Patents Assigned to AICHI MEDICAL UNIVERSITY

Composition for Pluripotent Cell Undifferentiated State Maintenance Culture, Medium for Pluripotent Cell Undifferentiated State Maintenance Culture, Method for Pluripotent Cell Undifferentiated State Maintenance Culture, and Method for Producing Pluripotent Cells

Publication number: 20230323289

Abstract: The present invention provides a composition for pluripotent cell undifferentiated state maintenance culture and a culture method using the same, which are capable of improving the growth rate of pluripotent cells or reducing the frequency of cellular death of pluripotent cell in the pluripotent cell maintenance culture in an undifferentiated state. A composition for pluripotent cell undifferentiated state maintenance culture includes microbubbles.

Type: Application

Filed: July 9, 2021

Publication date: October 12, 2023

Applicants: Aichi Medical University, Sumitomo Seika Chemicals Co., Ltd.

Inventors: Naoyuki Hatayama, Munekazu Naito, Shuichi Hirai, Kaori Fukushige, Shunji Oyama
VASODILATOR COMPOSITION, VASODILATOR COMPOSITION KIT, PHARMACEUTICAL COMPOSITION FOR DISEASE CAUSED BY VASCULAR STENOSIS OR VASCULAR OCCLUSIVE DISORDER, AND PHARMACEUTICAL COMPOSITION KIT FOR DISEASE CAUSED BY VASCULAR STENOSIS OR VASCULAR OCCLUSIVE DISORDER

Publication number: 20230095770

Abstract: The present invention provides a vasodilator composition capable of adjusting a dosage of nitric oxide (NO). A vasodilator composition of the present invention includes microbubbles, wherein the microbubbles contain NO as a gas component.

Type: Application

Filed: January 29, 2021

Publication date: March 30, 2023

Applicant: Aichi Medical University

Inventors: Naoyuki Hatayama, Munekazu Naito, Shuichi Hirai, Kaori Fukushige
Manufacturing Method for Microbubble-Containing Electrolyte and Manufacturing Method for Microbubble-Containing Solvent for Use in Preparing Microbubble-Containing Electrolyte

Publication number: 20220387333

Abstract: The present disclosure provides a method for producing an electrolyte solution which can contain a high concentration of microbubbles, and a method for producing a microbubble-containing solvent which can be used for preparing the electrolyte solution, by suppressing decrease in microbubbles during filtration.

Type: Application

Filed: August 24, 2020

Publication date: December 8, 2022

Applicants: Aichi Medical University, Sumitomo Seika Chemicals Co., Ltd.

Inventors: Naoyuki Hatayama, Munekazu Naito, Shuichi Hirai, Kaori Fukushige, Shigeki Sakaue
Antisense nucleic acid for inhibiting biosynthesis of chondroitin sulfate

Patent number: 11479773

Abstract: The present invention provides an antisense oligonucleotide for inhibiting biosynthesis of chondroitin sulfate. The antisense oligonucleotide comprises at least one modified nucleotide, wherein the antisense oligonucleotide suppresses expression of one or both of the chondroitin sulfate N-acetylgalactosaminyltransferase-1 (CSGalNAcT1) gene and the chondroitin sulfate N-acetylgalactosaminyltransferase-2 (CSGalNAcT2) gene.

Type: Grant

Filed: February 20, 2018

Date of Patent: October 25, 2022

Assignees: Aichi Medical University, National Institutes of Biomedical Innovation, Health and Nutrition

Inventors: Satoshi Obika, Yuya Kasahara, Kosei Takeuchi
Biomaterial Preservation Composition, Method for Preserving Biomaterial, Method for Producing Biomaterial, Transplantation Material and Method of Transplantation

Publication number: 20210195887

Abstract: The present invention provides a composition that can preserve biomaterials. The biomaterial preservation composition of the present invention includes a microbubble.

Type: Application

Filed: May 31, 2019

Publication date: July 1, 2021

Applicants: Aichi Medical University, Sumitomo Seika Chemicals Co., Ltd.

Inventors: Naoyuki Hatayama, Munekazu Naito, Shuichi Hirai, Shigeki Sakaue
Antisense oligonucleotide controlling expression amount of TDP-43 and use thereof

Patent number: 11028390

Abstract: The present invention provides a suppression type antisense oligonucleotide targeting TDP-43 mRNA, containing a nucleotide sequence complementary to a sequence consisting of at least 10 continuous nucleotides in a nucleotide sequence shown in any of SEQ ID NOs: 2-4, and a promotion type antisense oligonucleotide targeting TDP-43 mRNA, containing a nucleotide sequence complementary to a sequence consisting of at least 10 continuous nucleotides in a nucleotide sequence shown in SEQ ID NO: 5.

Type: Grant

Filed: July 6, 2018

Date of Patent: June 8, 2021

Assignees: Osaka University, KNC Laboratories Co., Ltd., Aichi Medical University

Inventors: Yoshitaka Nagai, Kazuhiro Maeta, Toshihide Takeuchi, Masahiro Neya, Tsuyoshi Fujihara, Seiji Matsuda, Gen Sobue, Shinsuke Ishigaki, Kentaro Sahashi
Composition, Cell Preservation Composition, Cell Culture Composition, Cell Formulation, Method for Producing Object Including Microbubbles, Method for Preserving Cells, Method for Culturing Cells, and Method for Producing Cell Formulation

Publication number: 20210137098

Abstract: The present invention provides a composition that can preserve cells. The composition of the present invention includes a microbubble.

Type: Application

Filed: May 31, 2019

Publication date: May 13, 2021

Applicants: Aichi Medical University, Sumitomo Seika Chemicals Co., Ltd.

Inventors: Naoyuki Hatayama, Munekazu Naito, Shuichi Hirai, Kaori Fukushige, Shigeki Sakaue
ANTISENSE NUCLEIC ACID FOR INHIBITING BIOSYNTHESIS OF CHONDROITIN

Publication number: 20210102214

Abstract: The present invention provides an antisense oligonucleotide for inhibiting biosynthesis of chondroitin sulfate. The antisense oligonucleotide comprises at least one modified nucleotide, wherein the antisense oligonucleotide suppresses expression of one or both of the chondroitin sulfate N-acetylgalactosaminyltransferase-1 (CSGalNAcT1) gene and the chondroitin sulfate N-acetylgalactosaminyltransferase-2 (CSGalNAcT2) gene.

Type: Application

Filed: February 20, 2018

Publication date: April 8, 2021

Applicant: Aichi Medical University

Inventors: Satoshi OBIKA, Yuya KASAHARA, Kosei TAKEUCHI
Monoclonal antibody specifically recognizing asparagine synthetase

Patent number: 9638697

Abstract: It is an object of the present invention to provide a monoclonal antibody, which is suitable for the quantitative analysis of asparagine synthetase in a cell. The present invention provides a monoclonal antibody which specifically recognizes asparagine synthetase that is present in a cell.

Type: Grant

Filed: October 3, 2012

Date of Patent: May 2, 2017

Assignees: THE UNIVERSITY OF TOKYO, INSTITUTE OF IMMUNOLOGY CO., LTD., AICHI MEDICAL UNIVERSITY

Inventors: Takao Hamakubo, Yasuhiro Mochizuki, Hiroko Iwanari, Osamu Arai, Toshiyuki Kitoh, Masahito Tsurusawa