Abstract: This invention provides non-steroidal compounds with affinity for the androgen receptor and utility for androgen-receptor related treatments, having a structure according to the formula or a salt or hydrate form thereof.

Abstract: The present invention relates to a method for the isolation of proteins that comprise disulfide-bonds in their native conformation. Essentially, a method of the present makes the use of reducing agents such as ?-mercaptoethanol or dithiothreitol in protein isolation methods obsolete. A method of the present invention is particularly suitable for the isolation of precursor proteins such as proinsulin from recombinant cells.

Abstract: The present invention generally relates to aqueous, acidic compositions thickened with an amidoamine oxide gelling agent and/or viscoelastic surfactant of the general formula I: wherein R1 is a saturated or unsaturated, straight or branched chain aliphatic group of from about 7 to about 30 carbon atoms, R2 is a divalent alkylene group of 2–6 carbon atoms which may be linear or branched, substituted or unsubstituted, and R3 and R4 are independently C1–C4 alkyl or hydroxyalkyl groups or together they form a heterocyclic ring of up to six members, and R5 is hydrogen or a C1–C4 alkyl or hydroxyalkyl group. The aforementioned gelling agents advantageously provide gels that do not undergo phase separation over extended periods of time and exhibit high heat stability. The thickened acid gels of the invention have applications in household and industrial cleaners and degreasers, oilfield stimulation applications and the like.

Abstract: The present invention relates to isolated DNA encoding novel estrogen receptors, the proteins encoded by said DNA, chimeric receptors comprising parts of said novel receptors and uses thereof.

Abstract: The present invention relates to novel Equine herpesvirus (EHV) mutants comprising one or more deletions, substitutions, or insertions in the endogenous promoter region of an essential viral gene, preferably the immediate early gene of EHV. The EHV mutants are stable and have reduced virulence, which makes them very suitable for use in a live vaccine. The invention furthermore relates to live vaccines comprising said EHV mutants, to DNA sequences and vectors harbouring a mutated EHV sequence, to host cells transfected with said DNA or vectors. The invention also relates to a method of attenuating EHV in general, and EHV-1 in particular.

Abstract: A plastic container for the storage and transport of liquids, particularly aggressive liquids, comprising a practically rectangular bottom, a top wall with a filling or pouring hole, and standing walls which each connect to the circumferential seam of both the bottom and the top, and four standing edge strips each connecting two walls, which container is manufactured by the blow-molding process, wherein the standing wall portions have a convex form, wherein either the standing edge strips widen at the top and the bottom and, as seen in a cross-section running parallel to the bottom, the standing edge strips have a radius of curvature equal to or greater than that of the standing wall portions to which they are connected.

Abstract: The invention relates to a polymerization process wherein at least one peroxide, with a half life in between 1 hour and 0.001 hour at the polymerization temperature at the moment of dosing, is dosed to the reaction mixture at the polymerization temperature and wherein at least during part of the period in which the peroxide is dosed i) the cooling means of the reactor are kept at essentially maximum cooling capacity and ii) the amount of initiator that is dosed is actively controlled such that the desired polymerization temperature is achieved and maintained within 0.3° C. of said polymerization temperature.

Abstract: The invention relates to a process for the production of chlorine dioxide in an apparatus comprising a reaction vessel holding a reaction medium and a circulation conduit leading through a heater for the reaction medium, said process comprising the steps of continuously: a) maintaining the reaction medium at subatmospheric pressure and a temperature sufficient for evaporating water; b) circulating reaction medium through the circulation conduit and the heater; c) reacting alkali metal chlorate, sulfuric acid and hydrogen peroxide in the reaction medium to form chlorine dioxide, oxygen and alkali metal sulfate; d) feeding alkali metal chlorate, sulfuric acid and hydrogen peroxide to the reaction medium, wherein the sulfuric acid is fed through an inlet into the circulation conduit and the hydrogen peroxide is fed through an inlet directly into the reaction vessel or through an inlet into the circulation conduit down-streams the inlet for sulfuric acid at a distance in the flow direction therefrom of at least a

Abstract: The invention relates to a pigment composition in the form of an aqueous dispersion or slurry comprising: (c) porous aggregates formed by aggregation of colloidal primary particles of silica, aluminosilicate or a mixture thereof in an aqueous sol, said porous aggregates having a mean diameter from about 0.03 to about 25 ?m, and, (d) extender particles where the mean size of at least one dimension is larger than the mean diameter of the porous aggregates, wherein the weight ratio of porous aggregates to extender particles is from about 0.01:1 to about 3:1. The invention further relates to a process for its production, a composition for coating paper or paper board and a process for its production, and a process for coating paper or paper board and paper or paper board obtainable by the process.

Abstract: The invention relates to a process for the manufacture of diethylenetriamine and higher polyethylenepolyamines by a transamination of ethylenediamine. The transamination is performed at a temperature from 135° C. to 180° C. at a pressure from 5 Mpa to 40 Mpa in the presence of hydrogen and a particulate catalysts containing 26 to 65% by weight of nickel on an oxide carrier. A high conversion degree of ethylenediamine and a high selectivity to form acyclic polyethylenepolyamines, such as diethylenetriamine are obtained by the process. The formation of cyclic amine compounds, e.g. piperazine, is low.

Abstract: The invention relates to a spray gun for application of a coating having a spray nozzle and at least one actinic radiation outlet, characterized in that the at least one actinic radiation outlet is positioned externally and the radiation outlet and the spray nozzle are simultaneously directable to a substrate to be coated, and to a process of applying a coating composition which is at least partly curable by actinic radiation. The spray gun according to the invention is suitable for all types of actinic radiation-curable coating compositions, even if there is no induction period between the initiation by actinic radiation and the actual onset of the curing reaction. The balance of flow of the coating material just after application and the drying speed are particularly favourable.

Abstract: The present invention pertains to a process for the preparation of a liquid stabilizer for imparting heat stability to polyvinyl chloride compositions which is essentially solvent-free, comprising the steps of reacting one or more carboxylic acids with one or more metal sources in the presence of one or more organophospite ester-reactive solvents while stripping off water, wherein the metal in said metal source is selected from the group consisting of Ca, Ba, Zn, Sr, K, and Cd; adding one or more organophosphite esters selected from the group consisting of triorganic phosphites, organic acid phosphites, diphosphites, and polyphosphites, and reacting the one or more organophosphite ester-reactive solvents with said organophosphite esters, while distilling off phenol; and, optionally, adding one or more additives known in the art before, during, or after the addition of the one or more organophosphite esters to the reaction mixture.

Abstract: The invention relates to a process for the production of paper or nonwoven fibres comprising the steps of adding thermally expandable microspheres comprising a thermoplastic polymer shell and a propellant entrapped therein to a stock comprising fibres or to a web of fibres, forming paper or nonwoven from the stock or the web, and applying heat to raise the temperature of the microspheres sufficiently for them to expand and thereby increase the bulk of the paper or the nonwoven, wherein said expandable microspheres comprise from about 17 to about 40 wt % propellant and have a volume-average diameter from about 17 to about 35 µm. The invention also concerns certain expandable microspheres and use thereof.

Abstract: The invention relates to a process to increase the amount of TiCI4 that is retrieved from a waste stream comprising one or more titanium (halo) (alk) oxides while also reducing the quantity and/or hazard of the resulting waste. Valuable solvents/diluents and/or alkyl halides that are introduced into or formed during the process can also be retrieved. The so obtained TiCI4, solvents/diluents and/or alkyl halides are recyclable to, for instance, the process to make Ziegler-Natta catalysts and or co-catalysts.

Abstract: The invention relates to a coating composition comprising an acetal-functional binder and a thiol-functional cross-linker, wherein the acetal-functional binder is represented by the following formula wherein P is a binder backbone, K is a divalent and/or trivalent organic moiety having 1 to 30 carbon atoms and having one or two links to the binder backbone, A is selected from oxygen, sulphur, and NRVII, wherein RVII is hydrogen or an alkyl group with 1 to 4 carbon atoms, m is an integer from 1 to 50, n is an integer from 1 to 10, and R and R? may be the same or different and represent alkyl groups with 1 to 4 carbon atoms. In a further aspect, the invention relates to acetal-functional binders, acetal-functional monomers, a process for the preparation of said monomers, coating compositions comprising said acetal-functional binders, and to a process for the preparation of a coating composition comprising an acetal-functional polyurethane dispersion and a thiol-functional cross-linker.

Abstract: The present invention relates to live attenuated Salmonella strains comprising a first attenuating mutation, that are not capable of making functional RecA. The invention also relates to these bacteria for use in vaccines. Furthermore, the invention relates to vaccines based upon these bacteria, to the use of such bacteria in the manufacture of vaccines and to methods for the preparation of such vaccines.

Abstract: The present invention relates to a method of treating cellulose fibres. The invention further involves the production of paper from said treated fibres and the paper obtainable therefrom. The invention also relates to the use of a cellulose derivative as an additive to an acidic bleaching stage.

Abstract: The present invention relates to a pigment composition in the form of an aqueous dispersion comprising: (d) pigment particles of synthetic amorphous silica or aluminosilicate; (e) at least one water soluble aluminium salt; and, (f) at least one cationic polymer having a molecular weight from about 2000 to about 1000000 and a charge density from about 0.2 to about 12 meq/g. The invention further relates to a process for its production, use thereof, a process for coating paper or paper board and paper or paper board obtainable by the process.

Abstract: The present invention relates to a process for the production of coated paper or paperboard comprising a step of applying a pigment composition as a coating to at least one side of a paper or paperboard web, said pigment composition being an aqueous dispersion comprising as pigment particles optionally aggregated colloidal particles of silica or aluminosilicate prepared from alkali metal silicate by ion exchange or pH-reduction and having a surface area from about 30 m2/g to about 450 m2/g, and at least one cationic component selected from the group consisting of water soluble aluminium salts and cationic polymers with a molecular weight from about 2000 to about 1000000 and a charge density from about 0.2 meq/g to about 12 meq/g, wherein at least about 0.4 g pigment particles from the pigment composition are applied per m2 coated side of the paper or paper board web.

Abstract: The present invention is directed to attenuated pestivirus mutants, which have a reduced ability to replicate as exhibited by a small plaque size. The mutations are in the 5? nontranslated region of the viral genome. These mutant viruses are useful as live vaccines in the control of bovine viral diarrhea, border disease and classical swine fever.