Patents Assigned to Agamatrix, Inc.
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Patent number: 8016997Abstract: A method is provided for determining analyte concentrations, for example glucose concentrations, that utilizes a dynamic determination of the appropriate time for making a glucose measurement, for example when a current versus time curve substantially conforms to a Cottrell decay, or when the current is established in a plateau region. Dynamic determination of the time to take the measurement allows each strip to operate in the shortest appropriate time frame, thereby avoiding using an average measurement time that may be longer than necessary for some strips and too short for others.Type: GrantFiled: January 12, 2010Date of Patent: September 13, 2011Assignee: Agamatrix, Inc.Inventors: Steven Diamond, Ian Harding, Sridhar G. Iyengar, Baoguo Wei
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Publication number: 20110215004Abstract: The ability to switch at will between amperometric measurements and potentiometric measurements provides great flexibility in performing analyses of unknowns. Apparatus and methods can provide such switching to collect data from an electrochemical cell. The cell may contain a reagent disposed to measure glucose in human blood.Type: ApplicationFiled: May 16, 2011Publication date: September 8, 2011Applicant: AGAMATRIX, INC.Inventors: Sonny Vu, Eileen Huang, Joseph Flaherty
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Publication number: 20110173801Abstract: Electrochemical test cells are made with precision and accuracy by adhering an electrically resistive sheet having a bound opening to a first electrically conductive sheet. A notching opening is then punched through the electrically resistive sheet and the first electrically conductive sheet. The notching opening intersects the first bound opening in the electrically resistive sheet, and transforms the first bound opening into a notch in the electrically resistive sheet. A second electrically conductive sheet is punched to have a notching opening corresponding to that of first electrically conductive sheet, and this is adhered to the other side of the electrically resistive sheet such that the notching openings are aligned. This structure is cleaved from surrounding material to form an electrochemical cell that has a sample space for receiving a sample defined by the first and second conductive sheets and the notch in the electrically resistive sheet.Type: ApplicationFiled: March 21, 2011Publication date: July 21, 2011Applicant: AGAMATRIX, INC.Inventors: Ian Harding, Sridhar G. Iyengar, Marina T. Larson, Carl Oppedahl
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Publication number: 20110147210Abstract: Systems and methods are provided herein for improving the selectivity and productivity of sensors via digital signal processing techniques. According to one illustrative embodiment, in an electrochemical method for monitoring of a select analyte in a mixed sample with an interfering analyte, an improvement is provided that includes applying a large amplitude potential stimulus waveform to the sample to generate a nonlinear current signal; and resolving a signal contribution from the select analyte in the generated signal by a vector projection method with an analyte vector comprising a plurality of real and imaginary parts of one or more Fourier coefficients at one or more frequencies of a reference current signal for the select analyte.Type: ApplicationFiled: October 21, 2010Publication date: June 23, 2011Applicant: AGAMATRIX, INC.Inventors: Sridhar G. Iyengar, Daniel Haas, Craig Bolon, Ian Harding
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Patent number: 7964146Abstract: The ability to switch at will between amperometric measurements and potentiometric measurements provides great flexibility in performing analyses of unknowns. Apparatus and methods can provide such switching to collect data from an electrochemical cell. The cell may contain a reagent disposed to measure glucose in human blood.Type: GrantFiled: April 15, 2005Date of Patent: June 21, 2011Assignee: AgaMatrix, Inc.Inventors: Ian Harding, Sridhar G. Iyengar, Baoguo Wei, Sonny Vu, Eileen Huang, Joseph Flaherty, Steven Diamond, Martin Forest
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Patent number: 7964089Abstract: The presence of oxygen or red blood cells in a sample applied to an electrochemical test strip that makes use of a reduced mediator is corrected for by an additive correction factor that is determined as a function of the temperature of the sample and a measurement that reflects the oxygen carrying capacity of the sample. The measured oxygen carrying capacity can also be used to determine hematocrit and to distinguish between blood samples and control solutions applied to a test strip.Type: GrantFiled: April 15, 2005Date of Patent: June 21, 2011Assignee: AgaMatrix, Inc.Inventors: Ian Harding, Richard Williams, Sridhar Iyengar
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Patent number: 7943034Abstract: A method and apparatus for provide a stable voltage to an electrochemical cell used for measurement of an analyte such as glucose in a liquid sample. The apparatus uses a circuit in which multiple switching positions provide both calibration information for use in calibration of electronic components in the circuit and error checking functionality.Type: GrantFiled: October 18, 2007Date of Patent: May 17, 2011Assignee: Agamatrix, Inc.Inventors: Steven Diamond, Martin Forest, Darius Rad, Baoguo Wei
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Publication number: 20110108417Abstract: Bis-(4,4?dimethyl-2,2?bipyridyl) picolinate osmium complexes are useful as mediators in the electrochemical test strips, such as those used in the detection of glucose.Type: ApplicationFiled: January 13, 2011Publication date: May 12, 2011Applicant: AGAMATRIX. INC.Inventor: Ian Harding
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Patent number: 7927345Abstract: A lancet cartridge has a U-shaped support with a pair of anchor portions, a base portion, and a pair of deformable leg portions connecting the anchor portions to the base portion. The pair of deformable leg portions change shape from an initial shape to an extended shape in response to an external applied force and recover to a retracted shape upon removal of the force. The lancet cartridge also has a lancet having a tip end, an opposing base end, and an axis extending between the tip end and the base end. A portion of the lancet is disposed between the pair of deformable leg portions of the U-shaped support. The lancet is movable between a starting position, an extended puncturing position, and an ending position along the axis of the lancet in a path defined by the U-shaped support. When the lancet is in the starting position, the tip end of the lancet is disposed at least partially through the base portion of the U-shaped support, and the U-shaped support is in the initial shape.Type: GrantFiled: November 2, 2006Date of Patent: April 19, 2011Assignee: AgaMatrix, Inc.Inventors: Frederick Berkovitch, Brad Boozer, Joseph Flaherty, Timothy Golnik, Sridhar Iyengar, Malia Kilpinen, Sonny Vu
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Publication number: 20110083974Abstract: A device for measuring blood coagulation time is formed from a first substrate; a second substrate; a spacer layer disposed between the first and second substrates, said spacer layer having an opening formed therein defining a sample receiving chamber, a vented sink chamber, and an elongated reservoir forming a conduit for liquid movement between the sample receiving chamber and the sink chamber; a first electrode disposed on the first substrate, said first electrode being exposed in the reservoir portion through a first opening in the spacer layer; and a second electrode disposed on the second substrate, said second electrode being exposed in the reservoir portion through a second opening in the spacer layer. The device of the invention is used in combination with an apparatus that is connected to the first and second electrodes for measuring current flow between the first and second electrodes.Type: ApplicationFiled: November 16, 2010Publication date: April 14, 2011Applicant: AGAMATRIX, INC.Inventors: Ian Harding, Sridhar G. Iyengar, Ha Nguyen, Richard Williams
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Publication number: 20110073496Abstract: Measurement of the series track resistance of a working and counter electrode pair in an electrochemical test strip provide error detection for multiple variations in the quality of the test strip, as well as the operation of strip in the test meter. In particular, a single measurement of series resistance can be used to detect and generate an error message when an incorrect reading is likely to result due to (1) damaged electrode tracks, (2) fouled electrode surfaces, (3) dirty strip contacts, or (4) short circuit between the electrodes.Type: ApplicationFiled: December 7, 2010Publication date: March 31, 2011Applicant: AGAMATRIX, INC.Inventors: Steven Diamond, Ian Harding, Richard Williams
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Publication number: 20110062033Abstract: Correction for initial variation in thickness of a polymer layer and for changes in the coating thickness that occur after implantation of a biosensor and therefore provides substantial increase in the accuracy and lifetime of implantable sensors is done using a factor derived from the decay of potential.Type: ApplicationFiled: September 15, 2010Publication date: March 17, 2011Applicant: AGAMATRIX, INC.Inventors: Sridhar Iyengar, Ian Harding
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Publication number: 20100308837Abstract: A test strip and analytical apparatus have pin connections permitting the definition of geographic regions or of particular customers. A test strip made for use in a particular region or for a particular customer will have pin connections matching features of the apparatus made for use in that region or by that customer. Insertion of the strip into the apparatus does not merely turn on the apparatus, but provides the regional or customer coding. Analog switches within the apparatus allow coding of a larger number of distinct regions or customers than would otherwise be possible, all without degrading the quality of the measurements made of the fluid being tested. Conductive paths in the strips permit testing the strips during manufacture so as to detect quality lapses regarding the printing or deposition of the paths.Type: ApplicationFiled: May 11, 2010Publication date: December 9, 2010Applicant: AGAMATRIX, INC.Inventors: Steven Diamond, Martin Forest, Baoguo Wei, Ian Harding, Sridhar Iyengar
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Patent number: 7846321Abstract: Measurement of the series track resistance of a working and counter electrode pair in an electrochemical test strip provide error detection for multiple variations in the quality of the test strip, as well as the operation of strip in the test meter. In particular, a single measurement of series resistance can be used to detect and generate an error message when an incorrect reading is likely to result due to (1) damaged electrode tracks, (2) fouled electrode surfaces, (3) dirty strip contacts, or (4) short circuit between the electrodes.Type: GrantFiled: October 18, 2007Date of Patent: December 7, 2010Assignee: Agamatrix, Inc.Inventors: Steven Diamond, Ian Harding, Richard Williams
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Patent number: 7837941Abstract: A device for measuring blood coagulation time is formed from a first substrate; a second substrate; a spacer layer disposed between the first and second substrates, said spacer layer having an opening formed therein defining a sample receiving chamber, a vented sink chamber, and an elongated reservoir forming a conduit for liquid movement between the sample receiving chamber and the sink chamber; a first electrode disposed on the first substrate, said first electrode being exposed in the reservoir portion through a first opening in the spacer layer; and a second electrode disposed on the second substrate, said second electrode being exposed in the reservoir portion through a second opening in the spacer layer. The device of the invention is used in combination with an apparatus that is connected to the first and second electrodes for measuring current flow between the first and second electrodes.Type: GrantFiled: April 7, 2006Date of Patent: November 23, 2010Assignee: AgaMatrix, Inc.Inventors: Ian Harding, Sridhar G. Iyengar, Ha Nguyen, Richard Williams
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Publication number: 20100249965Abstract: The present invention provides a method of transferring data between a diagnostic measurement device and a portable consumer electronic device (CED). The method includes a step of communicatively coupling the diagnostic measurement device and the CED through an audio port located on the CED. The method also includes the step of transferring data from the diagnostic measurement device to the CED through the audio port of the consumer electronic device.Type: ApplicationFiled: March 30, 2010Publication date: September 30, 2010Applicant: AGAMATRIX, INC.Inventors: Anoop Rao, Sonny Vu, Timothy Golnik
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Publication number: 20100219083Abstract: Systems and methods are provided herein for improving the selectivity and productivity of sensors via digital signal processing techniques. According to one illustrative embodiment, in an electrochemical method for monitoring of a select analyte in a mixed sample with an interfering analyte, an improvement is provided that includes applying a large amplitude potential stimulus waveform to the sample to generate a nonlinear current signal; and resolving a signal contribution from the select analyte in the generated signal by a vector projection method with an analyte vector comprising a plurality of real and imaginary parts of one or more Fourier coefficients at one or more frequencies of a reference current signal for the select analyte.Type: ApplicationFiled: July 17, 2006Publication date: September 2, 2010Applicant: AGAMATRIX, INC.Inventors: Sridhar G. Iyengar, Daniel Haas, Craig Bolon
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Patent number: 7771583Abstract: Determination of an analyte with increased accuracy is achieved by electrochemically determining an initial analyte concentration, performing a plurality of amperometric/potentiometric switching cycles, observing a characteristic of the signal during each of the plurality of switching cycles, determining an averaged value for the characteristic of the signal, and correcting the initial measurement value to arrive at a final measurement value of analyte concentration or rejecting the initial measurement value depending on the averaged value of the characteristic of the signal. The characteristic of the signal that is observed is not per se indicative of the amount of analyte present in a sample. Rather, it is a characteristic of the signal that reflects the quality of the electrodes, the extent of fill of the electrochemical cell or characteristics of the sample other than analyte concentration such as oxygen levels or hematocrit.Type: GrantFiled: October 18, 2007Date of Patent: August 10, 2010Assignee: Agamatrix, Inc.Inventors: Steven Diamond, Ian Harding, Sridhar Iyengar, Richard Williams
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Publication number: 20100126881Abstract: A method is provided for determining analyte concentrations, for example glucose concentrations, that utilizes a dynamic determination of the appropriate time for making a glucose measurement, for example when a current versus time curve substantially conforms to a Cottrell decay, or when the current is established in a plateau region. Dynamic determination of the time to take the measurement allows each strip to operate in the shortest appropriate time frame, thereby avoiding using an average measurement time that may be longer than necessary for some strips and too short for others.Type: ApplicationFiled: January 12, 2010Publication date: May 27, 2010Applicant: AGAMATRIX, INC.Inventors: Steven Diamond, Ian Harding, Sridhar G. Iyengar, Baoguo Wei
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Patent number: 7713392Abstract: A test strip and analytical apparatus have pin connections permitting the definition of geographic regions or of particular customers. A test strip made for use in a particular region or for a particular customer will have pin connections matching features of the apparatus made for use in that region or by that customer. Insertion of the strip into the apparatus does not merely turn on the apparatus, but provides the regional or customer coding. Analog switches within the apparatus allow coding of a larger number of distinct regions or customers than would otherwise be possible, all without degrading the quality of the measurements made of the fluid being tested. Conductive paths in the strips permit testing the strips during manufacture so as to detect quality lapses regarding the printing or deposition of the paths.Type: GrantFiled: April 15, 2005Date of Patent: May 11, 2010Assignee: Agamatrix, Inc.Inventors: Ian Harding, Sridhar Iyengar, Baoguo Wei, Steven Diamond, Martin Forest