Abstract: Disclosed is an expression vector comprising a polynucleotide encoding for a glutamine synthetase with reduced activity compared to a wild type glutamine synthetase. Also disclosed are host cells, methods for preparing stable cell line, methods of producing polypeptide of interest, and kits thereof.

Abstract: The present disclosure provides a multiplexed amplification reaction kit for identifying a subject suffering from a malignancy sensitive to treatment with an inhibitor of the Wnt signaling pathway, a method of identifying a subject suffering from a malignancy, a method of identifying sensitivity to an inhibitor of Wnt signaling in a subject suffering from a malignancy, and a method of treating a subject with a malignancy.

Abstract: The invention relates to an isolated polypeptide encoded by Sghrt and related uses. In addition, methods of assessing a heart function, treating impaired heart function by inhibiting Sghrt, identifying a potential drug for treating impaired heart function, and dedifferentiating and/or proliferating a heart cell by inhibiting Sghrt are claimed.

Abstract: A method of spatial modulation using an antenna array including radiating elements having power amplifiers communicatively coupled thereto. An amplitude of an output signal to be formed in space is determined by the antenna array based on an input signal. Output amplitude levels for the radiating elements are determined based on the amplitude of the output signal and a current output amplitude level of the antenna array. The first signal(s) for a first subarray of the antenna array and the second signal(s) for a second subarray of the antenna array are generated based on the input signal. The output amplitude levels are assigned to the power amplifiers of the radiating elements. The first signal(s) are sent to radiating elements of the first subarray and the second signal(s) are sent to radiating elements of the second subarray for transmission therefrom to form a combined signal in space as the output signal.

Abstract: There is provided a method of determining an order of encrypted inputs, including a first encrypted input and a second encrypted input, using at least one processor, the first encrypted input including a first encrypted data and the second encrypted input including a second encrypted data, each of the first and second encrypted data being encrypted based on a homomorphic encryption scheme, the method including: generating a first series of encrypted blocks from the first encrypted data and a second series of encrypted blocks from the second encrypted data; performing a first block-wise operation between the first series of encrypted blocks and the second series of encrypted blocks to obtain a first series of block-wise outputs; performing a second block-wise operation between the first series of encrypted blocks and the second series of encrypted blocks to obtain a second series of block-wise outputs; and determining an order of the first and second encrypted data based on the first series of block-wise outpu

Abstract: There is provided a polymer composition comprising at least one (meth)acrylate monomer or oligomer, a phase separating agent, a photoinitiator and a photosensitizer. There is also provided a method of preparing a polymer resin comprising the step of polymerizing a solution of at least one (meth)acrylate polymer or oligomer, a photoinitiator, a photosensitizer and a phase separating agent in the presence of UV light to form the polymer resin. There is also provided a polymer resin and uses of the polymer composition.

Abstract: “Herein disclosed is an ex vivo method of identifying a state of a tumor margin in a sample. The method comprises operating a system to generate an ultrasound image and a photoacoustic image, wherein the system comprises: a probe configured to deliver a pulsed laser from a laser source to a sample, wherein the laser source is operable to generate the pulsed laser; arrays coupled to the probe, wherein one of the arrays comprises transducing elements arranged thereon which are operable to transmit and collect ultrasound signals, and wherein one of the arrays comprises transducing elements arranged thereon which are operable to collect photoacoustic signals; and a data acquisition module which converts the ultrasound signals and the photoacoustic signals into the ultrasound image and the photoacoustic image, respectively.

Abstract: There is provided a lighting system comprising a light source, and a cooling system with temperature sensing and responding capability coupled to the light source for maintaining a temperature of the light source within a defined variation from a set temperature. There are also provided a method of adjusting a temperature of a light source and a method of assembling the lighting system. There is further provided an additive manufacturing system for three-dimensional printing comprising the lighting system.

Abstract: Photocurable compositions comprising 20-90% by weight of a polymerizable core resin; 20-90% by weight of a diluent resin miscible with said core resin; and at least about 1% by weight of at least one rheology modifier which is distinct from said diluent resin. Rheology modifiers of the present disclosure include compounds which may form covalent bonds with the core resin or diluent resin and compounds which have a particle size of 1-200 nm. Rheology modifiers which may form covalent bonds have at least one terminal functional group selected from the group consisting of acrylates, methacrylates, epoxides, oxetanes, nitriles, alkenes and alkynes.

Abstract: This invention relates to a method for training a neural network, comprising detecting a hole in each training image of a plurality of training images; transforming each training image into a transformed image, to suppress non-crack information in the training image; and training a neural network using the transformed images, to detect cracks in images (i.e. in objects in images).

Abstract: There is provided a method of communication between functional blocks in a system-on-chip.

Abstract: There is provided a chromatography system comprising a first valve in fluid connection to a first chromatography column and/or a second valve; the second valve in fluid connection to a second chromatography column and the first valve; wherein the first valve and the second valve are operable to provide: a mode that selectively allows a fluid to flow from the first chromatography column to the second chromatography column; and one or more modes that selectively allows the fluid to bypass the first chromatography column and/or the second chromatography column. Also disclosed is a method of capturing and/or purifying a target from a sample thereof. In one embodiment, an acidic protein, alpha-1 anti-trypsin (A1AT), is purified by a tandem column configuration using anion exchange chromatography, whereby a first chromatography column is added in between the sample pump and an injection valve, or replaced the sample loop of AKTA system.

Abstract: Herein provided is a multilayered structure including one or more nanocrystalline layers each comprising a transition metal dichalcogenide, one or more substantially amorphous electrically insulating layers each comprising a transition metal oxide, wherein the transition metal oxide comprises a transition metal which is identical to the transition metal of the transition metal dichalcogenide, wherein the one or more nanocrystalline layers and the one or more substantially amorphous electrically insulating layers are formed in an alternating manner, and wherein each of the one or more nanocrystalline layers is formed adjacent to the substantially amorphous insulating layer. A resistive memory device comprising the multilayered structure and a process of fabricating the multilayered structure are also disclosed herein.

Abstract: Techniques regarding post polymerization modifications to polycarbonate polymers via a flow reactor are provided. For example, one or more embodiments described herein can comprise a cyclic carbonate monomer that can be employed to facilitate polymerization of one or more polycarbonate platforms susceptible to post polymerization modification. For instance, one or more embodiments can regard a cyclic carbonate molecular backbone covalently bonded to an aryl halide functional group via in accordance with a chemical structure selected from the group consisting of: In the chemical structures, “R1” can be selected from the group consisting of a hydrogen atom and a functional group comprising a first alkyl group; “L” can represent a linkage group, comprising: a second alkyl group and an end group having at least one member selected from the group consisting of an oxygen atom and a nitrogen atom; and “A” can represent the aryl halide functional group.

Abstract: The present disclosure relates to derivatives of bicyclic compounds and their uses in therapy. In particular, the present disclosure relates to derivatives of bicyclic compounds for use in modulating kinase enzymatic activity and accordingly modulating kinase-dependent diseases and conditions such as cancer and in specific embodiments, hepatocellular carcinoma (HCC). The present disclosure also relates to methods of synthesizing these compounds.

Abstract: The present invention relates to an antigen-binding protein, or an antigen-binding fragment thereof which binding to CEACAM6, comprising (i) a heavy chain variable domain comprising a VHCDR1 having the amino acid sequence GNTFTSYVMH; a VHCDR2 having the amino acid sequence YINPYNDGTKYNEKFKG; and a VHCDR3 having the amino acid sequence STARATPYFYAMDY and (ii) a light chain variable domain comprising a VLCDR1 having the amino acid sequence KSSQSLLWSVNQNSYLS, a VLCDR2 having the amino acid sequence GASIRES, and a VLCDR3 having the amino acid sequence QHNHGSFLPYT. The present invention also relates to compositions comprising the antigen-binding protein, or antigen-binding fragment thereof, methods of use of the antigen-binding protein, or antigen-binding fragment thereof for cancer treatment, prevention or detection and a kit comprising the antigen-binding protein, or antigen-binding fragment thereof.

Abstract: A method of three-dimensional printing an object having a varying degree of transmissivity to light along an axis of the object, the method comprising the steps of (a) providing a liquefied polymer resin having a plurality of particles therein, the particles being distributed in the liquefied polymer resin based on the density of the particles; and (b) polymerizing the liquefied polymer resin under conditions to form the object layer-by-layer. There is also provided a formulation for three-dimensional printing and a three-dimensional printed object.

Abstract: The crosslinked peptidomimetic macrocycles disclosed herein comprise an alkene or alkyne staple and a poly-amino acid C-terminal tail. These crosslinked peptidomimetic macrocycles have improved binding to MDM2 and MDMX (aka MDM4), are protease resistant, cell permeable without inducing membrane disruption, and intracellularly activate p53 by binding MDM2 and MDMX thereby antagonizing MDM2 and MDMX binding to p53. These peptidomimetic macrocycles may be useful in anticancer therapies, particularly in combination with chemotherapy or radiation therapy.

Abstract: The present disclosure provides a multiplexed amplification reaction kit for identifying a subject suffering from a malignancy sensitive to treatment with an inhibitor of the Wnt signaling pathway, comprising a primer pair capable of amplifying a PTPRK(e13)-RSPO3(e2) R-Spondin gene-fusion. Also disclosed is a method of identifying sensitivity to an inhibitor of Wnt signaling in a subject suffering from a malignancy, comprising detecting the PTPRK(e13)-RSPO3(e2) R-Spondin gene-fusion with a primer pair.

Abstract: Embodiments of the invention provide for a multimodal microscopy system. The multimodal microscopy system may include an illumination module configured to provide a light beam to a sample under test via a delivery path; and an optical arrangement configured to receive the light beam from the sample through a detection path to generate a microscopy image of the sample. The optical arrangement may be operable to switch among a plurality of imaging modalities using the detection path shared by the plurality of imaging modalities. The plurality of imaging modalities may include brightfield microscopy, fluorescent microscopy, and endoscopic microscopy. The multimodal microscopy system may be a multimodal hyperspectral microscopy system.