Patents Assigned to Akira Hasegawa
  • Patent number: 5589465
    Abstract: Novel glycolipid derivatives of Formula (I): ##STR1## wherein R is a long chain alkyl, or their salts are disclosed. These compounds act as a ligand for selectin family and exhibit a remarkable inhibitory effect on the binding of selectin family to its native ligand sialyl Lewis.sup.x.
    Type: Grant
    Filed: March 1, 1995
    Date of Patent: December 31, 1996
    Assignees: Akira Hasegawa, Kanebo Ltd.
    Inventors: Hideharu Ishida, Makoto Kiso, Akira Hasegawa
  • Patent number: 5498604
    Abstract: The object of the present invention is to provide a new SLe-type sugar chain derivative represented by the following formula (I), which is useful as a pharmaceutical and which contains moranoline: ##STR1## wherein R.sub.1 represents hydrogen, a lower alkyl, a lower alkenyl or a lower alkynyl; R.sup.2 and R.sup.3 differ from each other and represent a galactosyl, sialylgalactosyl or fucosyl group; R.sub.4 represents a hydroxyl group or an acetamido group. The present invention comprises a sugar chain derivative containing a moranoline, and having a new structure. Possessing cell adhesion inhibitory activity, the compounds of the present invention antagonizes selectin, serving well in the treatment of inflammation, inflammation-associated thrombosis, asthma and rheumatism, and in the prevention and treatment of immunological diseases and cancer.
    Type: Grant
    Filed: November 17, 1994
    Date of Patent: March 12, 1996
    Assignees: Nippon Shinyaku Company, Limited, Akira Hasegawa
    Inventors: Akira Hasegawa, Makoto Kiso, Yoshiaki Yoshikuni
  • Patent number: 5380829
    Abstract: Disclosed are thioglycoside analogs of gangliosides represented by the formula ##STR1## in which Y represents a radical of the following formula ##STR2## and X represents a radical of the formula ##STR3## wherein m is an integer of 15 to 25, l is an integer of 0 to 3 and n is an integer of 11 to 15. The thioglycoside analogs are expected to exert specific enzyme-inhibitory effects.
    Type: Grant
    Filed: February 27, 1992
    Date of Patent: January 10, 1995
    Assignees: The Nisshin Oil Mills, Ltd., Akira Hasegawa
    Inventors: Akira Hasegawa, Makoto Kiso
  • Patent number: 5380832
    Abstract: Disclosed are ganglioside GM.sub.3 analogs represented by the formula ##STR1## in which X represents a radical of the following formula ##STR2## wherein at least one of R.sub.1, R.sub.2, R.sub.3 and R.sub.4 is hydrogen and the remainder is hydroxyl; ##STR3## wherein at least one of R.sub.5 and R.sub.6 is hydrogen and the remainder is methyl; ##STR4## wherein m is an integer of 15 to 25, l is an integer of 0 to 3, n is an integer of 11 to 15 and Ac represents acetyl. The ganglioside GM.sub.3 analogs are expected to possess an inhibitory activity for influenza virus.
    Type: Grant
    Filed: May 16, 1994
    Date of Patent: January 10, 1995
    Assignees: The Nisshin Oil Mills, Ltd., Akira Hasegawa
    Inventors: Akira Hasegawa, Makoto Kiso
  • Patent number: 5278300
    Abstract: 4,6-O-hydroxyphosphoryl-glucosamine derivatives as shown in the following formula [I] and their pharmaceutically-acceptable salts: ##STR1## wherein R.sub.1 and R.sub.2 represent a hydrogen atom or a hydroxy group; one of R.sub.3 and R.sub.4 represents --OCO(CH.sub.2).sub.n CH.sub.3, --CH.sub.2 (CH.sub.2).sub.n CH.sub.3, or --O--CH.sub.2 (CH.sub.2).sub.n CH.sub.3, and the other represents a hydrogen atom; l is an integer of 4-16; m is an integer of 4-16; and n is an integer of 6-18.
    Type: Grant
    Filed: December 12, 1991
    Date of Patent: January 11, 1994
    Assignees: Japan Tobacco, Inc., Akira Hasegawa
    Inventors: Akira Hasegawa, Shinichi Uesato, Tomio Ishida, Tomio Ishida
  • Patent number: 5191072
    Abstract: Lipid A monosaccharide analogues of the following general formula: ##STR1## wherein R.sub.1 is a hydrogen atom or a hydroxyl group, 1 is an integer of 8-14, m is an integer of 11-17 integer, and n is 8-14 integer.
    Type: Grant
    Filed: July 17, 1991
    Date of Patent: March 2, 1993
    Assignees: Japan Tobacco Inc., Akira Hasegawa
    Inventors: Akira Hasegawa, Makoto Kiso, Shinichi Uesato, Masanobu Suzuki, Tomio Ishida, Yutaka Saito