Patents Assigned to Agrivida, Inc.
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Patent number: 11932864Abstract: The transgenic plants expressing one or more antagonist IL-10R peptides and anti-IL-10 single domain antibodies that stimulate or modulate the immune system and improve gastrointestinal physiology of an animal fed the transgenic plants or tissues thereof and the genes encoding the antagonist IL-10R peptides and anti-IL-10 single domain antibodies are described. The animal feed additives and animal feed incorporating the transgenic plants or tissues thereof are also described. Methods of stimulating or modulating an animal's immune system, improving an animal's gastrointestinal physiology, improving animal performance by using the transgenic plants or tissues thereof, and treating animals infected with a gastrointestinal pathogen are provided.Type: GrantFiled: May 19, 2022Date of Patent: March 19, 2024Assignee: AGRIVIDA INC.Inventors: R. Michael Raab, Oleg Bougri, Matthew Parker, Philip A. Lessard
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Patent number: 11805792Abstract: Methods for enhancing phytase thermal stability by fusing binding elements to target phytases are provided. Engineered phytases that include binding elements fused to target phytases to cause cyclization of the engineered phytases and enhance thermal stability of the target phytases are described. Engineered nucleic acids encoding engineered phytases and hosts engineered to express engineered nucleic acids are also provided. Methods for incorporating engineered phytases in animal feed and animal feed including the same are described.Type: GrantFiled: December 14, 2021Date of Patent: November 7, 2023Assignee: AGRIVIDA, INC.Inventors: R. Michael Raab, Gabor Lazar, Binzhang Shen
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Publication number: 20220315939Abstract: Methods and compositions are described for producing a phytase in transgenic maize plants and then incorporating parts of the transgenic maize plants in animal feed. The feed phytase enzyme displays activity across a broad pH range, and tolerance to temperatures that are often encountered during the process of preparing animal feeds. Methods of producing an animal feed that incorporate the transgenic maize plants, parts thereof or plant derived phytases, as well as methods of promoting the release of inorganic phosphate from a phytic acid in an animal, producing an animal meat, or reducing the ratio of intake of an animal feed per weight of the animal meat by feeding an animal with the animal feed incorporating transgenic maize plants are provided.Type: ApplicationFiled: May 20, 2022Publication date: October 6, 2022Applicant: AGRIVIDA, INC.Inventors: R. Michael RAAB, Oleg BOUGRI, Philip A. LESSARD, Christopher BONIN, Michael B. LANAHAN
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Publication number: 20220282269Abstract: The transgenic plants expressing one or more antagonist IL-10R peptides and anti-IL-10 single domain antibodies that stimulate or modulate the immune system and improve gastrointestinal physiology of an animal fed the transgenic plants or tissues thereof and the genes encoding the antagonist IL-10R peptides and anti-IL-10 single domain antibodies are described. The animal feed additives and animal feed incorporating the transgenic plants or tissues thereof are also described. Methods of stimulating or modulating an animal's immune system, improving an animal's gastrointestinal physiology, improving animal performance by using the transgenic plants or tissues thereof, and treating animals infected with a gastrointestinal pathogen are provided.Type: ApplicationFiled: May 19, 2022Publication date: September 8, 2022Applicant: AGRIVIDA, INC.Inventors: R. Michael RAAB, Oleg BOUGRI, Matthew PARKER, Philip A. LESSARD
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Patent number: 11390879Abstract: The transgenic plants expressing one or more antagonist IL-10R peptides and anti-IL-10 single domain antibodies that stimulate or modulate the immune system and improve gastrointestinal physiology of an animal fed the transgenic plants or tissues thereof and the genes encoding the antagonist IL-10R peptides and anti-IL-10 single domain antibodies are described. The animal feed additives and animal feed incorporating the transgenic plants or tissues thereof are also described. Methods of stimulating or modulating an animal's immune system, improving an animal's gastrointestinal physiology, improving animal performance by using the transgenic plants or tissues thereof, and treating animals infected with a gastrointestinal pathogen are provided.Type: GrantFiled: May 29, 2018Date of Patent: July 19, 2022Assignee: AGRIVIDA, INC.Inventors: R. Michael Raab, Oleg Bougri, Matthew Parker, Philip A. Lessard
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Patent number: 11371052Abstract: Methods and compositions are described for producing a phytase in transgenic maize plants and then incorporating parts of the transgenic maize plants in animal feed. The feed phytase enzyme displays activity across a broad pH range, and tolerance to temperatures that are often encountered during the process of preparing animal feeds. Methods of producing an animal feed that incorporate the transgenic maize plants, parts thereof or plant derived phytases, as well as methods of promoting the release of inorganic phosphate from a phytic acid in an animal, producing an animal meat, or reducing the ratio of intake of an animal feed per weight of the animal meat by feeding an animal with the animal feed incorporating transgenic maize plants are provided.Type: GrantFiled: November 3, 2017Date of Patent: June 28, 2022Assignee: AGRIVIDA, INC.Inventors: R. Michael Raab, Oleg Bougri, Philip A. Lessard, Christopher Bonin, Michael B. Lanahan
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Publication number: 20220095647Abstract: Methods for enhancing phytase thermal stability by fusing binding elements to target phytases are provided. Engineered phytases that include binding elements fused to target phytases to cause cyclization of the engineered phytases and enhance thermal stability of the target phytases are described. Engineered nucleic acids encoding engineered phytases and hosts engineered to express engineered nucleic acids are also provided. Methods for incorporating engineered phytases in animal feed and animal feed including the same are described.Type: ApplicationFiled: December 14, 2021Publication date: March 31, 2022Applicant: AGRIVIDA, INC.Inventors: R. Michael RAAB, Gabor LAZAR, Binzhang SHEN
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Patent number: 11241025Abstract: Methods for enhancing phytase thermal stability by fusing binding elements to target phytases are provided. Engineered phytases that include binding elements fused to target phytases to cause cyclization of the engineered phytases and enhance thermal stability of the target phytases are described. Engineered nucleic acids encoding engineered phytases and hosts engineered to express engineered nucleic acids are also provided. Methods for incorporating engineered phytases in animal feed and animal feed including the same are described.Type: GrantFiled: May 6, 2020Date of Patent: February 8, 2022Assignee: AGRIVIDA, INC.Inventors: R. Michael Raab, Gabor Lazar, Binzhang Shen
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Publication number: 20210380997Abstract: Methods and compositions are described for producing a glucanase in transgenic plants and then incorporating parts of the transgenic plants in animal feed. The feed glucanase enzyme displays activity across a broad pH range, and tolerance to temperatures that are often encountered during the process of preparing animal feeds. Producing the enzyme in the transgenic plant enhances the thermal stability of the enzyme.Type: ApplicationFiled: June 23, 2021Publication date: December 9, 2021Applicant: Agrivida, Inc.Inventors: R. Michael Raab, Oleg Bougri, Xuemei Li
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Patent number: 11098319Abstract: Methods and compositions are described for producing a glucanase in transgenic plants and then incorporating parts of the transgenic plants in animal feed. The feed glucanase enzyme displays activity across a broad pH range, and tolerance to temperatures that are often encountered during the process of preparing animal feeds. Producing the enzyme in the transgenic plant enhances the thermal stability of the enzyme.Type: GrantFiled: October 11, 2019Date of Patent: August 24, 2021Assignee: AGRIVIDA, INC.Inventors: R. Michael Raab, Oleg Bougri, Xuemei Li
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Publication number: 20210254115Abstract: Vectors for expression of proteins in plants are described. The proteins may be enzymes and the enzymes can be but are not limited to cell wall degrading enzymes. A number of plants designed to express specific cell wall degrading enzymes are provided. The plants may have industrial and/or agricultural applications. Methods and materials for making the expression vectors and for making the plants are provided. Processes for which the plants could be used in industrial and agricultural applications are also provided.Type: ApplicationFiled: April 26, 2021Publication date: August 19, 2021Applicant: AGRIVIDA, INC.Inventors: R. Michael Raab, Vlad Samoylov, Oleg Bougri, Nathan Ekborg
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Patent number: 11066657Abstract: Methods for producing a trans-splicing intein-modified protease with enhanced solubility and regulating its activity are described. Intein-modified proteases having enhanced solubility and polynucleotides encoding the same are provided. Methods of storing trans-splicing proteases are also described.Type: GrantFiled: June 11, 2020Date of Patent: July 20, 2021Assignee: AGRIVIDA, INCInventors: R. Michael Raab, Binzhang Shen, Gabor Lazar
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Patent number: 10988788Abstract: Vectors for expression of proteins in plants are described. The proteins may be enzymes and the enzymes can be but are not limited to cell wall degrading enzymes. A number of plants designed to express specific cell wall degrading enzymes are provided. The plants may have industrial and/or agricultural applications. Methods and materials for making the expression vectors and for making the plants are provided. Processes for which the plants could be used in industrial and agricultural applications are also provided.Type: GrantFiled: February 17, 2016Date of Patent: April 27, 2021Assignee: AGRIVIDA, INC.Inventors: R. Michael Raab, Vlad Samoylov, Oleg Bougri, Nathan Ekborg
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Patent number: 10851362Abstract: Methods for producing intein-modified proteases are provided. Expression cassettes and vectors for using to genetically engineer hosts are described. Hosts genetically engineered to express one or more intein-modified proteases using expression cassettes and vectors of the invention are also provided. Methods to produce a protease and regulate its activity are described.Type: GrantFiled: July 5, 2018Date of Patent: December 1, 2020Assignee: AGRIVIDA, INC.Inventors: R. Michael Raab, Binzhang Shen, Gabor Lazar, Humberto De La Vega
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Publication number: 20200308564Abstract: Methods for producing a trans-splicing intein-modified protease with enhanced solubility and regulating its activity are described. Intein-modified proteases having enhanced solubility and polynucleotides encoding the same are provided. Methods of storing trans-splicing proteases are also described.Type: ApplicationFiled: June 11, 2020Publication date: October 1, 2020Applicant: AGRIVIDA, INC.Inventors: R. Michael RAAB, Binzhang SHEN, Gabor LAZAR
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Publication number: 20200299709Abstract: Methods and compositions are described for producing a phytase in transgenic maize plants and then incorporating parts of the transgenic maize plants in animal feed. The feed phytase enzyme displays activity across a broad pH range, and tolerance to temperatures that are often encountered during the process of preparing animal feeds. Methods of producing an animal feed that incorporate the transgenic maize plants, parts thereof or plant derived phytases, as well as methods of promoting the release of inorganic phosphate from a phytic acid in an animal, producing an animal meat, or reducing the ratio of intake of an animal feed per weight of the animal meat by feeding an animal with the animal feed incorporating transgenic maize plants are provided.Type: ApplicationFiled: November 3, 2017Publication date: September 24, 2020Applicant: AGRIVIDA, INC.Inventors: R. Michael RAAB, Oleg BOUGRI, Philip A. LESSARD, Christopher BONIN, Michael B. LANAHAN
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Publication number: 20200275679Abstract: Methods for enhancing phytase thermal stability by fusing binding elements to target phytases are provided. Engineered phytases that include binding elements fused to target phytases to cause cyclization of the engineered phytases and enhance thermal stability of the target phytases are described. Engineered nucleic acids encoding engineered phytases and hosts engineered to express engineered nucleic acids are also provided. Methods for incorporating engineered phytases in animal feed and animal feed including the same are described.Type: ApplicationFiled: May 6, 2020Publication date: September 3, 2020Applicant: AGRIVIDA, INC.Inventors: R. Michael RAAB, Gabor LAZAR, Binzhang SHEN
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Patent number: 10731143Abstract: Methods for producing a trans-splicing intein-modified protease with enhanced solubility and regulating its activity are described. Intein-modified proteases having enhanced solubility and polynucleotides encoding the same are provided. Methods of storing trans-splicing proteases are also described.Type: GrantFiled: October 28, 2015Date of Patent: August 4, 2020Assignee: AGRIVIDA, INC.Inventors: R. Michael Raab, Binzhang Shen, Gabor Lazar
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Patent number: 10687542Abstract: Methods for enhancing phytase thermal stability by fusing binding elements to target phytases are provided. Engineered phytases that include binding elements fused to target phytases to cause cyclization of the engineered phytases and enhance thermal stability of the target phytases are described. Engineered nucleic acids encoding engineered phytases and hosts engineered to express engineered nucleic acids are also provided. Methods for incorporating engineered phytases in animal feed and animal feed including the same are described.Type: GrantFiled: September 16, 2016Date of Patent: June 23, 2020Assignee: AGRIVIDA, INC.Inventors: R. Michael Raab, Gabor Lazar, Binzhang Shen
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Publication number: 20200071716Abstract: The transgenic plants expressing one or more antagonist IL-10R peptides and anti-IL-10 single domain antibodies that stimulate or modulate the immune system and improve gastrointestinal physiology of an animal fed the transgenic plants or tissues thereof and the genes encoding the antagonist IL-10R peptides and anti-IL-10 single domain antibodies are described. The animal feed additives and animal feed incorporating the transgenic plants or tissues thereof are also described. Methods of stimulating or modulating an animal's immune system, improving an animal's gastrointestinal physiology, improving animal performance by using the transgenic plants or tissues thereof, and treating animals infected with a gastrointestinal pathogen are provided.Type: ApplicationFiled: May 29, 2018Publication date: March 5, 2020Applicant: AGRIVIDA, INC.Inventors: R. Michael RAAB, Oleg BOUGRI, Matthew PARKER, Philip A. LESSARD