Patents Assigned to Agency for Science, Technology & Research (A*Star)
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Patent number: 9321630Abstract: A method and apparatus for detecting underwater sounds is disclosed. An embodiment of the apparatus includes a substrate with a vacuum-sealed cavity. A support structure and an acoustic pressure sensor are situated on the substrate. The support structure of the apparatus may include a first oxide layer situated on the substrate, a silicon layer situated on the first oxide layer, and a second oxide layer situated on the silicon layer. The acoustic pressure sensor of the apparatus includes a first electrode layer situated on the substrate, a piezoelectric layer situated on the first electrode layer, and a second electrode layer situated on the piezoelectric layer. In one embodiment, the surface area of the second electrode layer is between about 70 to 90 percent of the surface area of the piezoelectric layer. In various embodiments, the support structure is thicker than the piezoelectric layer.Type: GrantFiled: February 20, 2013Date of Patent: April 26, 2016Assignees: PGS Geophysical AS, Agency For Science Technology and Research (A*STAR)Inventors: Jinghui Xu, Julius Ming-Lin Tsai, Winston Sun, Chengliang Sun
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Patent number: 9316654Abstract: We provide an anti-TAZ agent for the treatment, prophylaxis or alleviation of cancer. We further provide a kit for detecting breast cancer in an individual or susceptibility of the individual to breast cancer comprising means for detection of TAZ expression in the individual or a sample taken from him or her as well as a method of detecting a cancer cell, the method comprising detecting modulation of expression, amount or activity of TAZ in the cell.Type: GrantFiled: June 17, 2013Date of Patent: April 19, 2016Assignee: Agency For Science, Technology and Research (A*STAR)Inventors: Wanjin Hong, Siew Wee Chan
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Patent number: 9309314Abstract: We describe an ELABELA polypeptide comprising a sequence CXXXRCXXXHSRVPFP (SEQ ID NO: 1), in which X signifies an amino acid residue, such as a sequence selected from the group consisting of: SEQ ID NO: 2 to SEQ ID NO: 18, preferably CLQRRCMPLHSRVPFP (SEQ ID NO: 2), or a fragment, homolog, variant or derivative thereof, which polypeptide is capable of maintaining self-renewal and/or pluripotency of a stem cell.Type: GrantFiled: September 25, 2014Date of Patent: April 12, 2016Assignee: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (A*STAR)Inventor: Bruno Reversade
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Patent number: 9273292Abstract: We provide a Chinese Hamster Ovary (CHO) cell which is capable of higher protein sialylation compared to a wild type Chinese Hamster Ovary cell, such as in the presence of functional GnT 1, in which the CHO cell is obtainable by selection with Ricinus communis agglutinin I (RCA-I).Type: GrantFiled: March 3, 2015Date of Patent: March 1, 2016Assignee: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (A*STAR)Inventor: Zhiwei Song
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Publication number: 20150293142Abstract: A fully differential microelectromechanical system (MEMS) accelerometer configured to measure Z-axis acceleration is disclosed. This may avoid some of the disadvantages in traditional capacitive sensing architectures—for example, less sensitivity, low noise suppression, and low SNR, due to Brownian noise. In one embodiment, the accelerometer comprises three silicon wafers, fabricated with electrodes forming capacitors in a fully differential capacitive architecture. These electrodes may be isolated on a layer of silicon dioxide. In some embodiments, the accelerometer also includes silicon dioxide layers, piezoelectric structures, getter layers, bonding pads, bonding spacers, and force feedback electrodes, which may apply a force to the proof mass region. Fully differential MEMS accelerometers may be used in geophysical surveys, e.g., for seismic sensing or acoustic positioning.Type: ApplicationFiled: June 3, 2014Publication date: October 15, 2015Applicants: PGS Geophysical AS, Agency for Science Technology and Research (A*STAR)Inventors: Ilker Ender Ocak, Chengliang Sun, Julius Ming-Lin Tsai, Sanchitha Nirodha Fernando
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Publication number: 20150184135Abstract: We provide a Chinese Hamster Ovary (CHO) cell which is capable of higher protein sialylation compared to a wild type Chinese Hamster Ovary cell, such as in the presence of functional GnT 1, in which the CHO cell is obtainable by selection with Ricinus communis agglutinin I (RCA-I).Type: ApplicationFiled: March 3, 2015Publication date: July 2, 2015Applicant: Agency For Science, Technology And Research (A*STAR)Inventor: Zhiwei Song
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Publication number: 20150153365Abstract: We describe an ELABELA polypeptide comprising a sequence CXXXRCXXXHSRVPFP (SEQ ID NO: 1), in which X signifies an amino acid residue, such as a sequence selected from the group consisting of: SEQ ID NO: 2 to SEQ ID NO: 18, preferably CLQRRCMPLHSRVPFP (SEQ ID NO: 2), or a fragment, homologue, variant or derivative thereof, which polypeptide is capable of maintaining self-renewal and/or pluripotency of a stem cell.Type: ApplicationFiled: September 25, 2014Publication date: June 4, 2015Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (A*STAR)Inventor: Bruno REVERSADE
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Publication number: 20150125490Abstract: Described herein are stein cells and related factors for treating degenerative and inflammatory disorders of lung tissue.Type: ApplicationFiled: October 29, 2012Publication date: May 7, 2015Applicants: Agency for Science, Technology and Research (A*STAR), Multiclonal TherapeuticsInventors: Wa Xian, Frank Mckeon, Matthew Vincent
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Patent number: 9012176Abstract: We provide a Chinese Hamster Ovary (CHO) cell which is capable of higher protein sialylation compared to a wild type Chinese Hamster Ovary cell, such as in the presence of functional GnT 1, in which the CHO cell is obtainable by selection with Ricinus communis agglutinin I (RCA-I).Type: GrantFiled: September 18, 2009Date of Patent: April 21, 2015Assignee: Agency for Science, Technology and Research (A*Star)Inventor: Zhiwei Song
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Publication number: 20140260618Abstract: A microelectromechanical system (MEMS) accelerometer having separate sense and force-feedback electrodes is disclosed. The use of separate electrodes may in some embodiments increase the dynamic range of such devices. Other possible advantages include, for example, better sensitivity, better noise suppression, and better signal-to-noise ratio. In one embodiment, the accelerometer includes three silicon wafers, fabricated with sensing electrodes forming capacitors in a fully differential capacitive architecture, and with separate force feedback electrodes forming capacitors for force feedback. These electrodes may be isolated on a layer of silicon dioxide. In some embodiments, the accelerometer also includes silicon dioxide layers, piezoelectric structures, getter layers, bonding pads, bonding spacers, and force feedback electrodes, which may apply a restoring force to the proof mass region. MEMS accelerometers with force-feedback electrodes may be used in geophysical surveys, e.g.Type: ApplicationFiled: February 26, 2014Publication date: September 18, 2014Applicants: Agency for Science Technology and Research (A*STAR), PGS Geophysical ASInventors: Ilker Ender Ocak, Chengliang Sun, Julius Ming-Lin Tsai, Sanchitha Nirodha Fernando
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Publication number: 20140260617Abstract: A fully differential microelectromechanical system (MEMS) accelerometer configured to measure Z-axis acceleration is disclosed. This may avoid some of the disadvantages in traditional capacitive sensing architectures—for example, less sensitivity, low noise suppression, and low SNR, due to Brownian noise. In one embodiment, the accelerometer comprises three silicon wafers, fabricated with electrodes forming capacitors in a fully differential capacitive architecture. These electrodes may be isolated on a layer of silicon dioxide. In some embodiments, the accelerometer also includes silicon dioxide layers, piezoelectric structures, getter layers, bonding pads, bonding spacers, and force feedback electrodes, which may apply a force to the proof mass region. Fully differential MEMS accelerometers may be used in geophysical surveys, e.g., for seismic sensing or acoustic positioning.Type: ApplicationFiled: February 26, 2014Publication date: September 18, 2014Applicants: Agency for Science Technology and Research (A*STAR), PGS Geophysical ASInventors: Ilker Ender Ocak, Chengliang Sun, Julius Ming-Lin Tsai, Sanchitha Nirodha Fernando
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Publication number: 20140255430Abstract: The invention described herein relates to the treatment, detection, and diagnosis of various cancers, including esophageal or gastric adenocarcinoma and related metaplasias. The invention also includes a clonal population of Barrett's esophagus progenitor cells and methods of using them for the treatment, detection, and diagnosis of Barrett's esophagus.Type: ApplicationFiled: December 20, 2013Publication date: September 11, 2014Applicants: NATIONAL UNIVERSITY OF SINGAPORE, Agency for Science, Technology and Research (A*Star), Harvard University, Brigham & Women's Hospital, Multiclonal Therapeutics, Inc.Inventors: Wa XIAN, Frank MCKEON, Matthew VINCENT, Christopher CRUM, Khek Yu HO
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Publication number: 20140242092Abstract: We provide VHZ for use in a method of treatment, prophylaxis or alleviation of a cancer, such as breast cancer, in an individual. We provide an anti-VHZ agent for the treatment, prophylaxis or alleviation of cancer. We further provide a kit for detecting breast cancer in an individual or susceptibility of the individual to breast cancer comprising means for detection of VHZ expression in the individual or a sample taken from him or her as well as a method of detecting a cancer cell, the method comprising detecting modulation of expression, amount or activity of VHZ in the cell.Type: ApplicationFiled: May 13, 2014Publication date: August 28, 2014Applicant: Agency For Science, Technology And Research (A*STAR)Inventor: Qi Zeng
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Publication number: 20140230557Abstract: A method and apparatus for detecting underwater sounds is disclosed. An embodiment of the apparatus includes a substrate with a vacuum-sealed cavity. A support structure and an acoustic pressure sensor are situated on the substrate. The support structure of the apparatus may include a first oxide layer situated on the substrate, a silicon layer situated on the first oxide layer, and a second oxide layer situated on the silicon layer. The acoustic pressure sensor of the apparatus includes a first electrode layer situated on the substrate, a piezoelectric layer situated on the first electrode layer, and a second electrode layer situated on the piezoelectric layer. In one embodiment, the surface area of the second electrode layer is between about 70 to 90 percent of the surface area of the piezoelectric layer. In various embodiments, the support structure is thicker than the piezoelectric layer.Type: ApplicationFiled: February 20, 2013Publication date: August 21, 2014Applicants: Agency for Science Technology and Research (A"STAR), PGS Geophysical ASInventors: Jinghui Xu, Julius Ming-Lin Ming-Lin Tsai, Winston Sun, Chengliang Sun
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Patent number: 8765388Abstract: We provide VHZ for use in a method of treatment, prophylaxis or alleviation of a cancer, such as breast cancer, in an individual. We provide an anti-VHZ agent for the treatment, prophylaxis or alleviation of cancer. We further provide a kit for detecting breast cancer in an individual or susceptibility of the individual to breast cancer comprising means for detection of VHZ expression in the individual or a sample taken from him or her as well as a method of detecting a cancer cell, the method comprising detecting modulation of expression, amount or activity of VHZ in the cell.Type: GrantFiled: August 8, 2008Date of Patent: July 1, 2014Assignee: Agency for Science, Technology and Research (A*Star)Inventor: Qi Zeng
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Patent number: 8715674Abstract: We provide an antibody capable of binding to an intracellular PRL-1 or PRL-3 polypeptide, in which the antibody is capable of binding to an epitope bound by antibody 269, antibody 223 or antibody 318. Such anti-PRL antibodies may be capable of binding to intracellular PRL-1 or PRL-3. They may be suitable for use as therapies against cancer or metastasis thereof, or in clinical diagnosis to identify PRL-3 or PRL-1 positive patients.Type: GrantFiled: May 3, 2008Date of Patent: May 6, 2014Assignee: Agency for Science, Technology and Research (A*Star)Inventor: Qi Zeng
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Publication number: 20130338028Abstract: We provide an anti-TAZ agent for the treatment, prophylaxis or alleviation of cancer. We further provide a kit for detecting breast cancer in an individual or susceptibility of the individual to breast cancer comprising means for detection of TAZ expression in the individual or a sample taken from him or her as well as a method of detecting a cancer cell, the method comprising detecting modulation of expression, amount or activity of TAZ in the cell.Type: ApplicationFiled: June 17, 2013Publication date: December 19, 2013Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (A*STAR)Inventors: Wanjin Hong, Siew Wee Chan
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Patent number: 8486903Abstract: We provide an anti-TAZ agent for the treatment, prophylaxis or alleviation of cancer. We further provide a kit for detecting breast cancer in an individual or susceptibility of the individual to breast cancer comprising means for detection of TAZ expression in the individual or a sample taken from him or her as well as a method of detecting a cancer cell, the method comprising detecting modulation of expression, amount or activity of TAZ in the cell.Type: GrantFiled: October 6, 2008Date of Patent: July 16, 2013Assignee: Agency for Science, Technology and Research (A*STAR)Inventors: Wanjin Hong, Siew Wee Chan
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Publication number: 20120052505Abstract: The present invention relates to methods of detecting, in a sample, embryonic stem cells, induced pluripotent stem cells, and/or cells undergoing reprogramming to produce induced pluripotent stem cells. These methods include providing a sample potentially containing such cells and providing a rosamine derivative compound of the formula (I): where the rosamine derivative compound selectively produces fluorescent signals for embryonic stem cells, induced pluripotent stem cells, and/or cells undergoing reprogramming to produce induced pluripotent stem cells. These methods also include the steps of contacting the sample with the rosamine derivative compound and detecting the presence of the embryonic stem cells, induced pluripotent stem cells, and/or cells undergoing reprogramming to produce induced pluripotent stem cells based on fluorescent signals emitted by the sample following said contacting.Type: ApplicationFiled: August 22, 2011Publication date: March 1, 2012Applicants: NEW YORK UNIVERSITY, Agency for Science, Technology and Research (A*STAR), NATIONAL UNIVERSITY OF SINGAPOREInventors: Young-Tae CHANG, Hyung Ho HA, Nam Young KANG, Seong Wook YUN, Sung Jin PARK, Young-Hoon AHN
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Patent number: 7998701Abstract: We describe an Fve polypeptide being a fragment, homologue, variant or derivative of Fve protein, which comprises at least one biological activity of Fve protein. Uses of such a polypeptide, etc, and nucleic acids encoding these, in the treatment and prevention of allergy and cancer are also disclosed.Type: GrantFiled: April 16, 2004Date of Patent: August 16, 2011Assignees: National University of Singapore, Agency for Science, Technology and Research (A*STAR)Inventors: Kaw Yan Chua, See Voon Seow, Prasanna Ratnakar Kolatkar