Patents Assigned to Alaylam Pharmacueuticals, Inc.
  • 5?-end derivatives
    Patent number: 9725479
    Abstract: The present invention provides compounds of formula (1). Another aspect of the invention relates to a method of inhibiting the expression of a gene in call, the method comprising (a) contacting an oligonucleotide of the invention with the cell; and (b) maintaining the cell from step (a) for a time sufficient to obtain degradation of the mRNA of the target gene.
    Type: Grant
    Filed: April 22, 2011
    Date of Patent: August 8, 2017
    Assignees: Ionis Pharmaceuticals, Inc., Alaylam Pharmacueuticals, Inc.
    Inventors: Muthiah Manoharan, Kallanthottathil G. Rajeev, Ivan Zlatev, Eric E. Swayze, Thazha P. Prakash, Walter F. Lima