Abstract: A process for the synthesis of a new N-acetylated Heparin derivative is disclosed which includes a reaction of a N-desulfated Heparin with acetic anhydride. The new compound so obtained and pharmaceutical compositions containing it, exhibit antithrombotic and fibrinolytic properties with low anticoagulant activity.
Type:
Grant
Filed:
September 16, 1992
Date of Patent:
August 23, 1994
Assignee:
Ajorca S.A.
Inventors:
Fernando Fussi, Victor Diaz, Ricardo H. Domanico, Esteban P. Fuentes
Abstract: The present invention relates to modified heparins having antithrombotic activity.The invention also relates to a process of preparing such modified heparins starting from water insoluble heparin ammonium quaternary complexes.Finally, the invention relates to pharmaceutical compositions containing the above modified heparins.
Type:
Grant
Filed:
January 27, 1989
Date of Patent:
April 30, 1991
Assignee:
Ajorca S.A.
Inventors:
Fernando Fussi, Victor B. Diaz, Richardo H. Domanico