Patents Assigned to Agrivida, Inc.
  • Patent number: 11932864
    Abstract: The transgenic plants expressing one or more antagonist IL-10R peptides and anti-IL-10 single domain antibodies that stimulate or modulate the immune system and improve gastrointestinal physiology of an animal fed the transgenic plants or tissues thereof and the genes encoding the antagonist IL-10R peptides and anti-IL-10 single domain antibodies are described. The animal feed additives and animal feed incorporating the transgenic plants or tissues thereof are also described. Methods of stimulating or modulating an animal's immune system, improving an animal's gastrointestinal physiology, improving animal performance by using the transgenic plants or tissues thereof, and treating animals infected with a gastrointestinal pathogen are provided.
    Type: Grant
    Filed: May 19, 2022
    Date of Patent: March 19, 2024
    Assignee: AGRIVIDA INC.
    Inventors: R. Michael Raab, Oleg Bougri, Matthew Parker, Philip A. Lessard
  • Patent number: 11805792
    Abstract: Methods for enhancing phytase thermal stability by fusing binding elements to target phytases are provided. Engineered phytases that include binding elements fused to target phytases to cause cyclization of the engineered phytases and enhance thermal stability of the target phytases are described. Engineered nucleic acids encoding engineered phytases and hosts engineered to express engineered nucleic acids are also provided. Methods for incorporating engineered phytases in animal feed and animal feed including the same are described.
    Type: Grant
    Filed: December 14, 2021
    Date of Patent: November 7, 2023
    Assignee: AGRIVIDA, INC.
    Inventors: R. Michael Raab, Gabor Lazar, Binzhang Shen
  • Publication number: 20220315939
    Abstract: Methods and compositions are described for producing a phytase in transgenic maize plants and then incorporating parts of the transgenic maize plants in animal feed. The feed phytase enzyme displays activity across a broad pH range, and tolerance to temperatures that are often encountered during the process of preparing animal feeds. Methods of producing an animal feed that incorporate the transgenic maize plants, parts thereof or plant derived phytases, as well as methods of promoting the release of inorganic phosphate from a phytic acid in an animal, producing an animal meat, or reducing the ratio of intake of an animal feed per weight of the animal meat by feeding an animal with the animal feed incorporating transgenic maize plants are provided.
    Type: Application
    Filed: May 20, 2022
    Publication date: October 6, 2022
    Applicant: AGRIVIDA, INC.
    Inventors: R. Michael RAAB, Oleg BOUGRI, Philip A. LESSARD, Christopher BONIN, Michael B. LANAHAN
  • Publication number: 20220282269
    Abstract: The transgenic plants expressing one or more antagonist IL-10R peptides and anti-IL-10 single domain antibodies that stimulate or modulate the immune system and improve gastrointestinal physiology of an animal fed the transgenic plants or tissues thereof and the genes encoding the antagonist IL-10R peptides and anti-IL-10 single domain antibodies are described. The animal feed additives and animal feed incorporating the transgenic plants or tissues thereof are also described. Methods of stimulating or modulating an animal's immune system, improving an animal's gastrointestinal physiology, improving animal performance by using the transgenic plants or tissues thereof, and treating animals infected with a gastrointestinal pathogen are provided.
    Type: Application
    Filed: May 19, 2022
    Publication date: September 8, 2022
    Applicant: AGRIVIDA, INC.
    Inventors: R. Michael RAAB, Oleg BOUGRI, Matthew PARKER, Philip A. LESSARD
  • Patent number: 11390879
    Abstract: The transgenic plants expressing one or more antagonist IL-10R peptides and anti-IL-10 single domain antibodies that stimulate or modulate the immune system and improve gastrointestinal physiology of an animal fed the transgenic plants or tissues thereof and the genes encoding the antagonist IL-10R peptides and anti-IL-10 single domain antibodies are described. The animal feed additives and animal feed incorporating the transgenic plants or tissues thereof are also described. Methods of stimulating or modulating an animal's immune system, improving an animal's gastrointestinal physiology, improving animal performance by using the transgenic plants or tissues thereof, and treating animals infected with a gastrointestinal pathogen are provided.
    Type: Grant
    Filed: May 29, 2018
    Date of Patent: July 19, 2022
    Assignee: AGRIVIDA, INC.
    Inventors: R. Michael Raab, Oleg Bougri, Matthew Parker, Philip A. Lessard
  • Patent number: 11371052
    Abstract: Methods and compositions are described for producing a phytase in transgenic maize plants and then incorporating parts of the transgenic maize plants in animal feed. The feed phytase enzyme displays activity across a broad pH range, and tolerance to temperatures that are often encountered during the process of preparing animal feeds. Methods of producing an animal feed that incorporate the transgenic maize plants, parts thereof or plant derived phytases, as well as methods of promoting the release of inorganic phosphate from a phytic acid in an animal, producing an animal meat, or reducing the ratio of intake of an animal feed per weight of the animal meat by feeding an animal with the animal feed incorporating transgenic maize plants are provided.
    Type: Grant
    Filed: November 3, 2017
    Date of Patent: June 28, 2022
    Assignee: AGRIVIDA, INC.
    Inventors: R. Michael Raab, Oleg Bougri, Philip A. Lessard, Christopher Bonin, Michael B. Lanahan
  • Publication number: 20220095647
    Abstract: Methods for enhancing phytase thermal stability by fusing binding elements to target phytases are provided. Engineered phytases that include binding elements fused to target phytases to cause cyclization of the engineered phytases and enhance thermal stability of the target phytases are described. Engineered nucleic acids encoding engineered phytases and hosts engineered to express engineered nucleic acids are also provided. Methods for incorporating engineered phytases in animal feed and animal feed including the same are described.
    Type: Application
    Filed: December 14, 2021
    Publication date: March 31, 2022
    Applicant: AGRIVIDA, INC.
    Inventors: R. Michael RAAB, Gabor LAZAR, Binzhang SHEN
  • Patent number: 11241025
    Abstract: Methods for enhancing phytase thermal stability by fusing binding elements to target phytases are provided. Engineered phytases that include binding elements fused to target phytases to cause cyclization of the engineered phytases and enhance thermal stability of the target phytases are described. Engineered nucleic acids encoding engineered phytases and hosts engineered to express engineered nucleic acids are also provided. Methods for incorporating engineered phytases in animal feed and animal feed including the same are described.
    Type: Grant
    Filed: May 6, 2020
    Date of Patent: February 8, 2022
    Assignee: AGRIVIDA, INC.
    Inventors: R. Michael Raab, Gabor Lazar, Binzhang Shen
  • Publication number: 20210380997
    Abstract: Methods and compositions are described for producing a glucanase in transgenic plants and then incorporating parts of the transgenic plants in animal feed. The feed glucanase enzyme displays activity across a broad pH range, and tolerance to temperatures that are often encountered during the process of preparing animal feeds. Producing the enzyme in the transgenic plant enhances the thermal stability of the enzyme.
    Type: Application
    Filed: June 23, 2021
    Publication date: December 9, 2021
    Applicant: Agrivida, Inc.
    Inventors: R. Michael Raab, Oleg Bougri, Xuemei Li
  • Patent number: 11098319
    Abstract: Methods and compositions are described for producing a glucanase in transgenic plants and then incorporating parts of the transgenic plants in animal feed. The feed glucanase enzyme displays activity across a broad pH range, and tolerance to temperatures that are often encountered during the process of preparing animal feeds. Producing the enzyme in the transgenic plant enhances the thermal stability of the enzyme.
    Type: Grant
    Filed: October 11, 2019
    Date of Patent: August 24, 2021
    Assignee: AGRIVIDA, INC.
    Inventors: R. Michael Raab, Oleg Bougri, Xuemei Li
  • Publication number: 20210254115
    Abstract: Vectors for expression of proteins in plants are described. The proteins may be enzymes and the enzymes can be but are not limited to cell wall degrading enzymes. A number of plants designed to express specific cell wall degrading enzymes are provided. The plants may have industrial and/or agricultural applications. Methods and materials for making the expression vectors and for making the plants are provided. Processes for which the plants could be used in industrial and agricultural applications are also provided.
    Type: Application
    Filed: April 26, 2021
    Publication date: August 19, 2021
    Applicant: AGRIVIDA, INC.
    Inventors: R. Michael Raab, Vlad Samoylov, Oleg Bougri, Nathan Ekborg
  • Patent number: 11066657
    Abstract: Methods for producing a trans-splicing intein-modified protease with enhanced solubility and regulating its activity are described. Intein-modified proteases having enhanced solubility and polynucleotides encoding the same are provided. Methods of storing trans-splicing proteases are also described.
    Type: Grant
    Filed: June 11, 2020
    Date of Patent: July 20, 2021
    Assignee: AGRIVIDA, INC
    Inventors: R. Michael Raab, Binzhang Shen, Gabor Lazar
  • Patent number: 10988788
    Abstract: Vectors for expression of proteins in plants are described. The proteins may be enzymes and the enzymes can be but are not limited to cell wall degrading enzymes. A number of plants designed to express specific cell wall degrading enzymes are provided. The plants may have industrial and/or agricultural applications. Methods and materials for making the expression vectors and for making the plants are provided. Processes for which the plants could be used in industrial and agricultural applications are also provided.
    Type: Grant
    Filed: February 17, 2016
    Date of Patent: April 27, 2021
    Assignee: AGRIVIDA, INC.
    Inventors: R. Michael Raab, Vlad Samoylov, Oleg Bougri, Nathan Ekborg
  • Patent number: 10851362
    Abstract: Methods for producing intein-modified proteases are provided. Expression cassettes and vectors for using to genetically engineer hosts are described. Hosts genetically engineered to express one or more intein-modified proteases using expression cassettes and vectors of the invention are also provided. Methods to produce a protease and regulate its activity are described.
    Type: Grant
    Filed: July 5, 2018
    Date of Patent: December 1, 2020
    Assignee: AGRIVIDA, INC.
    Inventors: R. Michael Raab, Binzhang Shen, Gabor Lazar, Humberto De La Vega
  • Publication number: 20200308564
    Abstract: Methods for producing a trans-splicing intein-modified protease with enhanced solubility and regulating its activity are described. Intein-modified proteases having enhanced solubility and polynucleotides encoding the same are provided. Methods of storing trans-splicing proteases are also described.
    Type: Application
    Filed: June 11, 2020
    Publication date: October 1, 2020
    Applicant: AGRIVIDA, INC.
    Inventors: R. Michael RAAB, Binzhang SHEN, Gabor LAZAR
  • Publication number: 20200299709
    Abstract: Methods and compositions are described for producing a phytase in transgenic maize plants and then incorporating parts of the transgenic maize plants in animal feed. The feed phytase enzyme displays activity across a broad pH range, and tolerance to temperatures that are often encountered during the process of preparing animal feeds. Methods of producing an animal feed that incorporate the transgenic maize plants, parts thereof or plant derived phytases, as well as methods of promoting the release of inorganic phosphate from a phytic acid in an animal, producing an animal meat, or reducing the ratio of intake of an animal feed per weight of the animal meat by feeding an animal with the animal feed incorporating transgenic maize plants are provided.
    Type: Application
    Filed: November 3, 2017
    Publication date: September 24, 2020
    Applicant: AGRIVIDA, INC.
    Inventors: R. Michael RAAB, Oleg BOUGRI, Philip A. LESSARD, Christopher BONIN, Michael B. LANAHAN
  • Publication number: 20200275679
    Abstract: Methods for enhancing phytase thermal stability by fusing binding elements to target phytases are provided. Engineered phytases that include binding elements fused to target phytases to cause cyclization of the engineered phytases and enhance thermal stability of the target phytases are described. Engineered nucleic acids encoding engineered phytases and hosts engineered to express engineered nucleic acids are also provided. Methods for incorporating engineered phytases in animal feed and animal feed including the same are described.
    Type: Application
    Filed: May 6, 2020
    Publication date: September 3, 2020
    Applicant: AGRIVIDA, INC.
    Inventors: R. Michael RAAB, Gabor LAZAR, Binzhang SHEN
  • Patent number: 10731143
    Abstract: Methods for producing a trans-splicing intein-modified protease with enhanced solubility and regulating its activity are described. Intein-modified proteases having enhanced solubility and polynucleotides encoding the same are provided. Methods of storing trans-splicing proteases are also described.
    Type: Grant
    Filed: October 28, 2015
    Date of Patent: August 4, 2020
    Assignee: AGRIVIDA, INC.
    Inventors: R. Michael Raab, Binzhang Shen, Gabor Lazar
  • Patent number: 10687542
    Abstract: Methods for enhancing phytase thermal stability by fusing binding elements to target phytases are provided. Engineered phytases that include binding elements fused to target phytases to cause cyclization of the engineered phytases and enhance thermal stability of the target phytases are described. Engineered nucleic acids encoding engineered phytases and hosts engineered to express engineered nucleic acids are also provided. Methods for incorporating engineered phytases in animal feed and animal feed including the same are described.
    Type: Grant
    Filed: September 16, 2016
    Date of Patent: June 23, 2020
    Assignee: AGRIVIDA, INC.
    Inventors: R. Michael Raab, Gabor Lazar, Binzhang Shen
  • Publication number: 20200071716
    Abstract: The transgenic plants expressing one or more antagonist IL-10R peptides and anti-IL-10 single domain antibodies that stimulate or modulate the immune system and improve gastrointestinal physiology of an animal fed the transgenic plants or tissues thereof and the genes encoding the antagonist IL-10R peptides and anti-IL-10 single domain antibodies are described. The animal feed additives and animal feed incorporating the transgenic plants or tissues thereof are also described. Methods of stimulating or modulating an animal's immune system, improving an animal's gastrointestinal physiology, improving animal performance by using the transgenic plants or tissues thereof, and treating animals infected with a gastrointestinal pathogen are provided.
    Type: Application
    Filed: May 29, 2018
    Publication date: March 5, 2020
    Applicant: AGRIVIDA, INC.
    Inventors: R. Michael RAAB, Oleg BOUGRI, Matthew PARKER, Philip A. LESSARD