Abstract: The present invention relates to a novel method for screening for a therapeutic or prophylactic agent for an inflammatory disease. More particularly, the present invention relates to a method for screening for a therapeutic or prophylactic agent for an inflammatory disease by selecting a substance having an inhibitory activity specific to PIKfyve by using the presence or absence of the inhibitory activity as an indicator.

Abstract: Compounds represented by formula (1) and pharmaceutically acceptable salt thereofs: wherein each symbol is as defined in the specification, are useful as inhibitors of an activated blood coagulation factor X. Compositions which contain, as an active ingredient, an FXa selective low-molecular weight FXa inhibitor having a short serum half-life are particularly useful as anticoagulants for an extracorporeal blood circuit.

Abstract: The present invention provides a method for producing an L-amino acid using a bacterium of the Enterobacteriaceae family, particularly a bacterium belonging to the genus Escherichia or Pantoea, which has been modified to attenuate expression of the kefB gene.

Abstract: Herein are disclosed Chinese snacks having a proteinic adhesive layer with which transglutaminase has reacted, formed between the filling and the dumpling skin thereof, and uncooked Chinese snacks half-made in such that a proteinic adhesive layer can be formed between the filling and the dumpling skin thereof by the action of transglutaminase, as well as such Chinese snacks in the frozen form (frozen foods), which undergo a less change in eating texture and have a fresh texture maintained both at the skin portion and filling even for many hours after cooking, after thawing, or the like.

Abstract: Here is disclosed a cutter lid for a container hermetically filled with fluid content such as liquid food, e.g., stew, or granular food, e.g., table salt, characterized by that there is provided a cutter member including a knife edge adapted to cut into a top cover of the container as a foldable and rotatable grip is folded upwards. Upon raising the cutter member with the grip held, the knife edge of said cutter member cuts into the top cover of the container and rotation of the grip opens the top cover. In contrast with the pull-open type cutter lid of prior art, there is produced no force causing the container to be vertically moved and therefore the top cover of the container can be opened without any splashing of the fluid content. Furthermore, the rotatable disc provided on the upper side of the top cover to rotate the cutter member serves also as reinforcing means and decorative means for the top cover.