Abstract: A description is given of a process for the purification of factor IX, factor X, and factor II from human plasma or fractions thereof, wherein a solution containing prothrombin complex factors is purified by repeated ion exchange chromatographic separations followed by adsorption chromatography on metal ions.
Type:
Grant
Filed:
March 26, 1993
Date of Patent:
January 3, 1995
Assignees:
Sclavo S.p.A., Aima-Derivati S.p.A.
Inventors:
Silvana Arrighi, Francesco Norelli, Maria G. Borri, Enzo Bucci