Abstract: Provided are methods for site selective conjugation of an oligonucleotide conjugate to a metal binding protein comprising a metal binding site and for site selective conjugation of a small molecule conjugation compound (SMCoC) to an antibody comprising a metal binding site, metal binding protein conjugates obtainable by said methods, and uses of said metal binding protein conjugates.
Type:
Grant
Filed:
July 8, 2015
Date of Patent:
February 23, 2021
Assignee:
Affycon ApS
Inventors:
Kurt Vesterager Gothelf, Thomas Torring, Christian Bech Rosen, Anne Louise Bank Kodal, Michael Rosholm Mortensen
Abstract: Provided are methods for site selective conjugation of an oligonucleotide conjugate to a metal binding protein comprising a metal binding site and for site selective conjugation of a small molecule conjugation compound (SMCoC) to an antibody comprising a metal binding site, metal binding protein conjugates obtainable by said methods, and uses of said metal binding protein conjugates.
Type:
Application
Filed:
July 8, 2015
Publication date:
December 14, 2017
Applicant:
AFFYCON APS
Inventors:
Kurt Vesterager GOTHELF, Thomas T0RRING, Christian Bech ROSEN, Anne Louise Bank KODAL, Michael Rosholm MORTENSEN