Abstract: This invention relates to a transgenic vector for transducing cells of a mammal's CNS and transgenically expressing a protein in the mammal's CNS. The transgenic vector comprises a virus-derived vector, a nucleic acid sequence encoding the protein, and an endogenous ATP1A3 promoter sequence. This invention also relates to a composition comprising a recombinant AAV vector comprising a nucleic acid sequence encoding a ATP1A3 protein, in a form compatible with administration into the CNS. The invention also relates to a method for treating a subject having a neurological disorder associated with mutations in the ATP1A3 gene and a method for delivering a transgenic ATP1A3 DNA to the central nervous system of a mammal by administering the recombinant AAV vector into the mammal's CNS.
Type:
Grant
Filed:
April 9, 2019
Date of Patent:
August 29, 2023
Assignees:
Hope for Annabel, Cure AHC, Inc., Alternating Hemiplegia of Childhood Foundation
Inventors:
Simon Frost, Natalia Morsci, Neil Hackett, Dolan Sondhi
Abstract: A table foldable between an open and a flat position is disclosed. The table includes a table top, a modesty panel, and legs. The legs are hinged to the modesty panel so as to fold flat relative thereto. The tabletop is connected to the modesty panel by a top hinge having a pivot point offset from the modesty panel so that the tabletop can fold into a flat position over the legs when the legs are in their flat position. A lock is provided to lock the tabletop in its flat position.
Type:
Grant
Filed:
June 9, 1997
Date of Patent:
July 27, 1999
Assignee:
AHC Inc.
Inventors:
David L. Schwartz, Johnny D. Ray, Jeffrey L. Brannon
Abstract: A bacterium belonging to Bacillus subtilis and having aflatoxin decomposing ability, as well as a fungal growth inhibitor, fermentation promoter and livestock fattening agent, all containing the bacterium as an active or effective ingredient. The Bacillus subtilis is strain FERM BP-3418. Also disclosed are methods for inhibiting or controlling a pathogenic fungus on a plant or animal.
Abstract: A bacterium belonging to Bacillus subtilis and having aflatoxin decomposing ability, as well as a fungal growth inhibitor, fermentation promoter and livestock fattening agent, all containing the bacterium as an active or effective ingredient.
Abstract: A bacterium belonging to Bacillus subtilis. The bacterium being identified as Bacillus subtilis FERM BP-3418. In addition the bacterium possesses the capability of decomposing aflatoxin. It is useful as an active ingredient in products such as a fungal growth inhibitor, fermentation promoter, and livestock fattening agent.