Abstract: Provided herein are compositions that include at least two different nucleic acid vectors, where each of the at least two different vectors includes a coding sequence that encodes a different portion of an otoferlin protein, and the use of these compositions to treat hearing loss in a subject.
Type:
Grant
Filed:
August 30, 2023
Date of Patent:
May 28, 2024
Assignee:
Akouos, Inc.
Inventors:
Emmanuel John Simons, Ellen Reisinger, Sebastian Kügler, Hanan Al-Moyed
Abstract: Provided herein are compositions that include at least two different nucleic acid vectors, where each of the at least two different vectors includes a coding sequence that encodes a different portion of an otoferlin protein, and the use of these compositions to treat hearing loss in a subject.
Abstract: Provided herein are compositions that include at least two different nucleic acid vectors, where each of the at least two different vectors includes a coding sequence that encodes a different portion of an otoferlin protein, and the use of these compositions to treat hearing loss in a subject.
Type:
Grant
Filed:
September 2, 2022
Date of Patent:
October 10, 2023
Assignee:
Akouos, Inc.
Inventors:
Emmanuel John Simons, Ellen Reisinger, Sebastian Kügler, Hanan Al-Moyed
Abstract: Provided herein are methods that include introducing into an inner ear of a mammal a therapeutically effective amount of an adeno-associated virus (AAV) vector that includes a nucleotide sequence encoding (a) a polypeptide including an antibody heavy chain variable domain operably linked to a signal peptide and a polypeptide including an antibody light chain variable domain operably linked to a signal peptide; (b) a polypeptide including an antigen-binding antibody fragment operably linked to a signal peptide; or (c) a soluble vascular endothelial growth factor receptor operably linked to a signal peptide.
Type:
Grant
Filed:
August 3, 2021
Date of Patent:
July 11, 2023
Assignee:
Akouos, Inc.
Inventors:
Emmanuel John Simons, Robert Ng, Michael McKenna
Abstract: Provided herein are compositions that include at least two different nucleic acid vectors, where each of the at least two different vectors includes a coding sequence that encodes a different portion of an otoferlin protein, and the use of these compositions to treat hearing loss in a subject.
Type:
Grant
Filed:
July 16, 2021
Date of Patent:
December 13, 2022
Assignee:
Akouos, Inc.
Inventors:
Emmanuel John Simons, Ellen Reisinger, Sebastian Kügler, Hanan Al-Moyed
Abstract: The present invention provides a method for treating an auditory neuropathy spectrum disorder in a subject comprising transferring the gene of DFNB59 via an adeno-associated virus (AAV) vector to the subject.
Type:
Application
Filed:
September 27, 2019
Publication date:
January 6, 2022
Applicants:
AKOUOS, INC.
Inventors:
Yen-Fu Cheng, Chen-Chi Wu, Ying-Chang Lu