Abstract: The present invention is related to use of marimastat or a pharmaceutically acceptable salt, solvate or polymorph thereof in preventing or treating epileptogenesis in a subject that suffered a brain insult. Said brain insult is a stroke, traumatic brain injury, or a result of status epilepticus, evoked by structural or metabolic reasons. Marimastat or a pharmaceutically acceptable salt thereof is administered preferably within the first 24 hours after induction of epileptogenesis.

Abstract: The present invention relates to panels of biomarker microRNAs for use in methods of diagnosing Alzheimer's disease and related diseases and conditions in a subject. The methods involve assessing the level of said biomarker microRNA(s) in subject blood sample. The invention also relates to kits comprising said panels of biomarker microRNAs, methods of diagnosing Alzheimer's disease and to the use of said panels of biomarker microRNAs in diagnosis.

Abstract: The present invention relates to a genetically encoded FRET-based biosensor to monitor the activity of matrix metalloproteinase 9 (MMP-9). MMP-9 is an extracellular acting endopeptidase implicated in both physiological and pathological processes. A genetically encoded FRET biosensor anchored in the cellular membrane allows studying the proteolytic activity of MMP-9 with high spatiotemporal resolution at the exact region of MMP-9 action on the cell. Applicability of the biosensor, both in vitro and in vivo in living cells, has been demonstrated by ratiometric analysis of cleavage of the biosensor by a purified auto-activating mutant of MMP-9.

Abstract: The present invention relates to a genetically encoded FRET-based biosensor to monitor the activity of matrix metalloproteinase 9 (MMP-9). MMP-9 is an extracellular acting endopeptidase implicated in both physiological and pathological processes. A genetically encoded FRET biosensor anchored in the cellular membrane allows studying the proteolytic activity of MMP-9 with high spatiotemporal resolution at the exact region of MMP-9 action on the cell. Applicability of the biosensor, both in vitro and in vivo in living cells, has been demonstrated by ratiometric analysis of cleavage of the biosensor by a purified auto-activating mutant of MMP-9.

Abstract: The present invention relates to enaminocarbonyl compounds with the formula I. The present invention also relates to the use of compounds with the formula I for the modification of the taste of a product and/or preparation for oral administration.

Abstract: The invention provides dendrimeric compounds of the formula 1 comprising amino acids, wherein n is an integer of 1-4, T is an alkylidene —(CH2)2CONH(CH2)2- group, R2 is an —NH2 group or a moiety of a primary organic amine, and P is an amino acid and/or peptide moiety, wherein at least one hydrogen atom of at least one amino group is optionally replaced by a protective group, and a hyperbranched core compound of the formula 3, wherein T and R2 are as defined above. The invention provides also a process for the preparation of a dendrimeric compound and a hyperbranched core, wherein the process employs addition reactions of alkyl acrylate and a basic amino acid, and use of a hyperbranched core for the preparation of a dendrimeric compound comprising amino acids. The invention provides also use of dendrimeric compounds for the preparation of the medicament for inhibiting growth of bacterial cells, fungi and tumor cells.

Abstract: The invention provides dendrimeric compounds of the formula 1 comprising amino acids, wherein n is an integer of 1-4, T is an alkylidene —(CH2)2CONH(CH2)2- group, R2 is an —NH2 group or a moiety of a primary organic amine, and P is an amino acid and/or peptide moiety, wherein at least one hydrogen atom of at least one amino group is optionally replaced by a protective group, and a hyperbranched core compound of the formula 3, wherein T and R2 are as defined above. The invention provides also a process for the preparation of a dendrimeric compound and a hyperbranched core, wherein the process employs addition reactions of alkyl acrylate and a basic amino acid, and use of a hyperbranched core for the preparation of a dendrimeric compound comprising amino acids. The invention provides also use of dendrimeric compounds for the preparation of the medicament for inhibiting growth of bacterial cells, fungi and tumor cells.

Abstract: The invention relates to the lovastatin esterase enzyme immobilized on a solid support insoluble in water, the enzyme being covalently bound to a solid support activated with an at least difunctional coupling reagent, the immobilized lovastatin esterase exhibiting at least 5 times higher the hydrolytic activity towards lovastatin and salts thereof, in the presence of simvastatin and/or salts thereof, than towards simvastatin and salts thereof.

Abstract: The process of the instant invention is drawn to the synthesis of modified P-chiral nucleotide analogues in the form of pure diastereomers possessing preselected configuration at the P-atom. Oligonucleotides prepared by the method of the invention containing P-chiral compounds have enhanced hybridization and transporting properties.

Abstract: New organophosphorus mononucleoside derivatives, methods of their synthesis and methods for the synthesis of organophosphorus dinucleotide derivatives utilizing the organophosphorus mononucleosides are provided.

Abstract: Methods for the stereospecific synthesis of chirally pure organophosphorus dinucleotide derivatives and nucleoside monomer synthons used in their synthesis are provided. These methods allow for conversion of nucleoside intermediates of unchosen sense of P-chirality to nucleoside monomer synthons of chosen sense of P-chirality. Also provided are novel nucleoside intermediates useful in such methods.

Abstract: This present invention solves the problem of bending objects, particularly flat parallel ones, without employing an external force.The method according to this present invention involves subjecting the material of the object bent to a repetitive, two-phase heating and cooling process.During the first phase, the material undergoes heating with a concentrated stream of energy causing a thermal effect along the predetermined bending line and a partial plasticizing, melting and flowing out in the region of the bending line.On the other hand, the material is subjected in the second phase to being cooled at ambient terperature or, additionally, in a stream of a blown air, thereby causing the previously heated material to shrink along fibers in the direction perpendicular to the bending line due to the internal stresses created by the thermal shrinkage of the material in the heated region, and thus the deformation of the material to be permanently changed.The method is suitable for bending metal objects.

Abstract: This invention relates to a spring two states of stable equilibrium. This spring is to be used for accumulation of elastic strain energy and for setting the mutual position of movable co-acting parts. The spring consists of at least one pair of elastic strips and two shaped elements determined by the angles, the elastic strips of each pair being connected to one another, preferably at their ends, with arms of the shaped elements in such a way that between the neighboring sides of the strips there is a slot of length and a variable width. Strips are situated in relation to one another in such a way that they are inclined at an angle as determined by the inclination angle of shaped elements. The invention is applicable for clamping various parts, for instance, for closing kinematic chains, for accumulation of elastic strain energy in bumpers, as well as for ensuring the state of equilibrium of component parts of various mechanisms.

Abstract: A method for determination of the thermal conduction coefficient of a material sample comprises measurement of momentary temperature differences between two opposite surfaces of the material sample and measurement of heat supplied by a heater. Said material sample is placed in a system composed of the heater, two identical reference samples having known thermal conduction coefficient and two heat sinks. The material sample and the heater are sandwiched between the two heat sinks. All of them as so arranged are maintained in thermal contacts with each other. The measurements are made during a continuous linear change of the temperature of the two heat sinks.

Abstract: The invention solves the problem of feeding spark ignition engines with fuel and obtaining high total efficiency of engines. The method is characterized by that for supply control the signals of pressures of the medium in determined sections of the suction pipe passage are used. The fuel medium is subject to ultrasonic vibration with the frequency of from 20 kHz up to 60 kHz. The atomized medium is treated with an air stream. The device is equipped with an ultrasonic unit /1/ provided with an ultrasonic transducer /21/ to atomize the medium, connected with the control system of the fuel medium supply before feeding the medium to cylinders. The ultrasonic unit /1/ is provided with at least one intermediate channel /16/ to feed the fuel medium, connected with at least two output channels /18/ leading to the radiant surface b /20/ of the waveguide /19/ The device provides for high production yield of the mixture.

Abstract: A method for preparation of macroporous polymeric membranes consisting in placing a mixture of monomers and a radical initiator, dissolved in a porogenic inert organic solvent selected from the group comprising alcohols, estes of carboxylic acids, ketones, and their mixtures, into a space of an adapted shape formed by two temperature-controlled plates and a distance insert having the thickness corresponding to the required thickness of membrane and heating up to 80.degree. C. for 24 hours at utmost in order to carry out the radical polymerization. Azo-bis-isobutyronitrile is advantageously used as an initiator in the amount 0.05-2 wt. % related to monomers in the polymerization mixture. Cyclohexanol or its mixture containing up to 20 vol. % dodecanol are advantageously used as a porogenic solvent in the amount 40-60 vol. % in the polymerization batch.

Abstract: The invention solves the problem of measurement of internal stresses in cylindrical objects, such as axles, shafts and tubes made of material with varying non-uniform homogeneous mechanical properties. The method consists in that a beam of ultrasonic waves is thrown onto the surface of a cylindrical object being tested, said beam being refracted at an angle of 90 degrees. Next the times of passage for every type of waves are measured. On the basis of the calculated differences of the times of passage with a standard the absolute values of components of stresses are calculated. The method is applicable for non-destructive testing of properties and structure of materials and products.

Abstract: An object of the invention are macroporous polymeric membranes, suitable above all for the separation of polymers, which consists of the copolymer of a monovinyl monomer, selected from the group comprising acrylates, methacrylates, vinylpyridine, N-vinylpyrrolidone, vinyl acetate, and hydroxystyrene, with a divinyl monomer, selected from the group comprising alkylene and hydroxyalkylene diacrylates and dimethacrylates, divinylbenzene, and divinylpyridine, at the ratio of monomers of both types ranging from 5:95 to 95:5 wt. %. The membranes are formed from polymeric globular entities which have the size 0.05 to 0.5 .mu.m and are interconnected by covalent bonds, whereas communicating voids--pores occur between the globuli.The total thickness of membranes is 0.2 to 15 mm. and their specific surface area, which is measurable also in the dry state, may attain 400 m.sup.2 /g. Glycidyl methacrylate is advantageously used as the monovinyl monomer in the amount 5-80 vol. % related to the total volume of monomers.

Abstract: A meter is disclosed for measuring water content, particularly of soil. The probe (1) of the measuring device, fed with the needle electric pulse, is constituted of a set of waveguides connected parallely in the embranchment (2) with the microprocessor controller (10) of the electronic assemblies of the measuring device. Waveguides of the probe are installed in chosen layers of the material studied. The directly measured quantity is the sequence of time periods separating subsequent reflections of the electromagnetic wave propagating in the probe from the particular probe impedance discontinuties. The electromagnetic wave propagation velocity in a chosen layer of the medium is calculated on this basis, and therefrom the dielectric constant of the medium, and finally its moisture content upon which the dielectric constant depends.

Abstract: An active material for the manufacture of laser rods, having the chemical composition expressed by the formula A.sub.1+x B.sub.1-y C.sub.3-x O.sub.7-0.5 x, wherein A is barium, strontium, calcium, or a mixture thereof; B is lanthanum, yttrium, or a mixture thereof; C is gallium, aluminum, or a mixture thereof; and x and y assume both positive and negative values from -0.12 to +0.12;; and as a dopant an active element chosen from the group consisting of praseodymium, neodymium, samarium, europium, gadolinium, terbium, dysprosium, erbium, thulium and ytterbium in an amount of from 0.02 to 8.33 atomic percent.