Patents Assigned to Agena BioScience, Inc.
  • Methods for high level multiplexed polymerase chain reactions and homogeneous mass extension reactions
    Patent number: 9068223
    Abstract: Provided herein are optimized methods for performing multiplexed detection of a plurality of sequence variations. Also provided are methods for performing multiplexed amplification of target nucleic acid.
    Type: Grant
    Filed: December 18, 2012
    Date of Patent: June 30, 2015
    Assignee: Agena Bioscience, Inc.
    Inventors: Martin Beaulieu, Dirk Johannes Van Den Boom
  • Detection and quantification of biomolecules using mass spectrometry
    Patent number: 9051608
    Abstract: The present invention is directed in part to a method for detecting a target nucleic acid using detector oligonucleotides detectable by mass spectrometry. This method takes advantage of the 5? to 3? nuclease activity of a nucleic acid polymerase to cleave annealed oligonucleotide probes from hybridized duplexes and releases labels for detection by mass spectrometry. This process is easily incorporated into a polymerase chain reaction (PCR) amplification assay. The method also includes embodiments directed to quantitative analysis of target nucleic acids.
    Type: Grant
    Filed: February 13, 2013
    Date of Patent: June 9, 2015
    Assignee: AGENA BIOSCIENCE, INC.
    Inventors: Dirk Johannes Van Den Boom, Paul Andrew Oeth, Payam Mahboubi
  • Method and apparatus for delivery of submicroliter volumes onto a substrate
    Patent number: 8999266
    Abstract: A slotted pin tool, a delivery system containing the pin tool, a substrate for use in the system and methods using the pin tool and system are provided. The slotted pin tool contains a plurality of pins having slotted ends designed to fit around each loci of material deposited on a surface, such as a microarray, without contacting any of the deposited material. Sample is delivered by contacting the pin tool with the surface; the amount delivered is proportional to the velocity of the pin tool as it contacts the surface or the velocity of the liquid when movement of the pin is halted.
    Type: Grant
    Filed: November 21, 2012
    Date of Patent: April 7, 2015
    Assignee: Agena BioScience, Inc.
    Inventors: Xian-Wei Yao, Chao Lin, Paul Heaney, Thomas Becker, Aaron A. Hanson, Michael C. Willis
  • Matrix-assisted laser desorption ionization mass spectrometry substrates having low volume matrix array elements
    Patent number: 8821816
    Abstract: Provided herein are substrates for matrix-assisted laser-desorption ionization (MALDI) mass spectrometric analysis. Each spot includes 3-hydroxypicolinic acid matrix and no analyte.
    Type: Grant
    Filed: May 19, 2008
    Date of Patent: September 2, 2014
    Assignee: Agena Biosciences, Inc.
    Inventors: Daniel P. Little, Maryanne J. O'Donnell-Maloney, Charles R. Cantor, Hubert Köster