Abstract: The present application provides a process for manufacturing an orally disintegrating tablet (ODT) comprising a cytokine as an active pharmaceutical ingredient comprising: acidifying an excipient, conducting a first granulation step of the acidified excipient to obtain acidic powders, and conducting a second granulation step by mixing the acidic powders and the cytokine to obtain granules containing the cytokine. The present application also provides an ODT manufactured by the process.
Abstract: The present application provides a method for treating and/or preventing an infection of Coronavirus comprising: providing a therapeutically effective amount of a composition comprising interferon to a subject via sublingual administration and/or buccal administration; wherein the Coronavirus comprises SARS-CoV-2.