Patents Assigned to Ajinomoto
  • Surfactants
    Publication number: 20030162687
    Abstract: A surfactant comprising an N-long-chain acyl amino acid or a salt thereof dried by a spray dryer, which contains 280 mesh pass particles at a ratio of 3% by weight or less, and a surfactant comprising an N-long-chain acyl amino acid or a salt thereof dried by a spray dryer, which does not substantially contain 200 mesh pass particles, preferably 140 mesh pass particles. Also provided are surfactants having improved solubility and flowability, which are used for detergents and the like.
    Type: Application
    Filed: February 13, 2003
    Publication date: August 28, 2003
    Applicant: AJINOMOTO CO. INC.
    Inventors: Kazuhiko Tobita, Masatoshi Saito, Yoshinori Yamaguchi
  • Phenylalanine derivatives
    Patent number: 6610710
    Abstract: Phenylalanine derivatives of the following formula and analogues thereof have an antagonistic activity to &agr;4&bgr;7 integrin and a selectivity toward &agr;4&bgr;1 integrin. They are used as therapeutic agents for various diseases to which &agr;4&bgr;7 integrin relates.
    Type: Grant
    Filed: June 28, 2002
    Date of Patent: August 26, 2003
    Assignee: Ajinomoto Co., Inc.
    Inventors: Yasuhiro Tanaka, Toshihiko Yoshimura, Chieko Ejima, Mitsuhiko Kojima, Eiji Nakanishi, Hiroyuki Izawa, Yuko Satake, Nobuyasu Suzuki, Manabu Suzuki, Masahiro Murata
  • Dihydropyridine derivatives
    Patent number: 6610717
    Abstract: Dihydropyridine derivatives represented by the following formula: analogs thereof and pharmaceutically acceptable salts thereof have an activity of selectively inhibiting the action of N-type calcium channel, and they are used as therapeutic agents for various diseases relating to N-type calcium channel.
    Type: Grant
    Filed: December 21, 2001
    Date of Patent: August 26, 2003
    Assignee: Ajinomoto Co., Inc.
    Inventors: Akira Nakajo, Munetaka Tokumasu, Morikazu Kito, Akira Takahara, Yukitsugu Ono, Tomoko Takeda, Yuki Kajigaya, Hajime Koganei
  • Method for producing L-amino acids using bacteria belonging to the genus escherichia
    Publication number: 20030157667
    Abstract: A method for producing L-amino acid, such as L-phenylalanine and L-tryptophan, is provided using bacterium belonging to the genus Escherichia wherein the L-amino acid productivity of said bacterium is enhanced by enhancing an activity of protein encoded by the yddG gene.
    Type: Application
    Filed: November 25, 2002
    Publication date: August 21, 2003
    Applicant: Ajinomoto Co., Inc.
    Inventors: Maria Viacheslavovna Vitushkina, Vitaliy Arkadyevich Livshits, Sergei Vladimirovich Mashko, Vera Georgievna Doroshenko, Irina Vladimirovna Biryukova, Zhanna Iosifovna Katashkina, Aleksandra Yurievna Skorokhodova, Alla Valentinovna Belareva
  • Method for nucleotide sequencing
    Publication number: 20030152996
    Abstract: The present invention relates to a method for nucleotide sequencing in which a nucleotide sequence of a single nucleotide or plural nucleotides can be determined by assaying reactions in one reaction solution. The nucleotide sequence can be determined according to the present method by detecting a reaction product continuously generated in an extension reaction system following the extension reaction of polynucleotide chain and thereby determining the alignment in the sequentially extending polynucleotide.
    Type: Application
    Filed: March 10, 2003
    Publication date: August 14, 2003
    Applicant: AJINOMOTO CO. INC
    Inventor: Eiichiro Kimura
  • Method for producing L-arginine
    Publication number: 20030153058
    Abstract: A gene coding for glutamate dehydrogenase is introduced into a microorganism having L-arginine producing ability to enhance intracellular glutamate dehydrogenase activity and thereby improve the L-arginine producing ability. The present invention provides an improved method for producing L-arginine and a microorganism used therefor.
    Type: Application
    Filed: January 27, 2003
    Publication date: August 14, 2003
    Applicant: AJINOMOTO CO. INC.
    Inventors: Yoko Kuwabara, Osamu Kurahashi, Tsuyoshi Nakamatsu
  • Dry granulated product containing L-lysine as main component
    Publication number: 20030152633
    Abstract: Hydrochloric acid, sulfuric acid or an L-lysine solution having an equivalent ratio of anion/L-lysine higher than 0.95 is added to a raw material L-lysine solution having an equivalent ratio of anion/L-lysine lower than 0.68 to adjust the equivalent ratio of anion/L-lysine of the raw material solution to be in the range of 0.68 to 0.95, and the obtained L-lysine solution or a concentrate thereof is granulated and dried to obtain a dry granulated product having a high L-lysine content and showing low caking property and low hygroscopic property.
    Type: Application
    Filed: January 24, 2003
    Publication date: August 14, 2003
    Applicant: AJINOMOTO CO., INC.
    Inventors: Takeshi Kushiki, Junko Morikawa, Kazuhiko Hasegawa
  • Cutting fluid composition
    Patent number: 6605575
    Abstract: The object of the present invention is to provide a cutting oil composition excellent in solubility, lubricity, cutting properties, antirust ability, safety, and washing ability and reduced in foaming, and for that purpose, an N-acylamino acid having a long chain acyl group and/or a salt thereof, or an N-alkylamino acid having a long chain alkyl group and/or a salt thereof is used concurrently with an alkylalkylene oxide and/or an acylalkylene oxide.
    Type: Grant
    Filed: July 2, 2001
    Date of Patent: August 12, 2003
    Assignee: Ajinomoto Co., Inc.
    Inventor: Naoya Yamato
  • New mutant glutamine synthetase and method for producing amino acids
    Publication number: 20030148474
    Abstract: Amino acids, such as L-glutamine, L-arginine, L-tryptophan, L-histidine and L-glutamate are produced using a bacterium belonging to the genus Escherichia harboring a mutant glutamine synthetase in which the tyrosine amino acid residue corresponding to position 397 in a wild type glutamine synthetase is replaced with any of amino acid residues, preferably with phenylalanine.
    Type: Application
    Filed: November 20, 2002
    Publication date: August 7, 2003
    Applicant: Ajinomoto Co., Inc.
    Inventors: Mikhail Markovich Gusyatiner, Lirina Valerievna Ivanovskaya, Tatyana Viktorovna Leonova, Ekaterina Igorevna Mukhanova, Yulia Georgievna Rostova, Dmitriy Vladimirovich Filippov, Daria Aleksandrovna Chudakova
  • Mutant N-acetylglutamate synthase and method for L-arginine production
    Publication number: 20030148475
    Abstract: L-arginine is produced using a bacterium belonging to the genus Escherichia harboring a mutant N-acetylglutamate synthase in which the amino acid sequence corresponding to positions from 15 to 19 in a wild type N-acetylglutamate synthase is replaced with any one of amino acid sequences of SEQ ID NOS: 1 to 4, and feedback inhibition by L-arginine is desensitized.
    Type: Application
    Filed: June 22, 2001
    Publication date: August 7, 2003
    Applicant: AJINOMOTO CO., INC.
    Inventors: Leonid Romanovich Ptitsyn, Irina Borisovna Altman, Sergey Vasil?apos;evich Smirnov, Yulia Georgievna Rostova, Tatyana Abramovna Yampolskaya, Tatyana Viktorovna Leonova, Mikhail Markovich Gusyatiner
  • Method for producing L-amino acid using bacteria belonging to the genus escherichia
    Publication number: 20030148473
    Abstract: A method for producing an L-amino acid, such as L-phenylalanine, L-threonine is provided using bacterium belonging to the genus Escherichia wherein the L-amino acid productivity of said bacterium is enhanced by enhancing an activity of protein encoded by the yedA gene.
    Type: Application
    Filed: November 25, 2002
    Publication date: August 7, 2003
    Applicant: Ajinomoto Co., Inc.
    Inventors: Vitaliy Arkadyevich Livshits, Maria Viacheslavovna Vitushkina, Mikhail Markovich Gusyatiner, Mikhail Kharisovich Ziyatdinov, Valery Zavenovich Akhverdian, Ekaterina Alekseevna Savrasova, Vera Georgievna Doroshenko, Sergey Vladimirovich Mashko
  • Phenylalanine derivatives
    Publication number: 20030149083
    Abstract: Specified phenylalanine derivatives and analogues thereof have an antagonistic activity to &agr; 4 integrin. They are used as therapeutic agents for various diseases concerning &agr; 4 integrin.
    Type: Application
    Filed: May 20, 2002
    Publication date: August 7, 2003
    Applicant: AJINOMOTO CO. INC
    Inventors: Yasuhiro Tanaka, Toshihiko Yoshimura, Hiroyuki Izawa, Chieko Ejima, Mitsuhiko Kojima, Yuko Satake, Eiji Nakanishi, Nobuyasu Suzuki, Shingo Makino, Manabu Suzuki, Masahiro Murata
  • DNA for encoding D-hydantoin hydrolases, DNA for encoding N-carbamyl-D-amino acid hydrolases, recombinant DNA containing the genes, cells transformed with the recombinant DNA, methods for producing proteins utilizing the transformed cells and methods for producing D-amino acids
    Publication number: 20030148472
    Abstract: DNA for encoding a protein having D-hydantoinase activity which has a base sequence represented by Sequence ID No. 1 in the Sequence Listing. DNA for encoding a protein having D-carbamylase activity which has a base sequence represented by Sequence ID No. 3 in the Sequence Listing.
    Type: Application
    Filed: July 8, 2002
    Publication date: August 7, 2003
    Applicant: Ajinomoto Co., Inc.
    Inventors: Yasuhiro Takenaka, Ikuo Kira, Kenzo Yokozeki
  • Tablet composition
    Publication number: 20030147951
    Abstract: A tablet composition containing N-(trans-4-isopropylcyclobexanecarbonyl)-D-phenylalanine and low sustituted hydxoxypropylcellulose is disclosed. This tablet composition is rapidly disintegrated in the stomach after the administration and absorbed without being influenced by meals to inhibit the rise of the blood sugar levels of diabetics after meals.
    Type: Application
    Filed: February 5, 2003
    Publication date: August 7, 2003
    Applicant: AJINOMOTO CO. INC
    Inventors: Akira Yabuki, Masato Kaida, Takahiko Ando, Nobutaka Ninomiya, Masanao Ozaki
  • Method for producing xylitol
    Publication number: 20030148482
    Abstract: D-Xylulose is efficiently converted into xylitol by allowing a microorganism which is transformed with a gene encoding xylitol dehydrogenase and has an ability to supply reducing power to act on D-xylulose to produce xylitol, and collecting the produced xylitol.
    Type: Application
    Filed: October 23, 2002
    Publication date: August 7, 2003
    Applicant: AJINOMOTO CO. INC
    Inventors: Yasuhiro Takenaka, Naoto Tonouchi, Kenzo Yokozeki
  • Cysteine derivatives
    Patent number: 6602492
    Abstract: Objects of the present invention are to provide an oxidative stress inhibitor which is capable of suppressing the expression of a cytotoxic protein and the activation of a gene transcriptional regulatory factor taking part such expression of a cytotoxic protein and exhibits good feeling upon use and safety; to provide a method for preventing, retarding, alleviating or treating a skin change due to aging or an undesirable aesthetic skin change, both caused or promoted by an oxidative stress; and to provide a cosmetic composition or dermatologic preparation for external use comprising the oxidative stress inhibitor as an effective ingredient, and for those purposes are employed an oxidative stress inhibiting agent which comprises, as an effective ingredient, at least one selected from cysteine or cystine derivatives and the salts thereof.
    Type: Grant
    Filed: January 22, 2002
    Date of Patent: August 5, 2003
    Assignee: Ajinomoto Co., Inc.
    Inventors: Keiji Iwasaki, Manabu Kitazawa, Eiji Shiojiri, Kazutami Sakamoto
  • Medicament and method for treating renal disease
    Patent number: 6599876
    Abstract: A medicament for treating a renal disease, comprising a therapeutically effective amount of an activin inhibitor as an active ingredient. Also, a method for treating a renal disease, comprising administering a therapeutically effective amount of an activin inhibitor to a patient suffering from renal disease is disclosed. The activin inhibitor may be follistatin, an anti-activin antibody, an inhibitor to activin receptor or an anti-activin receptor antibody, an inhibitor to signal transduction relating to activin receptor, an activin production inhibitor in kidney, and the like.
    Type: Grant
    Filed: March 30, 2001
    Date of Patent: July 29, 2003
    Assignee: Ajinomoto Co., Inc.
    Inventor: Itaru Kojima
  • Methods for producing L-amino acids
    Publication number: 20030138918
    Abstract: A bacterium belonging to the genus Escherichia having an ability to produce an L-amino acid is cultured in a medium containing fructose as a main carbon source, preferably a medium containing a carbon source composed of 30 weight % or more of fructose and 70 weight % or less of glucose, to produce and accumulate the L-amino acid in the medium, and the L-amino acid is collected from the medium.
    Type: Application
    Filed: December 20, 2002
    Publication date: July 24, 2003
    Applicant: AJINOMOTO CO., INC.
    Inventors: Shintaro Iwatani, Masaki Kobayashi
  • Method for producing L-glutamic acid
    Patent number: 6596517
    Abstract: A method for producing L-glutamic acid by fermentation, which comprises culturing a microorganism having L-glutamic acid-producing ability at a first pH that is suitable for growth of the microorganism, and then culturing the microorganism at a second pH that is suitable for L-glutamic acid production by the microorganism and is lower than the first pH.
    Type: Grant
    Filed: February 20, 2002
    Date of Patent: July 22, 2003
    Assignee: Ajinomoto Co., Inc.
    Inventors: Hiroshi Izui, Yoshihiko Hara, Masakazu Sato, Naoki Akiyoshi
  • Method for producing L-glutamic acid by fermentation
    Publication number: 20030134397
    Abstract: A coryneform bacterium which has enhanced intracellular pyruvate carboxylase activity obtained by increasing copy number of a gene encoding the intracellular pyruvate carboxylase, or by enhancing function of a expression regulatory sequence for the gene, and has L-glutamic acid-producing ability is cultured in a medium so that L-glutamic acid should be produced and accumulated in the culture, and L-glutamic acid is collected from the culture.
    Type: Application
    Filed: December 2, 2002
    Publication date: July 17, 2003
    Applicant: AJINOMOTO CO. INC
    Inventors: Wataru Hibino, Yasuhiko Yoshihara, Masakazu Sugimoto, Harufumi Miwa