Abstract: Various embodiments may provide a method of forming an electrical connection structure. The method may include forming a cavity on a front surface of a substrate, the substrate including an electrically conductive pad, by etching through the electrically conductive pad. The method may also include forming one or more dielectric liner layers covering an inner surface of the cavity. The method may further include forming a via hole extending from the cavity by etching through the one or more dielectric liner layers, forming one or more further dielectric liner layers covering an inner surface of the via hole. The method may additionally include depositing a suitable electrically conductive material into the cavity and the via hole to form a conductive via having a first portion in the cavity and a second portion in the via hole, a diameter of the first portion different from a diameter of the second portion.

Abstract: METHOD Herein is described a Cnx/ERp57 inhibitor for use in the treatment or prevention of cancer.

Abstract: The present invention generally relates to specific immune-modulatory RNA species that have a small hairpin structure (shRNA), and that can bind to retinoic acid inducible gene I receptor (RIG-I). In particular, said RNA species comprise a nucleotide insertion to create a kink in the stem region. Also encompassed are compositions comprising such shRNA, for use as antiviral or anticancer medication, or as adjuvants in vaccine.

Abstract: Described herein are peptides that may self-assemble into hydrogels. The peptide comprises an amino acid sequence of alternating hydrophobic amino acids (X) and hydrophilic amino acids (Y), wherein each hydrophobic amino acid is independently selected from isoleucine (I), valine (V) and leucine (L), each hydrophilic amino acid is independently selected from arginine (R), lysine (K), glutamic acid (E), and aspartic acid (D), at least one hydrophilic amino acid is selected from arginine and lysine, at least one hydrophilic amino acid is selected from glutamic acid and aspartic acid, and the amino acid sequence contains at least 8 amino acids. Further described is a composition comprising a hydrogel formed of the peptides in a beta-sheet conformation and water or a dried form of the hydrogel. The hydrogel may be used for growing cells. In another aspect, a hybrid hydrogel prepared from IIK12 (IRIKIEIEIRIK) and IK8L (IRIKIRIK) may be used to treat a bacterial and/or fungal infection.

Abstract: According to the present disclosure, a method for detecting an analyte using surface enhanced Raman spectroscopy (SERS) is provided. The method comprises (a) contacting one or more analyte-binding molecules with the analyte under conditions that allow binding of the analyte to the one or more analyte-binding molecules to form a first mixture, wherein the analyte is preferably haptogloblin and the analyte-binding molecule may comprise haemoglobin or is a haptogloblin antibody, (b) contacting a liquid reagent comprising a peroxidase substrate and a peroxide source with the first mixture to form a second mixture, while maintaining pH of the second mixture at 10 or less, (c) quenching the second mixture to form a third mixture, (d) optionally contacting the third mixture with a SERS-active substrate, and (e) detecting a surface enhanced Raman signal from the third mixture and/or a surface of the SERS-active substrate.

Abstract: Various embodiments may relate a chemical sensor. The chemical sensor may include a substrate including a first sealed (or isolated) cavity and a second sealed (or isolated) cavity separate from the first sealed (or isolated) cavity. The chemical sensor may also include an emitter in the first sealed (or isolated) cavity, the emitter configured to emit infrared light. The chemical sensor may further include a detector in the second sealed (or isolated) cavity. The chemical sensor may also include a waveguide configured to carry the infrared light from the emitter to the detector. The waveguide may include a sensing portion configured such that a property of the infrared light carried through the sensing portion changes in response to a chemical entity in contact with the sensing portion. The detector may be configured to detect the change in the property (of the infrared light).

Abstract: The present invention mainly relates to a polymer for delivery of biologically active materials, a complex and a method of synthesis thereof. The polymer comprises a poly(ethylene imine) and at least one monomer, each monomer comprising a modified sugar moiety, preferably galactose, comprising a sulphur atom or a nitrogen atom and a chemical moiety comprising a terminal epoxide for linking the polyethylene imine to the monomer, wherein the sulphur atom or the nitrogen atom links the modified sugar moiety to the chemical moiety. The biologically active material is preferably a gene, siRNA, mRNA or plasmid DNA. Further disclosed is the medical use of said complex in treating a disease caused by a genetic disorder, for example cancer.

Abstract: Various embodiments may provide a device for controlling an electromagnetic wave according to various embodiments. The device may include a medium. The device may further include an array of elements in contact with the medium and may be configured to receive the electromagnetic wave. Each element of the array of elements may include a phase change material configured to switch from, at least, a first state to a second state in response to an external input, thereby changing an optical property of the respective element to control the electromagnetic wave.

Abstract: This document discloses a comparator that is configured to control dead-time between two or more switching transistors. In particular, it is disclosed that the comparator is configured to generate a suitable delay between the switching “OFF” of a transistor and the switching “ON” of another transistor so that the amount of shoot through current flowing between these two transistors are greatly minimized.

Abstract: There is provided a beam steerable antenna system including: an antenna array including a plurality of first radiating elements; a first phase control section coupled to the plurality of first radiating elements, the first phase control section being configured to control a phase of signals from the plurality of first radiating elements to output first phase controlled signals; a first combiner coupled to the first phase control section, the first combiner being configured to combine the first phase controlled signals to output a first combined signal; a first frequency converter coupled to the first combiner, the first frequency converter being configured to downconvert a frequency of the first combined signal to output a first downconverted signal; and a second phase control section coupled to the first frequency converter, the second phase control section being configured to control a phase of the first downconverted signal to output a second phase controlled signal.

Abstract: The present invention relates to a high-throughput method of screening splicing variants of target genes as drug targets or for characterisation of their biological functions. The disclosure provides a method for the screening of splicing variants, comprising: (a) providing a first antisense oligonucleotide capable of inducing a first splice event on the target gene to express a first splicing variant, and a second antisense oligonucleotide capable of inducing a second splice event on the target gene to express a second splicing variant; (b) hybridising the first and second antisense oligonucleotides to a pre-mRNA of the target gene; and (c) characterising the effect of the splice event.

Abstract: Articles having a thermal imprinted adhesive on a substrate of a plurality of certain conicals have improved bonding strength.

Abstract: The present invention relates to compounds of formula (I), combinations and uses thereof for disease therapy, or a pharmaceutically acceptable salt, solvate or polymorph thereof, including all tautomers and stereoisomers thereof wherein.

Abstract: Peptidomimetic macrocycles that comprise all-D configuration ?-amino acids and bind mouse double minute 2 (MDM2 aka E3 ubiquitin-protein ligase) and MDMX (aka MDM4) are described. These all-D configuration ?-amino acid peptidomimetic macrocycles are protease resistant, cell permeable without inducing membrane disruption, and intracellularly activate p53 by binding MDM2 and MDMX thereby antagonizing MDM2 and MDMX binding to p53. These peptidomimetic macrocycles may be useful in anticancer therapies, particularly in combination with chemotherapy or radiation therapy.

Abstract: Method for measuring respiratory vibration on a human or animal skin, including emitting an emission light at a first position on the skin and receiving a diffused light from the emission light at a second position on the skin; storing a vibration signal including a light intensity of the diffused light received over time; wherein the vibration signal corresponds to a mechanical vibration of the skin, and extracting a respiratory parameter from the vibration signal. In particular, at least one of the first position and the second position is in proximity to or at a trachea, a neck or a chest. The system for carrying out the method includes an emitter, a receiver, a circuit, and a processing unit. A set of a sensor module and a skin adhesive patch is also provided.

Abstract: The present invention refers to lambda integrases comprising at least one amino acid mutation at positions 43, 319 and 336 of the lambda integrase as set forth in SEQ ID NO: 1. The invention further refers to nucleic acid molecules comprising the nucleotide sequence encoding the mutant lambda integrase and to host cells containing these nucleic acid molecules. The invention also refers to methods of recombining a nucleic acid of interest into a target nucleic acid in the presence of the mutant lambda integrase and sequence specific recombination kits.

Abstract: Systems and methods for continuous printing of a three-dimensional (3D) object are provided. The system includes a resin tank, an optical image source, a support fluid reservoir and a pumping structure. The resin tank is where the 3D object is printed and includes a print bed to form a base of the 3D object. The optical image source modulates light in accordance with a 3D image to vary a degree and pattern of crosslinking in a photocrosslinkable resin in the resin tank. The support fluid reservoir is in fluid communication with the resin tank and includes a support fluid which is immiscible with the photocrosslinkable resin. And the pumping structure is configured to transfer the support fluid from the support fluid reservoir to the resin tank such that the support fluid rises in the resin tank at a same rate as vertical height of a top of the 3D object as the 3D object is printed on the print bed.

Abstract: Antigen binding molecules capable of binding to CD122 and/or common ? chain (CD132) are disclosed herein. Also disclosed are compositions comprising such antigen binding molecules, and uses and methods using the same.

Abstract: A system for detecting eye blink activity, the system including one or more processors in communication with non-transitory data storage media having instructions stored thereon that, when executed by the one or more processors configure the one or more processors to perform the steps of receiving, with a receiving module, a signal associated with eye blink activity; filtering, at a processing module, the signal to reduce noise from the signal; calculating, at the processing module, a variance of the filtered signal for estimating background noise; removing, at the processing module, background noise associated with the variance; and detecting, at the processing module, eye blink activity by performing duration detection.

Abstract: Systems and methods for laser stimulated lock-in thermography (LLT) crack detection are provided. The system includes a spatial light modulator and a controller. The spatial light modulator reflects a laser beam to focus the laser beam onto a sample for detection of a crack, hole or scratch. The controller is coupled to the spatial light modulator and controls operation of the spatial light modulator to switch focus of the laser beam onto the sample between a plurality of LLT focus configurations for detection of the crack, hole or scratch on the sample. The method includes using a first one of the plurality of LLT configurations for coarse scanning of the sample to detect a crack, hole or scratch on the sample and, when a crack, hole or scratch is detected on the sample, switching to a second one of the plurality of LLT configurations for fine scanning of the crack, hole or scratch on the sample to determine one or more parameters of the crack, hole or scratch on the sample.