Abstract: A handheld, portable devices with integrated artificial intelligence (AI) configured to assess a patient's body part to detect a disease and methods of operating such devices are disclosed. In some cases, a device can be a retina camera configured to assess a patient's retina and, by using an on-board AI retinal disease detection system, provide real-time analysis and diagnosis of the patient's retina. Easy and comfortable visualization of the patient's retina can be facilitated using such retina camera, which can be placed over the patient's eye, display the retina image on a high-resolution display, analyze a captured image by the on-board AI system, and provide determination of presence of a disease.