Abstract: The present invention relates to methods of overcoming the resistance to an EGFR (Epidermal Growth Factor Receptor)-targeting antibody through a peptide that binds specifically to neuropilin-1 (NRP1). Moreover, the present invention relates to a fusion antibody in which a peptide that binds specifically to NRP1 is fused to an EGFR-targeting antibody, and to a composition of overcoming the resistance to an EGFR-targeting antibody alone by co-administration of the EGFR-targeting antibody and an NRP1-binding peptide-fused Fc. In addition, the fusion antibody according to the present invention, in which the NRP1-specific binding peptide is fused to an EGFR-targeting antibody, overcomes the resistance to the EGFR-targeting antibody alone in pancreatic cancer. Furthermore, the fusion antibody, in which the NRP1-specific binding peptide is fused to the EGFR-targeting antibody, also overcomes resistance to the EGFR-targeting antibody alone even in lung cancer.

Abstract: A method of sharing a spectrum by frequency hopping includes receiving frequency usage information for a shared spectrum of a first communication system, setting a weight for determining a ratio of channels to be used for communication by frequency hopping of a second communication system from among first channels of the second communication system corresponding to an unused spectrum in the shared spectrum and second channels of the second communication system corresponding to a used spectrum in the shared spectrum, based on the received frequency usage information, and selecting a frequency hopping channel from among the first channels and the second channels based on the set weight.

Abstract: The present disclosure provides a method for manufacturing a surge absorbing device, the method comprising: providing an elongate ceramic tube having a hollow space defined therein and having open and opposite first and second end; forming a first plating layer and a second plating layer on the first end and the second end, respectively; placing a surge absorbing element within the hollow space within the ceramic tube; disposing first and second brazing rings on the first plating layer and the second plating layer, respectively; disposing first and second sealing electrodes on the first and second brazing rings respectively; and melting the first and second brazing rings in an inert gas atmosphere to attach the first and second sealing electrodes onto the first plating layer and the second plating layer, respectively.

Abstract: Provided is a method for generating a one class model based on a data frequency. The method for generating a one class model based on a data frequency includes: generating, by a machine learning apparatus, a plurality of spatial coordinates by arranging a plurality of learning data in corresponding coordinates in a feature space; classifying, by the machine learning apparatus, the plurality of spatial coordinates into a plurality of internal coordinates PI and a plurality of external coordinates PO based on a frequency of the learning data arranged in the respective spatial coordinates which belong to the plurality of spatial coordinates; and generating, by the machine learning apparatus, a one class model based on the plurality of internal coordinates PI based on mutual spatial distances of the plurality of external coordinates PO and the plurality of internal coordinates PI.

Abstract: The present invention relates to methods of preventing or treating skin necroptosis diseases, including administering to subjects receptor-interacting protein kinase-3 (RIP3)-mixed lineage kinase domain-like protein (MLKL) pathway blockers or dabrafenib, and method of diagnosing of skin necroptosis diseases, including detecting phosphorylated MLKL. The RIP3-MLKL pathway blockers according to the present invention directly suppress RIP3 overexpressing in skin necroptosis diseases, or inhibit phosphorylation and translocation to plasma membranes of MLKL, subsequently induced therefrom, thereby effectively preventing skin cell death via necroptosis. Thus, the present invention can prevent or treat a variety of skin diseases caused by necroptosis.

Abstract: The present invention relates to an anticancer supplement containing loperamide as an active ingredient. More specifically, a proteasome inhibitor alone cannot exhibit an anticancer effect on solid cancers and some blood cancers, but when the proteasome inhibitor and loperamide are co-administered or a composition containing the proteasome inhibitor and loperamide is provided, cancer cell death by the proteasome inhibitor can be effectively induced, thereby exhibiting an improved anticancer effect, and enhancing anticancer effects on solid cancers and blood cancers while reducing side effects caused by a high-concentration of the proteasome inhibitor. Therefore, the composition containing the proteasome inhibitor and loperamide as active ingredients, according to the present invention, can be useful for preventing or treating cancer, and loperamide can be provided as an anticancer supplement when the proteasome inhibitor is used to treat cancer.

Abstract: Provided are an injectable tissue adhesive hydrogel including gamma-cyclodextrin (?-CD). When such an injectable tissue adhesive hydrogel including the ?-CD is used as a skin glue, based on a fact that the ?-CD has a bigger hydrophobic cavity than that of ?- and ?-CDs, the injectable tissue adhesive hydrogel including the ?-CD has stronger interactions than host-guest interactions. In addition, hydrogen bonding in the injectable tissue adhesive hydrogel including the ?-CD can improve both cohesiveness and adhesiveness of gelatin. The injectable tissue adhesive hydrogel including the ?-CD having excellent cell viability is used for adhesion of a skin incision, to thereby effectively promote tissue regeneration.

Abstract: A single layered smart window may include a substrate; and a single layered coating formed on the substrate, wherein the coating includes a composite of a vanadium oxide and a low reflective material. The single layered smart window has high visible light transmittance and is capable of blocking infrared ray as a temperature is increased.

Abstract: According to an aspect of the inventive concept, there is provided a method of managing a smart-home environment by a server, including: receiving identification information and a password of a new smart device from a user terminal; generating a new group key based on the received identification information of the new smart device and identification information of an existing smart device; transmitting the new group key to the existing smart device; receiving identification information and a password from the new smart device; and comparing the identification information and the password received from the new smart device with the identification information and the password received from the user terminal, and transmitting the new group key to the new smart device according to a result of the comparison.

Abstract: The present invention relates to an anticancer supplement containing loperamide as an active ingredient. More specifically, a proteasome inhibitor alone cannot exhibit an anticancer effect on solid cancers and some blood cancers, but when the proteasome inhibitor and loperamide are co-administered or a composition containing the proteasome inhibitor and loperamide is provided, cancer cell death by the proteasome inhibitor can be effectively induced, thereby exhibiting an improved anticancer effect, and enhancing anticancer effects on solid cancers and blood cancers while reducing side effects caused by a high-concentration of the proteasome inhibitor. Therefore, the composition containing the proteasome inhibitor and loperamide as active ingredients, according to the present invention, can be useful for preventing or treating cancer, and loperamide can be provided as an anticancer supplement when the proteasome inhibitor is used to treat cancer.

Abstract: Disclosed is a method of preparing a metal oxide-graphene nanocomposite, including preparing a nanocomposite material, forming graphene flakes by pretreating the nanocomposite material, and hydrothermally synthesizing the pretreated nanocomposite material. A method of manufacturing an electrode using the metal oxide-graphene nanocomposite is also provided. According to this invention, the metal oxide-graphene nanocomposite is synthesized from inexpensive graphite through one-step processing using only a surfactant, in place of conventional methods using oxidants, reductants and high-temperature heat, thereby lowering the number of processing steps and processing costs. Also, in the fabrication of the electrode, low electrical resistance characteristic of graphene is applied as it is, in place of the conventional use of active material, conductive material and binder, thereby exhibiting desired processing efficiency without the addition of the conductive material.

Abstract: A cell reselection method and system based on a cooperative scanning of the mobile relay station and mobile stations is provided for facilitating cell reselection procedure in a Broadband Wireless Access (BWA) system. The cooperative scanning method for a moving wireless network including a mobile relay station and at least one mobile station according to the present invention includes transmitting, at the moving wireless network, a scanning request with cooperative scanning duration to a serving base station; assigning, when a scanning response, neighbor base stations to the mobile relay station and at least one mobile station; scanning, at the mobile relay station and the at least mobile station, the assigned neighbor base stations; and transmitting scanning results to the serving BS station.

Abstract: Disclosed relates to a microstrip antenna, particularly, relates to a dual band microstrip antenna including two slots. The microstrip antenna includes a conductor plate having a first hole and a substrate having a microstrip patch where slots of two different sizes are positioned, the substrate being located on a top of the conductor plate.