Abstract: The present invention relates to the use of compounds for producing a medicament for preventing and/or treating atherosclerosis, atherosclerosis risk diseases and atherosclerosis sequelae.
Type:
Application
Filed:
August 8, 2008
Publication date:
November 10, 2011
Applicant:
AFFIRIS AG
Inventors:
Sylvia Brunner, Petra Luehrs, Frank Mattner, Walter Schmidt, Barbara Wittmann
Abstract: The present invention relates to the use of mimotopes in the treatment of ?-Amyloidoses including but not limited to Alzheimer's disease, whereby said mimotopes are able to induce the in vivo formation of antibodies directed to non truncated A?1-40/42, and N-terminally truncated forms A?pE3-40/42, A?3-40/42, A?11-40/42, A?pE11-40/42 and A?14-40/42 without interfering with physiological functions of APP signalling.
Type:
Application
Filed:
June 12, 2009
Publication date:
July 14, 2011
Applicant:
AFFIRIS AG
Inventors:
Markus Mandler, Radmila Santic, Harald Weninger, Edith Kopinits
Abstract: The present invention relates to the use of mimotopes in the treatment of diseases associated with ?-amyloid formation and/or aggregation (?-Amyloidoses) including Alzheimer's disease, whereby said mimotopes are able to induce the in vivo formation of antibodies directed to A?1-40/42, A?pE3-40/42, A?3-40/42 and A?11-40/42.
Type:
Application
Filed:
June 12, 2009
Publication date:
April 28, 2011
Applicant:
AFFIRIS AG
Inventors:
Markus Mandler, Christian Gieffers, Frank Mattner, Andrea Dolischka, Oleksandr Otava
Abstract: The present invention relates to the use of at least one compound comprising the amino acid sequence: (X1)nX2X3PVX4X5X6(X7)m (Formula I), wherein X1 is any amino acid residue, X2 is an amino acid residue selected from the group consisting of aspartic acid (D) and glutamic acid (E).
Type:
Application
Filed:
February 23, 2009
Publication date:
April 21, 2011
Applicant:
AFFIRIS AG
Inventors:
Markus Mandler, Harald Weninger, Radmila Santic, Edith Kopinits
Abstract: The present invention relates to a compound comprising a peptide for treating, preventing and/or ameliorating motor symptoms of Parkinson's disease, said peptide having a binding capacity to an antibody which is specific for an epitope of the amyloid-beta-peptide (A?).
Type:
Application
Filed:
June 12, 2009
Publication date:
April 21, 2011
Applicant:
AFFIRIS AG
Inventors:
Markus Mandler, Frank Mattner, Walter Schmidt