Patents Assigned to AGIOS PHARMACEUTICALS, INC
  • METHODS OF USING PYRUVATE KINASE ACTIVATORS
    Publication number: 20140155374
    Abstract: Described herein are methods for using compounds that activate pyruvate kinase.
    Type: Application
    Filed: May 3, 2012
    Publication date: June 5, 2014
    Applicant: AGIOS PHARMACEUTICALS, INC
    Inventor: Shin-San M. Su
  • PYRUVATE KINASE ACTIVATORS FOR USE IN THERAPY
    Publication number: 20140155408
    Abstract: Described herein are methods for using compounds that activate pyruvate kinase.
    Type: Application
    Filed: May 3, 2012
    Publication date: June 5, 2014
    Applicant: AGIOS PHARMACEUTICALS, INC
    Inventor: Shin-San Michael Su
  • Pyruvate kinase M2 modulators, therapeutic compositions and related methods of use
    Patent number: 8742119
    Abstract: Compositions comprising compounds that modulate pyruvate kinase M2 (PKM2) are described herein. Also described herein are methods of using the compounds that modulate PKM2 in the treatment of cancer.
    Type: Grant
    Filed: October 6, 2011
    Date of Patent: June 3, 2014
    Assignee: Agios Pharmaceuticals, Inc.
    Inventors: Francesco G. Salituro, Jeffrey O. Saunders
  • METHODS OF USING PYRUVATE KINASE ACTIVATORS
    Publication number: 20140148444
    Abstract: Described herein are compounds that activate pyruvate kinase, for use in a method for increasing lifetime of the red blood cells, for regulating 2,3-diphosphoglycerate levels in blood and for treating sickle cell anemia.
    Type: Application
    Filed: May 3, 2012
    Publication date: May 29, 2014
    Applicant: AGIOS PHARMACEUTICALS, INC
    Inventor: Shin-San M. Su
  • COMPOUNDS AND THEIR METHODS OF USE
    Publication number: 20140142081
    Abstract: Compounds and compositions comprising compounds that inhibit glutaminase are described herein. Also described herein are methods of using the compounds that inhibit glutaminase in the treatment of cancer.
    Type: Application
    Filed: November 21, 2013
    Publication date: May 22, 2014
    Applicant: AGIOS PHARMACEUTICALS, INC
    Inventors: Rene M. Lemieux, Janeta Popovici-Muller, Francesco G. Salituro, Jeffrey O. Saunders, Jeremy Travins, Yongsheng Chen
  • COMPOUNDS AND THEIR METHODS OF USE
    Publication number: 20140142146
    Abstract: Compounds and compositions comprising compounds that inhibit glutaminase are described herein. Also described herein are methods of using the compounds that inhibit glutaminase in the treatment of cancer.
    Type: Application
    Filed: November 21, 2013
    Publication date: May 22, 2014
    Applicant: AGIOS PHARMACEUTICALS, INC
    Inventors: Rene M. Lemieux, Janeta Popovici-Muller, Francesco G. Salituro, Jeffrey O. Saunders, Jeremy Travins, Shunqi Yan
  • NOVEL N-(4-(AZETIDINE-1-CARBONYL) PHENYL) - (HETERO-) ARYLSULFONAMIDE DERIVATIVES AS PYRUVATE KINASE M2 (PMK2) MODULATORS
    Publication number: 20140073625
    Abstract: Compounds of general Formula (I), and compositions comprising compounds of general formula I that modulate pyruvate kinase M2 (PKM2) are described herein. Also described herein are methods of using the compounds that modulate PKM2 in the treatment of cancer.
    Type: Application
    Filed: December 16, 2011
    Publication date: March 13, 2014
    Applicant: AGIOS PHARMACEUTICALS, INC
    Inventors: Francesco G. Salituro, Jeffrey O. Saunders, Shunqi Yan
  • BICYCLIC PKM2 ACTIVATORS
    Publication number: 20140011804
    Abstract: Compounds and compositions comprising compounds including formula (I) that activate pyruvate kinase M2 (PKM2) are described herein. Also described herein are methods of using the compounds that activate PKM2 in the treatment of cancer.
    Type: Application
    Filed: December 21, 2011
    Publication date: January 9, 2014
    Applicant: AGIOS PHARMACEUTICALS, INC
    Inventors: Francesco G. Salituro, Jeffrey O. Saunders
  • PKM2 modulators for use in the treatment of cancer
    Patent number: 8501953
    Abstract: Compounds that modulate pyruvate kinase M2 (PKM2) are described herein. Also described herein are pharmaceutical compositions comprising the compounds, and methods of using the compounds in the treatment of cancer.
    Type: Grant
    Filed: November 4, 2011
    Date of Patent: August 6, 2013
    Assignee: Agios Pharmaceuticals, Inc
    Inventors: Francesco G. Salituro, Jeffrey O. Saunders
  • METHODS OF IDENTIFYING A CANDIDATE COMPOUND
    Publication number: 20130197106
    Abstract: The invention relates to methods identifying compounds for the treatment of cell proliferation-related disorders, e.g., proliferative disorders such as cancer.
    Type: Application
    Filed: March 31, 2011
    Publication date: August 1, 2013
    Applicant: AGIOS PHARMACEUTICALS, INC
    Inventors: Valeria Fantin, Shin-San Michael Su
  • THERAPEUTICALLY ACTIVE COMPOSITIONS AND THEIR METHODS OF USE
    Publication number: 20130190249
    Abstract: Provided are methods of treating a cancer characterized by the presence of a mutant allele of IDH1/2 comprising administering to a subject in need thereof a compound described here.
    Type: Application
    Filed: January 18, 2013
    Publication date: July 25, 2013
    Applicant: AGIOS PHARMACEUTICALS, INC
    Inventor: Agios Pharmaceuticals, Inc.
  • THERAPEUTICALLY ACTIVE COMPOUNDS AND THEIR METHODS OF USE
    Publication number: 20130190287
    Abstract: Provided are compounds useful for treating cancer and methods of treating cancer comprising administering to a subject in need thereof a compound described herein.
    Type: Application
    Filed: January 7, 2013
    Publication date: July 25, 2013
    Applicant: AGIOS PHARMACEUTICALS, INC.
    Inventor: AGIOS PHARMACEUTICALS, INC.
  • THERAPEUTICALLY ACTIVE COMPOSITIONS AND THEIR METHODS OF USE
    Publication number: 20130184222
    Abstract: Provided are methods of treating a cancer characterized by the presence of a mutant allele of IDH1 comprising administering to a subject in need thereof a compound described here.
    Type: Application
    Filed: July 15, 2011
    Publication date: July 18, 2013
    Applicant: AGIOS PHARMACEUTICALS, INC
    Inventors: Janeta Popovici-Muller, Francesco G. Salituro, Jeffrey Saunders, Jeremy Travins, Shunqi Yan