Patents Assigned to AKOUOS, INC.
  • AAV-mediated delivery of therapeutic antibodies to the inner ear
    Patent number: 12275960
    Abstract: Provided herein are methods that include introducing into an inner ear of a mammal a therapeutically effective amount of an adeno-associated virus (AAV) vector that includes a nucleotide sequence encoding (a) a polypeptide including an antibody heavy chain variable domain operably linked to a signal peptide and a polypeptide including an antibody light chain variable domain operably linked to a signal peptide; (b) a polypeptide including an antigen-binding antibody fragment operably linked to a signal peptide; or (c) a soluble vascular endothelial growth factor receptor operably linked to a signal peptide.
    Type: Grant
    Filed: June 13, 2023
    Date of Patent: April 15, 2025
    Assignee: Akouos, Inc.
    Inventors: Emmanuel John Simons, Robert Ng, Michael McKenna
  • Compositions and methods for treating non-age-associated hearing impairment in a human subject
    Patent number: 12264317
    Abstract: Provided herein are compositions that include at least two different nucleic acid vectors, where each of the at least two different vectors includes a coding sequence that encodes a different portion of an otoferlin protein, and the use of these compositions to treat hearing loss in a subject.
    Type: Grant
    Filed: July 18, 2024
    Date of Patent: April 1, 2025
    Assignee: Akouos, Inc.
    Inventors: Emmanuel John Simons, Ellen Reisinger, Sebastian Kügler, Hanan Al-Moyed
  • Methods of treating non-syndromic sensorineural hearing loss
    Patent number: 12226493
    Abstract: Provided herein are compositions that include at least two different nucleic acid vectors, where each of the at least two different vectors includes a coding sequence that encodes a different portion of a stereocilin protein, and the use of these compositions to treat non-syndromic sensorineural hearing loss in a subject.
    Type: Grant
    Filed: July 12, 2019
    Date of Patent: February 18, 2025
    Assignee: Akouos, Inc.
    Inventors: Emmanuel John Simons, Robert Ng
  • AAV-mediated delivery of antibodies to the inner ear
    Patent number: 12077783
    Abstract: Provided herein are methods that include introducing into an inner ear of a mammal a therapeutically effective amount of an adeno-associated virus (AAV) vector that includes a nucleotide sequence encoding (a) a polypeptide including an antibody heavy chain variable domain operably linked to a signal peptide and a polypeptide including an antibody light chain variable domain operably linked to a signal peptide; (b) a polypeptide including an antigen-binding antibody fragment operably linked to a signal peptide; or (c) a soluble vascular endothelial growth factor receptor operably linked to a signal peptide.
    Type: Grant
    Filed: March 17, 2022
    Date of Patent: September 3, 2024
    Assignee: Akouos, Inc.
    Inventors: Emmanuel John Simons, Robert Ng, Michael McKenna
  • Compositions and methods for treating non-age-associated hearing impairment in a human subject
    Patent number: 12077773
    Abstract: Provided herein are compositions that include at least two different nucleic acid vectors, where each of the at least two different vectors includes a coding sequence that encodes a different portion of an otoferlin protein, and the use of these compositions to treat hearing loss in a subject.
    Type: Grant
    Filed: October 11, 2023
    Date of Patent: September 3, 2024
    Assignee: Akouos, Inc.
    Inventors: Emmanuel John Simons, Robert Ng
  • Compositions and methods for treating non-age-associated hearing impairment in a human subject
    Patent number: 12071627
    Abstract: Provided herein are compositions that include at least two different nucleic acid vectors, where each of the at least two different vectors includes a coding sequence that encodes a different portion of an otoferlin protein, and the use of these compositions to treat hearing loss in a subject.
    Type: Grant
    Filed: August 30, 2023
    Date of Patent: August 27, 2024
    Assignee: Akouos, Inc.
    Inventors: Emmanuel John Simons, Ellen Reisinger, Sebastian Kügler, Hanan Al-Moyed
  • Compositions and methods for treating non-age-associated hearing impairment in a human subject
    Patent number: 11993777
    Abstract: Provided herein are compositions that include at least two different nucleic acid vectors, where each of the at least two different vectors includes a coding sequence that encodes a different portion of an otoferlin protein, and the use of these compositions to treat hearing loss in a subject.
    Type: Grant
    Filed: August 30, 2023
    Date of Patent: May 28, 2024
    Assignee: Akouos, Inc.
    Inventors: Emmanuel John Simons, Ellen Reisinger, Sebastian Kügler, Hanan Al-Moyed
  • Compositions and methods for treating non-age-associated hearing impairment in a human subject
    Patent number: 11807867
    Abstract: Provided herein are compositions that include at least two different nucleic acid vectors, where each of the at least two different vectors includes a coding sequence that encodes a different portion of an otoferlin protein, and the use of these compositions to treat hearing loss in a subject.
    Type: Grant
    Filed: July 29, 2022
    Date of Patent: November 7, 2023
    Assignee: Akouos, Inc.
    Inventors: Emmanuel John Simons, Robert Ng
  • Compositions and methods for treating non-age-associated hearing impairment in a human subject
    Patent number: 11781145
    Abstract: Provided herein are compositions that include at least two different nucleic acid vectors, where each of the at least two different vectors includes a coding sequence that encodes a different portion of an otoferlin protein, and the use of these compositions to treat hearing loss in a subject.
    Type: Grant
    Filed: September 2, 2022
    Date of Patent: October 10, 2023
    Assignee: Akouos, Inc.
    Inventors: Emmanuel John Simons, Ellen Reisinger, Sebastian Kügler, Hanan Al-Moyed
  • AAV-mediated delivery of therapeutic antibodies to the inner ear
    Patent number: 11697801
    Abstract: Provided herein are methods that include introducing into an inner ear of a mammal a therapeutically effective amount of an adeno-associated virus (AAV) vector that includes a nucleotide sequence encoding (a) a polypeptide including an antibody heavy chain variable domain operably linked to a signal peptide and a polypeptide including an antibody light chain variable domain operably linked to a signal peptide; (b) a polypeptide including an antigen-binding antibody fragment operably linked to a signal peptide; or (c) a soluble vascular endothelial growth factor receptor operably linked to a signal peptide.
    Type: Grant
    Filed: August 3, 2021
    Date of Patent: July 11, 2023
    Assignee: Akouos, Inc.
    Inventors: Emmanuel John Simons, Robert Ng, Michael McKenna
  • Compositions and methods for treating non-age-associated hearing impairment in a human subject
    Patent number: 11525139
    Abstract: Provided herein are compositions that include at least two different nucleic acid vectors, where each of the at least two different vectors includes a coding sequence that encodes a different portion of an otoferlin protein, and the use of these compositions to treat hearing loss in a subject.
    Type: Grant
    Filed: July 16, 2021
    Date of Patent: December 13, 2022
    Assignee: Akouos, Inc.
    Inventors: Emmanuel John Simons, Ellen Reisinger, Sebastian Kügler, Hanan Al-Moyed
  • A METHOD FOR TREATING AN AUDITORY NEUROPATHY SPECTRUM DISORDER
    Publication number: 20220000972
    Abstract: The present invention provides a method for treating an auditory neuropathy spectrum disorder in a subject comprising transferring the gene of DFNB59 via an adeno-associated virus (AAV) vector to the subject.
    Type: Application
    Filed: September 27, 2019
    Publication date: January 6, 2022
    Applicants: AKOUOS, INC.
    Inventors: Yen-Fu Cheng, Chen-Chi Wu, Ying-Chang Lu