin Rosenberg, Christopher Traini, Judith Ward, Richard Warren