Patents Assigned to Affymax, Inc.
  • Peptides that bind to the erythropoietin receptor
    Patent number: 8729030
    Abstract: The present invention relates to peptide compounds that are agonists of the erythropoietin receptor (EPO-R). The invention also relates to therapeutic methods using such peptide compounds to treat disorders associated with insufficient or defective red blood cell production. Pharmaceutical compositions, which comprise the peptide compounds of the invention, are also provided.
    Type: Grant
    Filed: November 12, 2010
    Date of Patent: May 20, 2014
    Assignee: Affymax, Inc.
    Inventors: Christopher P. Holmes, Qun Yin, Guy Lalonde, Peter J. Schatz, David Tumelty, Palani Balu, Genet Zemede
  • Spacer moiety for poly(ethylene glycol) modified peptide based compounds
    Patent number: 8592365
    Abstract: The present invention relates to a compound comprising a peptide moiety, a spacer moiety and a water-soluble polymer moiety such as a poly(ethylene glycol) moiety. The spacer moiety is between the peptide moiety and the water-soluble polymer moiety. The spacer moiety has the structure: —NH—(CH2)?—[O—(CH2)?]?—O?—(CH2)?—Y— wherein ?, ?, ?, ?, and ? are each integers whose values are independently selected.
    Type: Grant
    Filed: April 4, 2011
    Date of Patent: November 26, 2013
    Assignee: Affymax, Inc.
    Inventors: Christopher P. Holmes, David Tumelty, Qun Yin
  • NOVEL PEPTIDES THAT BIND TO THE ERYTHROPOIETIN RECEPTOR
    Publication number: 20130244939
    Abstract: The present invention relates to peptide compounds that are agonists of the erythropoietin receptor (EPO-R). The invention also relates to therapeutic methods using such peptide compounds to treat disorders associated with insufficient or defective red blood cell production. Pharmaceutical compositions, which comprise the peptide compounds of the invention, are also provided.
    Type: Application
    Filed: November 1, 2012
    Publication date: September 19, 2013
    Applicant: AFFYMAX, INC.
    Inventors: Christopher P. Holmes, Qun Yin, Guy Lalonde, Peter J. Schatz, David Tumelty, Balu Palani, Genet Zemede
  • PEPTIDES THAT BIND TO THE ERYTHROPOIETIN RECEPTOR
    Publication number: 20130130979
    Abstract: The present invention relates to peptide compounds that are agonists of the erythropoietin receptor (EPO-R). The invention also relates to therapeutic methods using such peptide compounds to treat disorders associated with insufficient or defective red blood cell production. Pharmaceutical compositions, which comprise the peptide compounds of the invention, are also provided.
    Type: Application
    Filed: October 18, 2012
    Publication date: May 23, 2013
    Applicant: AFFYMAX, INC.
    Inventor: AFFYMAX, INC.
  • Erythropoitein Receptor Peptide Formulations and Uses
    Publication number: 20130079283
    Abstract: The present invention relates to peptide compounds that are agonists of the erythropoietin receptor (EPO-R). The invention also relates to therapeutic methods using such peptide compounds to treat disorders associated with insufficient or defective red blood cell production. Pharmaceutical compositions, which comprise the peptide compounds of the invention, and dosages are also provided.
    Type: Application
    Filed: November 27, 2012
    Publication date: March 28, 2013
    Applicant: AFFYMAX, INC.
    Inventor: Affymax, Inc.
  • NOVEL PEPTIDES THAT BIND TO THE ERYTHROPOIETIN RECEPTOR
    Publication number: 20130012685
    Abstract: The present invention relates to peptide compounds that are agonists of the erythropoietin receptor (EPO-R). The invention further relates to therapeutic methods using such peptide compounds to treat disorders associated with insufficient or defective red blood cell production. Pharmaceutical compositions, which comprise the peptide compounds of the invention, are also provided.
    Type: Application
    Filed: July 3, 2012
    Publication date: January 10, 2013
    Applicant: AFFYMAX, INC.
    Inventors: Christopher P. Holmes, Qun Yin, Genet Zemede, Ashok Bhandari, Yaohua S. Dong, David Tumelty, Guy Lalonde, Brian T. Frederick, Anjan Chakrabarti, Palani Balu, Peter J. Schatz, Nicholas C. Wrighton, William J. Dower
  • Erythropoietin receptor peptide formulations and uses
    Patent number: 8324159
    Abstract: The present invention relates to peptide compounds that are agonists of the erythropoietin receptor (EPO-R). The invention also relates to therapeutic methods using such peptide compounds to treat disorders associated with insufficient or defective red blood cell production. Pharmaceutical compositions, which comprise the peptide compounds of the invention, and dosages are also provided.
    Type: Grant
    Filed: July 23, 2008
    Date of Patent: December 4, 2012
    Assignee: Affymax, Inc.
    Inventors: Anne-Marie Duliege, Richard Stead, Kerstin Leuther, Kathryn Wynne Woodburn, Robert Barnett Naso
  • Peptides that bind to the erythropoietin receptor
    Patent number: 8304391
    Abstract: Peptide compounds that are agonists of the erythropoietin receptor (EPO-R) are described, as well as therapeutic methods using such peptide compounds to treat disorders associated with insufficient or defective red blood cell production. Pharmaceutical compositions, which comprise the peptide compounds of the invention, are also provided.
    Type: Grant
    Filed: March 17, 2009
    Date of Patent: November 6, 2012
    Assignee: Affymax, Inc.
    Inventors: Christopher P. Holmes, Qun Yin, Guy Lalonde, Peter J. Schatz, David Tumelty, Balu Palani, Genet Zemede
  • Nitrogen-Based Linkers for Attaching Modifying Groups to Polypeptides and Other Macromolecules
    Publication number: 20120165275
    Abstract: Compounds comprising a peptide moiety, a linker moiety and a water-soluble polymer moiety such as a poly(ethylene glycol) moiety are disclosed. Various linker moieties for use in these compounds are also disclosed, along methods for their synthesis.
    Type: Application
    Filed: December 21, 2011
    Publication date: June 28, 2012
    Applicant: AFFYMAX, INC.
    Inventors: Christopher P. Holmes, Anjan Chakrabarti, Brian T. Frederick, Yijun Pan, Yaohua S. Dong, Ashok Bhandari
  • NOVEL PEPTIDES THAT BIND TO THE ERYTHROPOIETIN RECEPTOR
    Publication number: 20120157660
    Abstract: The present invention relates to peptide compounds that are agonists of the erythropoietin receptor (EPO-R). The invention further relates to therapeutic methods using such peptide compounds to treat disorders associated with insufficient or defective red blood cell production. Pharmaceutical compositions, which comprise the peptide compounds of the invention, are also provided.
    Type: Application
    Filed: August 18, 2010
    Publication date: June 21, 2012
    Applicant: AFFYMAX, INC.
    Inventors: Christopher P. Holmes, Qun Yin, Genet Zemede, Ashok Bhandari, David Tumelty, Guy Lalonde, Palani Balu, Peter J. Schatz, William J. Dower, Anjan Chakrabarti, Yaohua S. Dong, Brian T. Frederick, Nicholas C. Wrighton
  • Novel Spacer Moiety for Poly(ehtylene Glycol) Modified Peptide Based Compounds
    Publication number: 20120115796
    Abstract: The present invention relates to a compound comprising a peptide moiety, a spacer moiety and a water-soluble polymer moiety such as a poly(ethylene glycol) moiety. The spacer moiety is between the peptide moiety and the water-soluble polymer moiety. The spacer moiety has the structure: —NH—(CH2)?—[O—(CH2)?]?—O?—(CH2)?—Y— wherein ?, ?, ?, ?, and ? are each integers whose values are independently selected.
    Type: Application
    Filed: April 4, 2011
    Publication date: May 10, 2012
    Applicant: AFFYMAX, INC.
    Inventors: Christopher P. Holmes, David Tumelty, Qun Yin
  • Nitrogen-based linkers for attaching modifying groups to polypeptides and other macromolecules
    Patent number: 8106154
    Abstract: Compounds comprising a peptide moiety, a linker moiety and a water-soluble polymer moiety such as a poly(ethylene glycol) moiety are disclosed. Various linker moieties for use in these compounds are also disclosed, along methods for their synthesis.
    Type: Grant
    Filed: January 30, 2008
    Date of Patent: January 31, 2012
    Assignee: Affymax, Inc.
    Inventors: Christopher P. Holmes, Anjan Chakrabarti, Brian T. Frederick, Yijun Pan, Yaohua S. Dong, Ashok Bhandari
  • NOVEL PEPTIDES THAT BIND TO THE ERYTHROPOIETIN RECEPTOR
    Publication number: 20110282029
    Abstract: The present invention relates to peptide compounds that are agonists of the erythropoietin receptor (EPO-R). The invention further relates to therapeutic methods using such peptide compounds to treat disorders associated with insufficient or defective red blood cell production. Pharmaceutical compositions, which comprise the peptide compounds of the invention, are also provided.
    Type: Application
    Filed: December 10, 2010
    Publication date: November 17, 2011
    Applicant: AFFYMAX, INC.
    Inventors: Christopher P. Holmes, Qun Yin, Genet Zemede, Ashok Bhandari, Yaohua S. Dong, David Tumelty, Guy Lalonde, Brian T. Frederick, Anjan Chakrabarti, Palani Balu, Peter J. Schatz, Nicholas C. Wrighton, William J. Dower
  • NOVEL PEPTIDES THAT BIND TO THE ERYTHROPOIETIN RECEPTOR
    Publication number: 20110245176
    Abstract: The present invention relates to peptide compounds that are agonists of the erythropoietin receptor (EPO-R). The invention also relates to therapeutic methods using such peptide compounds to treat disorders associated with insufficient or defective red blood cell production. Pharmaceutical compositions, which comprise the peptide compounds of the invention, are also provided.
    Type: Application
    Filed: November 12, 2010
    Publication date: October 6, 2011
    Applicant: AFFYMAX, INC.
    Inventors: Christopher P. Holmes, Qun Yin, Guy Lalonde, Peter J. Schatz, David Tumelty, Balu Palani, Genet Zemede
  • Erythropoietin receptor peptide formulations and uses
    Patent number: 7919461
    Abstract: The present invention relates to peptide compounds that are agonists of the erythropoietin receptor (EPO-R). The invention also relates to therapeutic methods using such peptide compounds to treat disorders associated with insufficient or defective red blood cell production. Pharmaceutical compositions, which comprise the peptide compounds of the invention, and dosages are also provided.
    Type: Grant
    Filed: July 13, 2007
    Date of Patent: April 5, 2011
    Assignee: Affymax, Inc.
    Inventors: Anne-Marie Duliege, Richard Stead, Kerstin Leuther, Kathryn Wynne Woodburn, Robert Barnett Naso
  • Erythropoietin receptor peptide formulations and uses
    Patent number: 7906485
    Abstract: The present invention relates to peptide compounds that are agonists of the erythropoietin receptor (EPO-R). The invention also relates to therapeutic methods using such peptide compounds to treat disorders associated with insufficient or defective red blood cell production, including pure red cell aplasia (PRCA). Pharmaceutical compositions, which comprise the peptide compounds of the invention, and dosages are also provided.
    Type: Grant
    Filed: June 5, 2006
    Date of Patent: March 15, 2011
    Assignee: Affymax, Inc.
    Inventors: Anne-Marie Duliege, Richard Stead, Kerstin Leuther, Kathryn Wynne Woodburn, Robert Barnett Naso
  • Peptides that bind to the erythropoietin receptor
    Patent number: 7855175
    Abstract: The present invention relates to peptide compounds that are agonists of the erythropoietin receptor (EPO-R). The invention also relates to therapeutic methods using such peptide compounds to treat disorders associated with insufficient or defective red blood cell production. Pharmaceutical compositions, which comprise the peptide compounds of the invention, are also provided.
    Type: Grant
    Filed: July 11, 2008
    Date of Patent: December 21, 2010
    Assignee: Affymax, Inc.
    Inventors: Christopher P. Holmes, Qun Yin, Guy Lalonde, Peter J. Schatz, David Tumelty, Palani Balu, Genet Zemede
  • PEPTIDES THAT BIND TO THE ERYTHROPOIETIN RECEPTOR
    Publication number: 20090227508
    Abstract: The present invention relates to peptide compounds that are agonists of the erythropoietin receptor (EPO-R). The invention also relates to therapeutic methods using such peptide compounds to treat disorders associated with insufficient or defective red blood cell production. Pharmaceutical compositions, which comprise the peptide compounds of the invention, are also provided.
    Type: Application
    Filed: March 17, 2009
    Publication date: September 10, 2009
    Applicant: Affymax, Inc.
    Inventors: Christopher P. Holmes, Qun Yin, Guy Lalonde, Peter J. Schatz, David Tumelty, Balu Palani, Genet Zemede
  • TREATMENT OF ANTI-ERYTHROPOIETIN ANTIBODY-MEDIATED DISORDERS WITH SYNTHETIC PEPTIDE-BASED EPO RECEPTOR AGONISTS
    Publication number: 20090209457
    Abstract: The present invention relates to peptide compounds that are agonists of the erythropoietin receptor (EPO-R). The invention also relates to therapeutic methods using such peptide compounds to treat or to prevent anti-erythropoietin (EPO) antibody-mediated disorders such as pure red cell aplasia (PRCA) that are characterized by anti-EPO antibodies. Pharmaceutical compositions, which comprise the peptide compounds of the invention, are also provided.
    Type: Application
    Filed: February 13, 2009
    Publication date: August 20, 2009
    Applicant: Affymax, Inc.
    Inventors: Anne-Marie Duliege, Peter J. Schatz, Richard Stead, Kathryn Wynne Woodburn
  • Peptide library and screening systems
    Patent number: 7553617
    Abstract: Peptides which bind to selected receptor molecules are identified by screening libraries which encode a random or controlled collection of amino acids. Peptides encoded by the libraries are expressed as fusion proteins of bacteriophage coat proteins, and bacteriophage particles are then screened against the receptors of interest. Peptides having a wide variety of uses, such as therapeutic or diagnostic reagents, may thus be identified without any prior information on the structure of the expected ligand or receptor molecule.
    Type: Grant
    Filed: August 28, 2000
    Date of Patent: June 30, 2009
    Assignee: Affymax, Inc.
    Inventors: William J. Dower, Steven E. Cwirla