Abstract: Systems and methods for data communication between multiple computing devices, comprising: transmitting data through a selectable communication medium by constructing a frame for data, dividing the frame into TXU packets, dividing each TXU packet into UDP segments; grouping the UDP segments into windows; and sending each window to a second computing device; receiving the data at the second computing device comprising receiving UDP segments, assembling UDP segments to recreate TXU packets, sending an ACK message for the first UDP segment of each non-final window and for the last UDP segment of a TXU packet of a final window to the first computing device, and sending a NAK message, specifying missing segments; the first computing device, upon receiving the ACK message, sending the next window, and upon receiving a NAK message, retransmitting missing UDP segments; and at the second computing device, upon receiving a final TXU packet for a frame, recreating the frame by reassembling the TXU packets.