Abstract: The current document is directed to automated-medical-imaging-system methods and systems that are controlled by machine-learning-based autonomous or semi-autonomous control systems. In one implementation, a medical-imaging system is locally controlled by a computer-based local-control system that is, in turn, controlled by a remote machine-learning-based control system that, in addition to controlling the medical-imaging system through the local-control system, provides medical-imaging information to remote-display and remote-control applications provided to medical-imaging professionals.

Abstract: The current document is directed to methods and systems that carry out deformable-image registration on two or more medical images using machine-learning and anatomical constraints. In one implementation, a first machine-learning system is used to generate a set of anatomical features within a first medical image. A second machine-learning system is used to add anatomical constraints for a selected anatomical feature to an initial map that is then updated, by a third machine-learning system, to generate a current map or transform that can be used to register a second medical image to the first medical image. The current map or transform is iteratively updated, using additional anatomical features, until improvement in the current map or transform falls below a threshold value.

Abstract: The current document is directed to digital-image-normalization methods and systems that generate accurate intensity mappings between the intensities in two digital images. The intensity mapping generated from two digital images is used to normalize or adjust the intensities in one image in order to produce a pair of normalized digital images to which various types of change-detection methodologies can be applied in order to extract differential data. Accurate intensity mappings facilitate accurate and robust normalization of sets of multiple digital images which, in turn, facilitates many additional types of operations carried out on sets of multiple normalized digital images, including change detection, quantitative enhancement, synthetic enhancement, and additional types of digital-image processing, including processing to remove artifacts and noise from digital images.

Abstract: The current document is directed to digital-image-normalization methods and systems that generate accurate intensity mappings between the intensities in two digital images. The intensity mapping generated from two digital images is used to normalize or adjust the intensities in one image in order to produce a pair of normalized digital images to which various types of change-detection methodologies can be applied in order to extract differential data. Accurate intensity mappings facilitate accurate and robust normalization of sets of multiple digital images which, in turn, facilitates many additional types of operations carried out on sets of multiple normalized digital images, including change detection, quantitative enhancement, synthetic enhancement, and additional types of digital-image processing, including processing to remove artifacts and noise from digital images.

Abstract: The current document is directed to methods and systems that refine anatomical models to sub-voxel resolution. In certain implementations, sophisticated, composite, digital anatomical atlases provide detailed three-dimensional models of the contents of three-dimensional medical images. However, three-dimensional medical images have limited resolutions characterized by a smallest volume, referred to as a voxel, to which an intensity is assigned by the imaging process. The currently disclosed methods employ computed percentages of different types of tissue within voxel volumes to adjust a three-dimensional model of the contents of the voxel volumes to more accurately model the contents of the voxel volumes.

Abstract: The current document is directed to digital-image-normalization methods and systems that generate accurate intensity mappings between the intensities in two digital images. The intensity mapping generated from two digital images is used to normalize or adjust the intensities in one image in order to produce a pair of normalized digital images to which various types of change-detection methodologies can be applied in order to extract differential data. In one approach, a mapping model is selected to provide a basis for statistically meaningful intensity normalization. In this implementation, a genetic optimization approach is used to determine and refine model parameters. The implementation produces a hybrid intensity mapping that includes both intensity mappings calculated by application of the mapping model and intensity mappings obtained directly from comparison of the images.

Abstract: The current document is directed to methods and systems that refine anatomical models to sub-voxel resolution. In certain implementations, sophisticated, composite, digital anatomical atlases provide detailed three-dimensional models of the contents of three-dimensional medical images. However, three-dimensional medical images have limited resolutions characterized by a smallest volume, referred to as a voxel, to which an intensity is assigned by the imaging process. The currently disclosed methods employ computed percentages of different types of tissue within voxel volumes to adjust a three-dimensional model of the contents of the voxel volumes to more accurately model the contents of the voxel volumes.

Abstract: The current document is directed to digital-image-normalization methods and systems that generate accurate intensity mappings between the intensities in two digital images. The intensity mapping generated from two digital images is used to normalize or adjust the intensities in one image in order to produce a pair of normalized digital images to which various types of change-detection methodologies can be applied in order to extract differential data. In one approach, a mapping model is selected to provide a basis for statistically meaningful intensity normalization. In this implementation, a genetic optimization approach is used to determine and refine model parameters. The implementation produces a hybrid intensity mapping that includes both intensity mappings calculated by application of the mapping model and intensity mappings obtained directly from comparison of the images.

Abstract: The current document is directed to digital-image-normalization methods and systems that generate accurate intensity mappings between the intensities in two digital images. The intensity mapping generated from two digital images is used to normalize or adjust the intensities in one image in order to produce a pair of normalized digital images to which various types of change-detection methodologies can be applied in order to extract differential data. In one approach, a mapping model is selected to provide a basis for statistically meaningful intensity normalization. In this implementation, a genetic optimization approach is used to determine and refine model parameters. The implementation produces a hybrid intensity mapping that includes both intensity mappings calculated by application of the mapping model and intensity mappings obtained directly from comparison of the images.