Patents Assigned to Aileron Therapeutics, Inc.
  • DISUBSTITUTED AMINO ACIDS AND METHODS OF PREPARATION AND USE THEREOF
    Publication number: 20140128581
    Abstract: Provided are crystalline ?, ?-disubstituted amino acids and their crystalline salts containing a terminal alkene on one of their side chains, as well as optionally crystalline halogenated and deuterated analogs of the ?, ?-disubstituted amino acids and their salts; methods of making these, and methods of using these.
    Type: Application
    Filed: November 1, 2013
    Publication date: May 8, 2014
    Applicant: Aileron Therapeutics, Inc.
    Inventors: Krzysztof Darlak, Noriyuki Kawahata, Sameer Ahmed Athamneh
  • Triazole macrocycle systems
    Patent number: 8637686
    Abstract: Provided herein are novel alkynyl and azide containing amino acids; kits containing these amino acids; peptides containing these amino acids; peptide macrocycles whose secondary structures are stabilized with linkers containing triazoles synthesized by reacting the side chains of the alkynyl and azide containing amino acids; and methods of making and using the alkynyl and azide containing amino acids, kits, peptides, triazole containing linkers, and peptide macrocycles.
    Type: Grant
    Filed: April 29, 2011
    Date of Patent: January 28, 2014
    Assignee: Aileron Therapeutics, Inc.
    Inventor: Huw M. Nash
  • Peptidomimetic macrocycles
    Patent number: 8524653
    Abstract: Biologically active crosslinked polypeptides with improved properties relative to their corresponding precursor polypeptides, having good cell penetration properties and reduced binding to human proteins, and methods of identifying and making such improved polypeptides are described.
    Type: Grant
    Filed: September 22, 2009
    Date of Patent: September 3, 2013
    Assignee: Aileron Therapeutics, Inc.
    Inventors: Huw M. Nash, David Allen Annis, Rosana Kapeller-Llbermann, Tomi K. Sawyer, Noriyuki Kawahata
  • TRIAZOLE-CROSSLINKED AND THIOETHER-CROSSLINKED PEPTIDOMIMETIC MACROCYCLES
    Publication number: 20130210745
    Abstract: Provided herein are peptidomimetic macrocycles and methods of using such macrocycles for the treatment of disease.
    Type: Application
    Filed: February 14, 2013
    Publication date: August 15, 2013
    Applicant: Aileron Therapeutics, Inc.
    Inventor: Aileron Therapeutics, Inc.
  • PEPTIDOMIMETIC MACROCYCLES
    Publication number: 20130123169
    Abstract: The present invention provides peptidomimetic macrocycles capable of modulating growth hormone levels and methods of using such macrocycles for the treatment of disease.
    Type: Application
    Filed: October 18, 2012
    Publication date: May 16, 2013
    Applicant: Aileron Therapeutics, Inc.
    Inventor: Aileron Therapeutics, Inc.
  • Peptidomimetic macrocycles
    Patent number: 8399405
    Abstract: Biologically active crosslinked polypeptides with improved properties relative to their corresponding precursor polypeptides; and methods of making and identifying such improved polypeptides.
    Type: Grant
    Filed: February 3, 2012
    Date of Patent: March 19, 2013
    Assignee: Aileron Therapeutics, Inc.
    Inventors: Huw M. Nash, David Allen Annis, Rosana Kapeller-Libermann, Tomi K. Sawyer, Noriyuki Kawahata
  • BIOLOGICALLY ACTIVE PEPTIDOMIMETIC MACROCYCLES
    Publication number: 20130023646
    Abstract: The present invention provides biologically active peptidomimetic macrocycles with improved properties relative to their corresponding polypeptides. The invention additionally provides methods of preparing and using such macrocycles, for example in therapeutic applications.
    Type: Application
    Filed: August 8, 2012
    Publication date: January 24, 2013
    Applicant: AILERON THERAPEUTICS, INC.
    Inventors: Huw M. NASH, Rosana KAPELLER-LIBERMANN, Tomi K. SAWYER, Noriyuki KAWAHATA, Vincent GUERLAVAIS, Matthew IADANZA
  • METHODS FOR PREPARING PURIFIED POLYPEPTIDE COMPOSITIONS
    Publication number: 20120264674
    Abstract: The present invention relates to purified peptidomimetic macrocycles. The invention additionally provides methods of preparing and using such macrocycles, for example in therapeutic applications.
    Type: Application
    Filed: January 13, 2012
    Publication date: October 18, 2012
    Applicant: Aileron Therapeutics, Inc.
    Inventors: Huw M. Nash, Matthew Iadanza, Christopher Leitheiser, Noriyuki Kawahata
  • TRIAZOLE MACROCYCLE SYSTEMS
    Publication number: 20120190818
    Abstract: The present invention provides novel peptidomimetic macrocycles and methods for their preparation and use, as well as amino acid analogs and macrocycle-forming linkers, and kits useful in their production.
    Type: Application
    Filed: February 9, 2012
    Publication date: July 26, 2012
    Applicant: Aileron Therapeutics, Inc.
    Inventor: Huw M. Nash
  • PEPTIDOMIMETIC MACROCYCLES
    Publication number: 20120178700
    Abstract: The present invention provides novel peptidomimetic macrocycles and methods of using such macrocycles for the treatment of disease.
    Type: Application
    Filed: September 22, 2009
    Publication date: July 12, 2012
    Applicant: Aileron Therapeutics, Inc.
    Inventors: Huw M. Nash, Rosana Kapeller-Libermann, Jiawen Han, Tomi K. Sawyer, Justin Noehre
  • PEPTIDOMIMETIC MACROCYCLES
    Publication number: 20120172311
    Abstract: The present invention provides biologically active crosslinked polypeptides with improved properties relative to their corresponding precursor polypeptides, having good cell penetration properties and reduced binding to human proteins. The invention additionally provides methods of identifying and making such improved polypeptides.
    Type: Application
    Filed: February 3, 2012
    Publication date: July 5, 2012
    Applicant: Aileron Therapeutics, Inc.
    Inventors: Huw M. Nash, David Allen Annis, Rosana Kapeller-Libermann, Tomi K. Sawyer, Noriyuki Kawahata
  • THERAPEUTIC PEPTIDOMIMETIC MACROCYCLES
    Publication number: 20120149648
    Abstract: The present invention provides biologically active peptidomimetic macrocycles for the treatment of cell proliferative disorders such as cancer and immunoproliferative disease.
    Type: Application
    Filed: January 17, 2012
    Publication date: June 14, 2012
    Applicant: Aileron Therapeutics, Inc.
    Inventors: Huw M. Nash, David Allen Annis, Rosana Kapeller-Libermann, Tomi K. Sawyer, Noriyuki Kawahata, Jiawen Han
  • PEPTIDOMIMETIC MACROCYCLES
    Publication number: 20120040889
    Abstract: The present invention provides novel peptidomimetic macrocycles and methods of using such macrocycles for the treatment of viral disease.
    Type: Application
    Filed: January 14, 2010
    Publication date: February 16, 2012
    Applicant: Aileron Therapeutics Inc.
    Inventors: Huw M. Nash, David Allen Annis
  • Methods for preparing internally constrained peptides and peptidomimetics
    Patent number: 8071541
    Abstract: The present invention relates to a method for preparing a peptide having a stable, internally constrained alpha-helical, beta-sheet/beta-turn, 310-helical, or pi-helical region and a method of stabilizing an alpha-helical, beta-sheet/beta-turn, 310-helical, or pi-helical region within a peptide structure. The resulting peptides and methods of using them are also disclosed.
    Type: Grant
    Filed: February 24, 2010
    Date of Patent: December 6, 2011
    Assignee: Aileron Therapeutics, Inc.
    Inventors: Paramjit Arora, Ross Chapman
  • TRIAZOLE MACROCYCLE SYSTEMS
    Publication number: 20110263815
    Abstract: The present invention provides novel peptidomimetic macrocycles and methods for their preparation and use, as well as amino acid analogs and macrocycle-forming linkers, and kits useful in their production.
    Type: Application
    Filed: April 29, 2011
    Publication date: October 27, 2011
    Applicant: Aileron Therapeutics, Inc., a Delaware Corporation
    Inventor: Huw M. Nash
  • PEPTIDOMIMETIC MACROCYCLES
    Publication number: 20110223149
    Abstract: The present invention provides biologically active peptidomimetic macrocycles with improved properties, such as protease resistance, relative to their corresponding polypeptides. The invention additionally provides methods of preparing and using such macrocycles, for example in therapeutic applications.
    Type: Application
    Filed: October 14, 2010
    Publication date: September 15, 2011
    Applicant: AILERON THERAPEUTICS, INC.
    Inventors: Huw M. NASH, David Allen ANNIS, Vincent GUERLAVAIS, Lawrence LICKLIDER
  • Triazole macrocycle systems
    Patent number: 7981999
    Abstract: The present invention provides novel peptidomimetic macrocycles and methods for their preparation and use, as well as amino acid analogs and macrocycle-forming linkers, and kits useful in their production. In various embodiments, the peptidomimetic macrocycles are of Formula I: The linker L includes a triazole moiety. Peptidomimetic macrocycles according to the invention may exhibit increased ?-helical or beta sheet structure in aqueous solution compared to a corresponding non-macrocyclic polypeptide.
    Type: Grant
    Filed: February 25, 2008
    Date of Patent: July 19, 2011
    Assignee: Aileron Therapeutics, Inc.
    Inventor: Huw M. Nash
  • Bis-sulfhydryl macrocyclization systems
    Patent number: 7981998
    Abstract: Peptidomimetic macrocycles and methods for their preparation and use, as well as amino acid analogs and macrocycle-forming linkers, and kits useful in their production, are provided.
    Type: Grant
    Filed: June 16, 2008
    Date of Patent: July 19, 2011
    Assignee: Aileron Therapeutics, Inc.
    Inventor: Huw M. Nash
  • Biologically Active Peptidomimetic Macrocycles
    Publication number: 20110144303
    Abstract: The present invention provides biologically active peptidomimetic macrocycles with improved properties relative to their corresponding polypeptides. The invention additionally provides methods of preparing and using such macrocycles, for example in therapeutic applications.
    Type: Application
    Filed: October 13, 2009
    Publication date: June 16, 2011
    Applicant: AILERON Therapeutics, Inc.
    Inventors: Huw M. Nash, Rosana Kapeller-Libermann, Tomi K. Sawyer, Noriyuki Kawahata, Vincent Guerlavais, Matthew Iadanza
  • Bis-sulfhydryl macrocyclization systems
    Patent number: 7960506
    Abstract: Peptidomimetic macrocycles and methods for their preparation and use, as well as amino acid analogs and macrocycle-forming linkers, and kits useful in their production, are provided.
    Type: Grant
    Filed: December 14, 2007
    Date of Patent: June 14, 2011
    Assignee: Aileron Therapeutics, Inc.
    Inventor: Huw M. Nash