Abstract: A controller and a distal sensor module are used to emit optical emissions to a liquid sample being tested in a human body and detect desired optical data which the controller uses to electronically calculate a concentration measurement of a targeted analyte (e.g., glucose). The distal sensor module is held in place by a retention mechanism while a clamping system applies clamping pressure to the liquid sample during a test period to maintain a specified sample height of the liquid sample. An optical cable is intermediate the controller and the distal sensor module and is pluggably connected to the controller. Continuous monitoring of the analyte is possible without disconnecting the controller from the optical cable or the distal sensor module from the patient while clamping pressure on the test sample is reduced outside of the test period.

Abstract: An absorption spectroscopy process uses a single radiation beam with two or more pulsed beams (including at least a signal beam and a reference beam) that are passed into a liquid sample to a variable effective depth and then reflected out of the liquid sample where it is detected and processed to obtain a value over a preselected time. As values are determined for multiple effective depths, a sampling dataset is obtained which is used to calculate a concentration level of a targeted particle in the liquid sample by use of calibration dataset obtained from use of known samples.

Abstract: Increased precision for liquid absorption spectroscopy, especially for in vivo samples of human analytes, is obtained by varying the signal or signal and interference central wavelengths when the temperature of the sample site varies beyond a selected threshold used for determining standardized signal or signal and interference central wavelengths. The amount of variance for a central wavelength of the signal beam which includes 1,150 nm is approximately 2 nm or less.

Abstract: The concentration of a targeted molecule (such as glucose) in a liquid medium having at least one interfering molecule coexisting with the targeted molecule is detected by use of NDIR and a sampling technique in which an imposed location of a pulse beam from a signal source, an interference source and a reference source is varied over a plurality of sites of a sampling area.

Abstract: For determining concentration of targeted molecules MG in a liquid sample admixed with interfering molecules MJ which overlap their absorption band, a special NDIR sampling and calibration technique is employed. Besides the signal source, a reference and one or more interference sources are added. The selection of the wavelength for the interference sources enables its measured transmittance value to be used for deciding the validity of the calibration curve for molecules MG in the liquid sample. This value can further be used to adjust the calibration curve via a parameter linking the transmittances measured at the signal and interference wavelength channels in order to assure its validity.

Abstract: A glucose sensor measures glucose molecules in vivo through use of NDIR in which scattering noise is reduced and Absorption Interference Noise (AIN) is suppressed with a reflection technique. Electronics are used to provide an output of glucose concentration glucose in a liquid sampling matrix after it has been determined that a calibration curve is valid after signal processing is used to obtain average ratio values for reflected signal/reference channels and interference/reference channel obtained after a pulsed beam from signal, interference and reference sources is directed at an inclined angle to a normal of a spot of the liquid sampling matrix. The signal, interference and reference sources are each pulsed at a preselected frequency of at least N Hz which is sufficiently fast so that a given molecule of glucose or interfering molecule will not pass in and out of the liquid sampling matrix within the preselected frequency.

Abstract: For determining concentration of a targeted molecule M in a liquid sample admixed with interfering molecules MJ which overlap its absorption band, a NDIR reflection sampling technique is used. Besides the signal source, a reference and an interference source are added. M is calculated by electronics which use Rave(t) from a pulsed signal and reference channel output and a calibration curve which is validated by use of RJava(t2) from a pulsed interference and reference channel output. Signal, interference and reference sources are pulsed at a frequency which is sufficiently fast so that a given molecule of M or MJ will not pass in and out of the liquid sampling matrix within the pulsing frequency.

Abstract: NDIR is used to determine a concentration of a chosen molecule M in a liquid sample which contains one or more interfering molecules MJ which absorb radiation at the signal wavelength used in the NDIR process by addition of an interference source. M is calculated by electronics which use Rave(t) from a pulsed signal and reference channel output and a calibration curve which is validated by use of RJave(t2) from a pulsed interference and reference channel output. Signal, interference and reference sources are pulsed at a frequency which is sufficiently fast so that a given molecule of M or MJ will not pass in and out of the liquid sampling matrix within the pulsing frequency.

Abstract: A concentration of glucose in a blood sample is determined through use of a signal channel output/reference channel ratio obtained by use of an NDIR absorption technique in which scattering noise attributable to the liquid phase is reduced by alternately and successively pulsing infrared radiation from signal and reference sources which are multiplexed and collimated into a pulsed beam directed through the sample space containing the liquid phase and the pulse frequency is sufficiently fast so that a given molecule of glucose will not pass in and out of the sample space within the pulse frequency.

Abstract: A concentration of a chosen molecule in a liquid phase in a sample space is determined through use of a signal channel output/reference channel ratio obtained by use of an NDIR absorption technique in which scattering noise attributable to the liquid phase is reduced by alternately and successively pulsing infrared radiation from signal and reference sources which are multiplexed and collimated into a pulsed beam directed through the sample space containing the liquid phase and the pulse frequency is sufficiently fast so that a given molecule of the chosen molecule will not pass in and out of the sample space within the pulse frequency.

Abstract: An NDIR gas sensor is housed within a mechanical housing made up of a header housing, a can mounted to the header housing, and a sample chamber mounted above the can. The can has a top surface with a pair of windows formed in it to allow radiation to enter and return from the sample chamber. An electronics module is mounted on a printed circuit board hermetically sealed within the can. A signal channel path length detected by the signal detector is greater than a reference channel path length detected by the reference detector and an absorption bias between the signal and reference outputs can be used to determine a gas concentration in the sample chamber. Both the signal detector and the reference detector have an identical narrow band pass filter with the same Center Wavelength (“CWL”), Full Width Half Maximum (FWHM) and transmittance efficiency at the CWL.

Abstract: An NDIR gas sensor takes advantage of a conventional packaging embodiment commonly used to house detectors of all kinds comprising a can, header and a dish sample chamber all welded together to form a single detector unit. The can forms the top, a hollowed out header body forms the middle and a custom dish sample chamber forms the bottom of a completely functioning NDIR gas sensor. Whereas the header body not only accommodates all the optoelectronic and optical parts on its top surface providing the required signal processing functions for the gas sensor, part of its body is excavated below to accommodate a custom dish sample chamber in communication with the gas outside whose concentration level is to be measured. A lens and windows are also fabricated on the top part of this header body so that infrared radiation can enter the dish sample chamber below and then be redirected back above for signal processing.

Abstract: An NDIR gas sensor and methodology use an absorption bias between signal and reference outputs to determine sample concentration of a gas being measured. The absorption bias is created by using a signal channel in a sample chamber with a signal path length that is greater than a reference path length of a reference channel in the sample chamber while both the signal and reference detectors have an identical narrow band pass filter with the same Center Wavelength (“CWL”), Full Width Half Maximum (FWHM) and transmittance efficiency at the CWL. Performance is improved when the reference detector and the signal detector share a common thermal platform that can also be shared by the sample chamber and the infrared source.

Abstract: NDIR gas sensing methodology is advanced which renders the output of an NDIR gas sensor, when implemented with this new methodology, to remain stable or drift-free over time. Furthermore, the output of such a sensor will also be independent of the temperature of an environ wherein the sensor is in physical contact. This method utilizes the same narrow band-pass spectral filter for the detection of the gas of interest for both the signal and the reference channels. By so doing, the two channels always receive radiation of the same spectral content from the infrared source of the sensor convoluted with that from any external elements exposed to the sensor. While the same sample chamber through which the gas of interest to be detected flows is shared by the two channels, the detector package for the reference channel is hermetically sealed with 100% of the gas to be detected instead of 100% N2 as for the signal detector.