Patents Assigned to Agennix AG
  • Oral Lactoferrin in the Treatment of Severe Sepsis
    Publication number: 20130225477
    Abstract: The present invention relates to lactoferrin for use in the treatment of severe sepsis. In particular, the present invention relates to methods of effectively treating sepsis, in particular, severe sepsis, by administering orally a composition of lactoferrin (LF). More particularly, the present invention relates to methods of treating prophylactically or therapeutically sepsis, in particular, severe sepsis, by administering orally a composition of lactoferrin to patients with an APACHE II score ?25, in particular <25.
    Type: Application
    Filed: February 25, 2011
    Publication date: August 29, 2013
    Applicant: AGENNIX AG
    Inventors: Atul Varadhachary, Karel Petrak
  • PYRAZOLOPYRIMIDINONE KINASE INHIBITOR
    Publication number: 20130035349
    Abstract: The present invention provides a novel pyrazolo[3,4-d]pyrimidin-4-one, specifically a derivative of 1-(pyridine-4-yl)-pyrazolo[3,4-d]pyrimidin-4-one. This compound is a kinase inhibitor that shows unexpected anti-proliferative activity against cells, including against tumor cells, and anti-tumor activity in xenograft tumor models. The compound or a suitable salt or prodrug thereof is useful for the treatment of individuals suffering from a cancer or another proliferative disorder or disease.
    Type: Application
    Filed: October 9, 2012
    Publication date: February 7, 2013
    Applicant: AGENNIX AG
    Inventor: AGENNIX AG
  • Pyrazolopyrimidinone kinase inhibitor
    Patent number: 8304418
    Abstract: The present invention provides a novel pyrazolo[3,4-d]pyrimidin-4-one, specifically a derivative of 1-(pyridine-4-yl)-pyrazolo[3,4-d]pyrimidin-4-one. This compound is a kinase inhibitor that shows unexpected anti-proliferative activity against cells, including against tumor cells, and anti-tumor activity in xenograft tumor models. The compound or a suitable salt or prodrug thereof is useful for the treatment of individuals suffering from a cancer or another proliferative disorder or disease.
    Type: Grant
    Filed: May 28, 2008
    Date of Patent: November 6, 2012
    Assignee: Agennix AG
    Inventor: Arthur F. Kluge
  • LACTOFERRIN IN THE TREATMENT OF MALIGNANT NEOPLASMS AND OTHER HYPERPROLIFERATIVE DISEASES
    Publication number: 20120276126
    Abstract: The present invention relates to methods of treating a hyperproliferative disease by administering a composition of lactoferrin alone or in combination with standard anti-cancer therapies.
    Type: Application
    Filed: July 11, 2012
    Publication date: November 1, 2012
    Applicant: AGENNIX AG
    Inventors: Atul Varadhachary, Rick Barsky, Federica Pericle, Karel Petrak, Yenyun Wang
  • Anti-proliferative combination therapy using certain platinum-based chemotherapeutic agents and EGFR inhibitors or pyrimidine analogues
    Patent number: 8048888
    Abstract: The present invention describes a method or uses of prevention and/or treatment of a cancer or a tumor, and in particular to a combination therapy, methods, compositions and pharmaceutical packages comprising an inhibitor of receptors of the EGFR family or a chemotherapeutically active pyrimidine analogue and certain platinum-based chemotherapeutic agents.
    Type: Grant
    Filed: November 13, 2006
    Date of Patent: November 1, 2011
    Assignee: Agennix AG
    Inventors: Katja Wosikowski-Buters, Christoph Schaab, Marino Schuhmacher, Franz Obermayr, Igor Ivanov
  • RAF INHIBITORS
    Publication number: 20110257207
    Abstract: The present invention provides derivatives of pyrido[2,3-d]pyrimidin-7-one. These compounds are inhibitors or kinases such as Raf, including compounds that show anti-proliferative activity, including against tumor cells, and are useful in the treatment of diseases including cancer.
    Type: Application
    Filed: May 12, 2011
    Publication date: October 20, 2011
    Applicants: Agennix USA Inc, Agennix AG
    Inventors: Alexander BACKES, Joachim VOGT, Peter AMON, Igor IVANOV, Stefan HANNUS, Matthias BORGMANN, Kerrin HANSEN, Rebecca CASAUBON, Chase SMITH, Krishna MURTHI, Arthur KLUGE, Andreas SCHOOP, Lars NEUMANN, Jan EICKHOFF