Abstract: According to various embodiments, an inverter-based resistor may be provided. The inverter-based resistor may include at least one digital inverter, wherein each of the at least one digital inverter is configured to receive an input and provide an output, each of the at least one digital inverter further includes a positive voltage rail and a negative voltage rail, wherein the digital inverter input is connected to the inverter output and the positive voltage rail is connected to the negative voltage rail, and wherein a current flowing through the inverter-based resistor varies in direction and magnitude in response to a digital input provided to the positive voltage rail and the negative voltage rail.

Abstract: The present invention relates to antimicrobial imidazolium compounds having the structure of Formula (I) wherein R is an optionally substituted aliphatic group that is linear, cyclic, saturated, unsaturated or any combination thereof; n is an integer of at least 1; and X is an anionic counterion. The present invention also relates to pharmaceutical composition comprising the compound, a gel comprising the compound, uses of the compound as an antibiotic and methods for the preparation of the gels.

Abstract: A computer system for acquiring a control command. The system includes one or more processors in communication with non-transitory data storage media having instructions stored thereon that, when executed by the one or more processors, configure the one or more processors to perform particular steps. The steps include: receiving, at an electroencephalogram (EEG) receiver, baseline EEG data; and acquiring, using a normalisation module, one or more normalisation factors from the baseline EEG data. The steps further include: receiving, at the EEG receiver, stimulated EEG data sensed by one or more EEG sensors; and correlating the stimulated EEG data across the one or more EEG sensors, using a correlation module, to generate one or more correlation coefficients corresponding to one or more stimulation frequencies, each of the one or more stimulation frequencies corresponding to a respective candidate control command.

Abstract: We describe the use of exosome such as mesenchymal stem cell exosomes in a method of promoting, restoring or enhancing homeostasis in an individual suffering from graft versus host disease (GVHD) or epidermolysis bullosa (EB). The homeostasis may comprise immune homeostasis such as maintenance of an immune response. The method may comprise administering a therapeutically effective amount of exosome to the individual.

Abstract: The present invention provides for functional chimeric gene regulatory units capable of driving strong and sustained heterologous gene expression.

Abstract: A vital signs detecting device and a method for detecting vital signs are provided. The vital signs detecting device comprises a detection unit; a multimode optical fiber configured to be connected to a light source and to the detection unit; a mechanical structure configured for receiving a pressure exerted by a person's body as a result of one or more of a group consisting of a movement of the person's body, a respiratory action of the person's body and a heart beat action of the person's body and to cause microbending of the multimode optical fiber under the exerted pressure and; wherein the multimode optical fiber is disposed between first and second sets of microbending elements of the mechanical structure substantially in a direction of the exerted pressure.

Abstract: A method and devices for controlling a potentiostat control loop circuit to provide an accurate cell voltage for electrochemically sensing a sample, wherein the cell voltage corresponds to a difference between electrode voltages a working electrode and a reference electrode of a three-electrode potentiostat are provided. The devices include a potentiostat control loop circuit having a first amplifier with an output connected to a counter electrode of the three electrode potentiostat and a first input connected to a first potential and a first switched capacitor network including a first capacitance device having a first electrode connected to a second input of the first amplifier. The first switched capacitor network is also operatively connected to the first amplifier for operating in a first mode and a second mode t switchably couple the second input of the first amplifier to the reference electrode of the three-electrode potentiostat.

Abstract: There is provided a sensing device for measuring a level of an analyte. The sensing device includes a sensing element configured to sense the analyte and produce an electrical output which is variable based on the level of the analyte sensed, a measurement circuit including a reference element for providing an electrical property, the measurement circuit being connected to the sensing element and configured to provide a measurement output signal based on the electrical property of the reference element and the electrical output of the sensing element, whereby the measurement output signal indicates the level of the analyte sensed with respect to the electrical property of the reference element. There is also provided a corresponding method of fabricating the sensing device.

Abstract: The present invention relates to certain compounds (e.g., imidazopyrazine, imidazopyridine, imidazopyridazine and imidazpyrimidine compounds) that act as inhibitors of the MAP kinase interacting kinases MNK2a, MNK2b, MNK1a, and MNK1b. The present invention further relates to pharmaceutical compositions comprising these compounds, and to the use of the compounds for the prevention and treatment of diseases (e.g., proliferative diseases (e.g., cancer), inflammatory diseases, autoimmune diseases, metabolic diseases, and neurodegenerative diseases (e.g. autism, autism spectrum disorders, Alzheimer's disease)), as well as methods of treating these diseases.

Abstract: The present invention relates to a microarray device for detecting a target molecule such as miRNA in a sample. The device comprises a carrier substrate such as glass, an anti-fouling polymer layer which is functionalised with N-Hydroxysuccinimide (NHS) or carboxyl-groups and a capture probe. In an embodiment, the capture probe is an oligonucleotide with a stem-loop structure. The invention further defines a method for fabricating the device, a kit for detecting the target nucleic acid molecule comprising the device and a detection probe.

Abstract: Contemplated is a semiconductor device comprising: a substrate; a group (III)-nitride layer; a metal-group (III)-nitride layer deposited between the substrate and group (III)-nitride layer; and a metal-nitride layer deposited between the substrate and the metal-group (III)-nitride layer. Also a method for making a semiconductor device with the above mentioned structure is contemplated. Furthermore, the substrate can be a silicon on insulator (SOI) substrate; the metal-nitride layer can be an aluminium nitride layer; the metal-group (III)-nitride layer can be an aluminium gallium nitride layer; and the group (III)-nitride layer can be a gallium nitride layer.

Abstract: Various aspects of this disclosure provide a method of encrypting data in a network system. The method may include generating within a trusted network of the network system an associated private key based on an attribute associated with an user, a homomorphically encrypted associated private key based on the associated private key via homomorphic encryption, and a homomorphic key pair. The method may also include transmitting the homomorphically encrypted associated private key from the trusted network to a non-trusted network of the network system. The method may further include generating within the trusted network encrypted data based on said data, and a homomorphically and attribute based encrypted control key. The method may further include transmitting the encrypted data, and the homomorphically and attribute based encrypted control key, from the trusted network to the non-trusted network.

Abstract: Disclosed is a device for cell culture, the device includes a first chamber having an area for containing cells, such as isolated cells, for growth; a second chamber for containing culture medium; a semi permeable membrane forming at least part of a divider between the first chamber and the second chamber; wherein the area for containing cells for growth is adjustable via a moveable wall disposed within the first chamber. The device is especially suited for culturing of semi-adherent and non-adherent cells.

Abstract: The invention relates to the use of compounds of general structure (I) in modulation of the Wnt pathway [Formula should be inserted here] wherein R1, R2, R3, R4 and R5 are each, independently, H or an alkyl group; D is selected from the group consisting of H, halogen, alkyl, cycloalkyl, aryl, and dialkylamino, each (other than H and halogen) being optionally substituted; Ar is an aryl or heteroaryl group, optionally substituted; Cy is an aryl, heteroaryl or a saturated ring containing at least one heteroatom, each being optionally substituted; and n is an integer from 1 to 3.

Abstract: The present disclosure provides a multiplexed amplification reaction kit for identifying a subject suffering from a malignancy sensitive to treatment with an inhibitor of the Wnt signaling pathway, comprising a primer pair capable of amplifying a PTPRK(e13)-RSPO3(e2) R-Spondin gene-fusion. Also disclosed is a method of identifying sensitivity to an inhibitor of Wnt signaling in a subject suffering from a malignancy, comprising detecting the PTPRK(e13)-RSPO3(e2) R-Spondin gene-fusion with a primer pair.

Abstract: A coating comprising a metal-organic framework, wherein the metal-organic framework having a zeolitic structure comprising at least one multivalent metal species and at least one organic ligand (such as zeolitic imidazolate framework (ZIF)). Said coating has a topography comprising an array of projections, and each projection having at least one tapered distal end. There is also provided a method of coating substrates with the disclosed coating and use of said coating as a disinfectant, an antiseptic, or an antibiotic. Such use is possible because the tapered distal end of the disclosed zeolitic structure exerting higher pressure on any microbial cell that comes into contact with the disclosed coating, thereby piercing through the cell membrane more easily, causing cell deformation and lysis.

Abstract: Anti-PD-L1 antibodies are disclosed. Also disclosed are pharmaceutical compositions comprising such antibodies, and methods of using such antibodies to restore T-cell function in T-cells exhibiting T-cell exhaustion or T-cell anergy.

Abstract: Various embodiments may provide a device for controlling an electromagnetic wave. The device may include a first electrode layer. The device may also include a second electrode layer. The device may further include a matrix layer between the first electrode layer and the second electrode layer. The matrix layer may include a liquid crystal layer. The matrix layer may also include at least one resonator element in contact with the liquid crystal layer. The liquid crystal layer may be configured to switch from, at least, a first state to a second state in response to a voltage applied between the first electrode layer and the second electrode layer, thereby changing an optical property of the matrix layer to control the electromagnetic wave received by the matrix layer.

Abstract: According to embodiments of the present invention, a sensor patch for detecting extravasation is provided. The sensor patch includes an elastic film, and at least one sensing electrode disposed on the elastic film, wherein an electrical resistance of the at least one sensing electrode is changeable in response to a force acting on the at least one sensing electrode. According to further embodiments of the present invention, a sensing device is also provided.

Abstract: Disclosed are bladder cancer protein biomarkers, methods of determining whether a patient suffers from or shows recurrence of bladder cancer or early stage bladder cancer, or late stage bladder cancer using the bladder cancer protein biomarkers, a detection system, and kits thereof. Said bladder cancer biomarkers comprise at least one of Coronin-IA, Apolipoprotein A-IV, Semenogelin-2, Gamma-synuclein and DJ-1, and variants thereof.