Abstract: Benzo(e)perimidine-4-carboxamide derivatives of general structural formula I ##STR1## (where R.sub.a, R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, and R.sup.6 are as defined in the specification) have activity for receptors of corticotropin releasing factor (CRF). The compounds are useful in treating stress-related diseases, cardiovascular, neurological and psychiatric disorders including anxiety, depression, eating disorders, anorexia nervosa, superanuclear palsy, irritable bowel syndrome, gastrointestinal diseases, immune suppression, inflammatory disorders, drug and alcohol withdrawal symptoms, drug addiction, Alzheimer's disease or fertility disorders.

Abstract: A system for preparative sorption driven chromatographic separation of organic compounds comprising a chromatographic element having a focusing zone in a porous tip with a vertex having a first diameter for receiving sample and solvent and a base having a wider second diameter, and an elongated resolving zone of at least the second diameter is disclosed. The system may further include a porous solvent transfer block for transferring solvent from a source to the tip. A method of chromatographically isolating an organic compound using the system is disclosed.