Abstract: There is provided a process for producing an aminopropyne or an enaminone comprising the step of reacting a metal acetylide, an amine and a carbonyl-containing compound in the presence of a transition metal catalyst. There is also provided a process for producing an aminopropyne comprising the step of reacting a metal acetylide, an amine and a halide-containing compound in the presence of a transition metal catalyst at a reaction temperature of 50° C. to 150° C. There are also provided processes to further synthesize the aminopropyne produced to obtain a butyneamine, another aminopropyne or a triazol.

Abstract: According to one aspect of the invention, there is provided a pin photodetector comprising a dopant diffusion barrier layer disposed within an active light absorbing region of the pin photodetector.

Abstract: In an embodiment, a wafer level package may be provided. The wafer level package may include a device wafer including a MEMS device, a cap wafer disposed over the device wafer, at least one first interconnect disposed between the device wafer and the cap wafer and configured to provide an electrical connection between the device wafer and the cap wafer, and a conformal sealing ring disposed between the device wafer and the cap wafer and configured to surround the at least one first interconnect and the MEMS device so as to provide a conformally sealed environment for the at least one first interconnect and the MEMS device, wherein the conformal sealing ring may be configured to conform to a respective suitable surface of the device wafer and the cap wafer when the device wafer may be bonded to the cap wafer. A method of forming a wafer level package may also be provided.

Abstract: The invention provides a process for making hydroxymethylfurfural comprising exposing a saccharide, e.g. glucose or fructose, to a metal complex of an N-heterocyclic carbene.

Abstract: The present invention provides a colorimetric method for detecting a polynucleotide strand binding molecule using one type of metal particles modified with a single type of interacting molecules. The interacting molecule is capable of specifically binding to nucleic and of protecting the metal particle from aggregation. Furthermore, the metal particles are capable of aggregation upon salt aggregation and/or cleavage of the interacting molecule, and colorimetric change changes upon aggregation.

Abstract: There is provided at least one isolated cell comprising at least one HBV epitope-reactive exogenous T cell receptor and/or fragment thereof, and methods for producing them. In particular, there is provided polynucleotides, constructs and vectors encoding at least one HBV epitope-reactive exogenous T cell receptor for use in the treatment of Hepatitis B Virus (HBV) and Hepatocellular Carcinoma (HCC). The invention further provides kits and methods of detection of HBV and HCC.

Abstract: An electrocardiogram signal processing system is provided which includes: a wavelet transformation unit comprising a plurality of outputs, each output being connected to one of a plurality of scales, wherein the wavelet transformation unit is adapted to transform an input electrocardiogram signal into a set of wavelets, each wavelet being output to one of the scales; a plurality of signal processing blocks, each of the signal processing blocks coupled to a respective output of the wavelet transformation unit and configured to receive and process the wavelet from the respective output, wherein the signal processing blocks provide processing functions which differ from one another.

Abstract: The use of mesenchymal stem cells cultured in the presence of HS-2 for the treatment of bone fracture. Repair of bone fracture using such cells is enhanced compared with the treatment of bone fracture using mesenchymal cells cultured without HS-2. These mesenchymal stem cells may be formulated in a pharmaceutical composition and injected directly into tissues surrounding the fracture or used in a biocompatible implant or prosthesis.

Abstract: A system and system for monitoring water quality. The system comprises a container for receiving a flow of water to be monitored, the container containing a plurality of fish and configured such that a substantially 3-dimensional group behavior of the fish is accommodated; a first imaging device disposed above the container for obtaining top view video data of the fish; and means for identifying individual fish based on foreground object detection.

Abstract: An apparatus for detecting particles in a fluid is provided including a substrate, a plurality of channel through holes extending through the substrate, wherein the channel through holes are configured to carry the fluid, a plurality of circuits monolithically integrated with the substrate, wherein each circuit of the plurality of circuitries is arranged adjacent a respectively assigned channel through hole, each circuit including a detection electrode and an control circuit coupled to the detection electrode and configured to control access to the detection electrode, wherein each detection electrode is positioned relative to the respectively assigned channel through hole such at least one electrical property of the fluid flowing through the channel through hole can be detected.

Abstract: According to embodiments of the present invention, a method for forming an optical modulator is provided. The method includes providing a substrate, implanting dopants of a first conductivity type into the substrate to form a first doped region, implanting dopants of a second conductivity type into the substrate to form a second doped region, wherein a portion of the second doped region is formed over and overlaps with a portion of the first doped region to form a junction between the respective portions of the first doped region and the second doped region, and wherein a remaining portion of the second doped region is located outside of the junction, and forming a ridge waveguide, wherein the ridge waveguide overlaps with at least a part of the junction.

Abstract: According to embodiments of the present invention, a sensor is provided. The sensor includes a substrate, a beam suspended from the substrate, and a plurality of conductive lines arranged on the beam, wherein the beam is adapted to be displaced in response to a current flowing through the plurality of conductive lines, and a magnetic field interacting with the beam, and wherein the sensor is configured to determine a property of the magnetic field based on the displacement of the beam. According to further embodiments of the present invention, a method of controlling a sensor is also provided.

Abstract: We provide an antibody capable of binding to an intracellular PRL-1 or PRL-3 polypeptide, in which the antibody is capable of binding to an epitope bound by antibody 269, antibody 223 or antibody 318. Such anti-PRL antibodies may be capable of binding to intracellular PRL-1 or PRL-3. They may be suitable for use as therapies against cancer or metastasis thereof, or in clinical diagnosis to identify PRL-3 or PRL-1 positive patients.

Abstract: The present invention relates to a method for immobilizing enzymes in a solid porous support, and to enzymes immobilized in solid porous supports. Specifically, the present invention uses a fluid containing the enzyme under high pressure (such as 25 to 50 Mpa) to immobilize the enzyme (such as CALB) on the porous support (such as silica). The resulting porous support contain more immobilized enzyme than would otherwise have been obtained by a process carried out at atmospheric pressures.

Abstract: We disclose a particle comprising a matrix coated thereon and having a positive charge, the particle being of a size to allow aggregation of primate or human stem cells attached thereto. The particle may comprise a substantially elongate, cylindrical or rod shaped particle having a longest dimension of between 50 ?m and 400 ?m, such as about 200 ?m. It may have a cross sectional dimension of between 20 ?m and 30 ?m. The particle may comprise a substantially compact or spherical shaped particle having a size of between about 20 ?m and about 120 ?m, for example about 65 ?m. We also disclose a method of propagating primate or human stem cells, the method comprising: providing first and second primate or human stem cells attached to first and second respective particles, allowing the first primate or human stem cell to contact the second primate or human stem cell to form an aggregate of cells and culturing the aggregate to propagate the primate or human stem cells for at least one passage.

Abstract: An amphiphilic polymer (A) comprising repeat units of the general formulae (I), (II) and (III): or salts thereof, wherein R1 is H or methyl, R2 is an aliphatic moiety with a main chain of 3 to 30 carbon atoms and 0 to 3 heteroatoms selected from the group N, O, S, Se and Si, and R3 is one of (i) an alicyclic moiety with a main chain of 5 to 80 carbon atoms and 0 to 30 heteroatoms (ii) a moiety —Z—R4 wherein R4 is an alicyclic moiety with a main chain of 5 to 80 carbon atoms and 0 to 30 heteroatoms and Z is an aliphatic bridge of 1 to 3 carbon atoms and 0 to 2 heteroatoms, (iii) an aliphatic moiety with a main chain of 3 to 80 carbon atoms and 0 to about 30, and a C?C group or an azido group.

Abstract: The present invention discloses a series of alkylamino BODIPY dyes, methods for preparing a library of alkyl-amino BODIPY dyes via solid-phase synthesis, and the use of the alkyl-amino BODIPY dyes as fluorescent sensors for protein detection, cell imaging and cytometry applications, and staining of certain cell line.

Abstract: Synthetic polymer substrates comprising a hierarchical surface structure of multiple domes and multiple pillars on said domes, wherein said substrate is a synthetic polymer film, said domes have diameters in the range from about 5 ?m to about 400 ?m, heights in the range from about 2.5 ?m and about 500 ?m, and said pillars have diameters in the range from about 20 nm to about 5 ?m and aspect ratios of from about 2 to about 50, and methods of making and using them.

Abstract: A fiber Bragg grating (FBG) sensor structure, a method of fabricating a FBG sensor structure, and a method of employing a FBG sensor structure comprising an optical fiber portion having at least one FBG formed therein. The FBG sensor structure comprises an optical fiber portion having at least one FBG formed therein; and a sleeve structure capable of transferring vibrations and/or strain along a length thereof; wherein the optical fiber portion is coupled to the sleeve structure such that the central wavelength of the FBG, is variable under the transferred vibrations and/or strain.

Abstract: A method is provided for determining whether transmission signals are present in received signals, the method comprising: receiving a first signal via a first radio resource; receiving a second signal via a second radio resource; determining whether a first transmission signal is present in the received first signal based on the received second signal; and determining whether a second transmission signal is present in the received second signal based on the received first signal.