Patents Assigned to Agene Research Institute Co., Ltd.
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Patent number: 7329497Abstract: The RecQ4 helicase gene, belonging to the RecQ helicase gene family, is revealed herein to be the causative gene of Rothmund-Thomson syndrome. The present inventors found out that it is possible to diagnose Rothmund-Thomson syndrome by detecting mutation of this gene. Further, they uncovered that it is possible to treat patients of Rothmund-Thomson syndrome by utilizing normal RecQ4 helicase gene or proteins thereof.Type: GrantFiled: May 2, 2006Date of Patent: February 12, 2008Assignee: Agene Research Institute Co., Ltd.Inventors: Saori Kitao, Akira Shimamoto, Yasuhiro Furuichi
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Publication number: 20060240470Abstract: The RecQ4 helicase gene, belonging to the RecQ helicase gene family, is revealed herein to be the causative gene of Rothmund-Thomson syndrome. The present inventors found out that it is possible to diagnose Rothmund-Thomson syndrome by detecting mutation of this gene. Further, they uncovered that it is possible to treat patients of Rothmund-Thomson syndrome by utilizing normal RecQ4 helicase gene or proteins thereof.Type: ApplicationFiled: June 30, 2006Publication date: October 26, 2006Applicant: Agene Research Institute Co., Ltd.Inventors: Saori Kitao, Akira Shimamoto, Yasuhiro Furuichi
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Publication number: 20060188928Abstract: The RecQ4 helicase gene, belonging to the RecQ helicase gene family, is revealed herein to be the causative gene of Rothmund-Thomson syndrome. The present inventors found out that it is possible to diagnose Rothmund-Thomson syndrome by detecting mutation of this gene. Further, they uncovered that it is possible to treat patients of Rothmund-Thomson syndrome by utilizing normal RecQ4 helicase gene or proteins thereof.Type: ApplicationFiled: May 2, 2006Publication date: August 24, 2006Applicant: Agene Research Institute Co., Ltd.Inventors: Saori Kitao, Akira Shimamoto, Yasuhiro Furuichi
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Patent number: 7081522Abstract: The RecQ4 helicase gene, belonging to the RecQ helicase gene family, is revealed herein to be the causative gene of Rothmund-Thomson syndrome. The present inventors found out that it is possible to diagnose Rothmund-Thomson syndrome by detecting mutation of this gene. Further, they uncovered that it is possible to treat patients of Rothmund-Thomson syndrome by utilizing normal RecQ4 helicase gene or proteins thereof.Type: GrantFiled: January 19, 2000Date of Patent: July 25, 2006Assignee: Agene Research Institute Co., Ltd.Inventors: Saori Kitao, Akira Shimamoto, Yasuhiro Furuichi
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Publication number: 20040259147Abstract: The RecQ4 helicase gene, belonging to the RecQ helicase gene family, is revealed herein to be the causative gene of Rothmund-Thomson syndrome. The present inventors found out that it is possible to diagnose Rothmund-Thomson syndrome by detecting mutation of this gene. Further, they uncovered that it is possible to treat patients of Rothmund-Thomson syndrome by utilizing normal RecQ4 helicase gene or proteins thereof.Type: ApplicationFiled: July 2, 2004Publication date: December 23, 2004Applicant: Agene Research Institute Co., Ltd.Inventors: Saori Kitao, Akira Shimamoto, Yasuhiro Furuichi
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Patent number: 6544736Abstract: cDNA including the 5′-terminal sequence of full-length mRNA with a cap structure is synthesized from a mRNA sample containing the full-length mRNA with the cap structure and non-full-length mRNA without any cap structure in mixture. At the first step, the phosphate group at 5′-terminus of the non-full-length mRNA in the mRNA sample is removed. At the second step, the cap structure at the 5′-terminus of the full-length mRNA in the mRNA sample is removed. At the third step, an oligoribonucleotide is ligated to the phosphate group at 5′-terminus of mRNA generated through the first and second steps. At the fourth step, mRNA with the oligoribonucleotide ligated at the 5′-terminus thereof at the third step is subjected to a reverse transcriptase process using a short-chain oligonucleotide capable of being annealed to an intermediate sequence within the mRNA as primer, to synthesize a first-strand cDNA.Type: GrantFiled: June 16, 2000Date of Patent: April 8, 2003Assignees: Nippon Gene Co., Ltd., Agene Research Institute Co., Ltd.Inventors: Akira Shimamoto, Yasuhiro Furuichi, Yuko Shibata, Hiroko Funaki, Eiji Ohara, Masanori Watahiki
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Patent number: 6472513Abstract: A gene encoding: (a) a protein comprising an amino acid sequence of SEQ ID NO: 2; or (b) a protein having deletion, substitution or addition of at least one amino acid residue in the amino acid sequence of SEQ ID NO: 2, which has a helicase activity.Type: GrantFiled: October 27, 2000Date of Patent: October 29, 2002Assignee: Agene Research Institute Co., Ltd.Inventors: Akira Shimamoto, Saori Kitao, Yasuhiro Furuichi
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Patent number: 6335435Abstract: A gene encoding: (a) a protein comprising an amino acid sequence of SEQ ID NO: 2; or (b) a protein having deletion, substitution or addition of at least one amino acid residue in the amino acid sequence of SEQ ID NO: 2, which has a helicase activity.Type: GrantFiled: January 24, 2000Date of Patent: January 1, 2002Assignee: Agene Research Institute Co., Ltd.Inventors: Akira Shimamoto, Saori Kitao, Yasuhiro Furuichi