Patents Assigned to Albert Einstein College of Medicine of Yeshiva University
  • Patent number: 10189827
    Abstract: Compounds, compositions and methods are provided for selectively activating chaperone-mediated autophagy (CMA), protecting cells from oxidative stress, proteotoxicity and lipotoxicity, and/or antagonizing activity of retinoic acid receptor alpha (RAR?) in subjects in need thereof.
    Type: Grant
    Filed: January 10, 2018
    Date of Patent: January 29, 2019
    Assignee: ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY
    Inventors: Ana Maria Cuervo, Evripidis Gavathiotis, Qisheng Xin, Bhaskar C. Das
  • Publication number: 20160032383
    Abstract: Methods are provided for determining if a subject is likely to develop an age-related disease based on miRNA signatures. Related methods of treatment are also provided.
    Type: Application
    Filed: March 14, 2014
    Publication date: February 4, 2016
    Applicant: ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY
    Inventor: Yousin SUH
  • Publication number: 20160010134
    Abstract: Methods and systems for identifying inhibitors of Equilibrative Nucleoside Transporters are provided. Methods and systems for identifying inhibitors of Concentrative Nucleoside Transporters are also provided.
    Type: Application
    Filed: January 8, 2014
    Publication date: January 14, 2016
    Applicant: ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY
    Inventors: Myles Akabas, Ithiel James Frame, Roman Deniskin
  • Publication number: 20160002337
    Abstract: Provided are methods of treating an autoimmune disease in a subject, or of suppressing transplant rejection in a subject, or of treating a cancer in a subject, as well as compositions therefor.
    Type: Application
    Filed: February 7, 2014
    Publication date: January 7, 2016
    Applicant: ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY
    Inventor: Xingxing Zang
  • Publication number: 20150366942
    Abstract: The invention provides methods of regulating smooth muscle tone in a subject, comprising the introduction, into smooth muscle cells of the subject, of a DNA sequence encoding a potassium channel protein involved in the regulation of smooth muscle tone, and expression of the DNA sequence in a sufficient number of smooth muscle cells of the subject to regulate smooth muscle tone in the subject. The invention provides methods of gene transfer for treating erectile dysfunction, bladder dysfunction, and other smooth muscle disorders.
    Type: Application
    Filed: September 2, 2015
    Publication date: December 24, 2015
    Applicant: Albert Einstein College of Medicine of Yeshiva University
    Inventors: George J. Christ, Kelvin Davies, Arnold Melman
  • Publication number: 20150368316
    Abstract: Isolated polypeptides comprising a mutant programmed cell death 1 (PD-1) polypeptide and fusion polypeptides comprising an isolated mutant PD-1 polypeptide fused to an immunoglobulin domain polypeptide are provided. Further provided are methods of using a composition comprising the fusion polypeptide for stimulating T cell activation for treating disorders including a tumor or an infection.
    Type: Application
    Filed: February 7, 2014
    Publication date: December 24, 2015
    Applicant: ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY
    Inventors: Eszter LAZAR-MOLNAR, Steven C. ALMO
  • Publication number: 20150359815
    Abstract: Methods are disclosed for treating acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS) using inhibition of p21 protein (Cdc42/Rac)-activated kinase (PAK1).
    Type: Application
    Filed: September 4, 2015
    Publication date: December 17, 2015
    Applicant: ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY
    Inventors: ULRICH G. STEIDL, ASHLEY M. PANDOLFI, ROBERT F. STANLEY
  • Publication number: 20150335671
    Abstract: Methods are provided for identifying an agent as a selective inhibitor of a Bcl-2-associated x-protein (BAX).
    Type: Application
    Filed: January 13, 2014
    Publication date: November 26, 2015
    Applicant: ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY
    Inventors: Evripidis Gavathiotis, Thomas Garner
  • Publication number: 20150329643
    Abstract: Methods are provided for diagnosing and treating a blood cancer or a myelodysplastic syndrome in a subject. Associated compositions and kits therefor are also provided.
    Type: Application
    Filed: November 15, 2013
    Publication date: November 19, 2015
    Applicant: ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY
    Inventors: Ulrich Steidl, Christian Steidl, Cynthia Ujunwa Okoye-Okafor
  • Publication number: 20150313935
    Abstract: Methods and compositions are disclosed that enhance delivery of nitric oxide (NO) by combining nitric oxide releasing nanoparticles (NO-np) with exogenous glutathione (GSH), as well as therapeutic uses of the methods and compositions.
    Type: Application
    Filed: July 15, 2015
    Publication date: November 5, 2015
    Applicant: Albert Einstein College of Medicine of Yeshiva University
    Inventors: Adam Friedman, Joel Friedman, Joshua Nosanchuk, Parimala Nacharaju, Karin Blecher, Chaim Tuckman-Vernon
  • Publication number: 20150306177
    Abstract: Methods are disclosed for therapy of radiation-induced lung injury and other lung diseases using R-spondin1.
    Type: Application
    Filed: March 24, 2015
    Publication date: October 29, 2015
    Applicant: ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY
    Inventors: Chandan Guha, Subhrajit Saha
  • Publication number: 20150299336
    Abstract: Methods are provided for treating a cancer in a subject comprising administering to the subject an agent which inhibits expression of an HLX gene in the subject, or an agent which inhibits activity of an expression product of the HLX gene, and also for diagnosing a subject as likely to develop a cancer comprising determining whether a stem cell obtained from the subject expresses a HLX gene at a level in excess of predetermined control level. Kits therefor are also provided.
    Type: Application
    Filed: March 26, 2015
    Publication date: October 22, 2015
    Applicant: Albert Einstein College of Medicine of Yeshiva University
    Inventor: Ulrich G. Steidl
  • Publication number: 20150290250
    Abstract: Methods and products are provided for producing an artery-specific endothelial cell. Also provided are methods for treating a tumor in a subject.
    Type: Application
    Filed: November 20, 2013
    Publication date: October 15, 2015
    Applicant: ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY
    Inventors: Bin Zhou, Bingrou Wu
  • Patent number: 9150534
    Abstract: Fluorinated prodrug compounds as can be used for selective streptococcal mevalonate pathway inhibition.
    Type: Grant
    Filed: February 28, 2013
    Date of Patent: October 6, 2015
    Assignees: Northwestern University, Albert Einstein College of Medicine of Yeshiva University
    Inventors: Richard B. Silverman, Mizuki Watanabe, Soosung Kang, Thomas S. Leyh
  • Patent number: 9144573
    Abstract: The present invention generally relates to prostaglandin transport. More specifically, the invention is directed to compounds that inhibit prostaglandin transport and subsequent COX-2 induction, and methods relating thereto.
    Type: Grant
    Filed: July 23, 2012
    Date of Patent: September 29, 2015
    Assignees: Albert Einstein College of Medicine of Yeshiva University, New York University
    Inventors: Victor L. Schuster, Yuling Chi, Young-Tae Chang, Jaeki Min
  • Patent number: 9139809
    Abstract: The invention is directed compositions and methods related to bacterial cells physically associated with ceramide-like glycolipids. The invention allows for delivery of ceramide-like glycolipid adjuvants directly to the same cells that become infected with a bacterial vaccine. The compositions and methods of the present invention are useful for the prevention and treatment of diseases.
    Type: Grant
    Filed: January 8, 2010
    Date of Patent: September 22, 2015
    Assignee: Albert Einstein College of Medicine of Yeshiva University
    Inventors: Steven A. Porcelli, Manjunatha M. Venkataswamy
  • Publication number: 20150260714
    Abstract: The present invention relates to methods and kits for detecting active tuberculosis infection in a subject using serological techniques and a first agent capable of binding an IgG, IgA and/or IgM directed to the first protein present in or on a Mycobacterium tuberculosis membrane vesicle or a Bacillus Calmette-Guerin (BCG) membrane vesicle. Also provided are methods of treating a subject with an active tuberculosis disease.
    Type: Application
    Filed: October 10, 2013
    Publication date: September 17, 2015
    Applicant: ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY
    Inventors: Jacqueline Michele Achkar, Arturo Casadevall, Rafael Prados-Rosales, Anke Ziegengalg
  • Publication number: 20150238532
    Abstract: A method of obtaining a population of PDGFR?+ CD51+ CD146high stem cells is provided. Compositions comprising PDGFR?+ CD51+ CD146high stem cells, and methods of use of a population of PDGFR?+CD51+ CD146high stem cells, are also provided.
    Type: Application
    Filed: July 1, 2013
    Publication date: August 27, 2015
    Applicant: ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY
    Inventors: Paul S. Frenette, Sandra Pinho, Julie Lacombe
  • Publication number: 20150231165
    Abstract: Methods and devices are disclosed for treating or preventing infections in a subject due to Pseudomonas aeruginosa using coformycin analogs and inhibitors of Pseudomonas aeruginosa 5?-methylthioadenosine deaminase (MTADA).
    Type: Application
    Filed: September 10, 2013
    Publication date: August 20, 2015
    Applicants: ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY, Victoria Link Limited
    Inventors: Vern L. Schramm, Peter Charles Tyler, Richard Fröhlich
  • Publication number: 20150224188
    Abstract: Provided are compositions comprising a plurality of isolated mycobacterium membrane vesicles, and methods of use thereof, and methods of improving the efficacy of immunizations. Throughout this application various publications are referred to by number in parentheses. Full citations for the references may be found at the end of the specification. The disclosures of each of these publications, and also the disclosures of all patents, patent application publications and books recited herein, are hereby incorporated by reference in their entirety into the subject application to more fully describe the art to which the subject invention pertains.
    Type: Application
    Filed: September 23, 2013
    Publication date: August 13, 2015
    Applicant: ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY
    Inventors: Arturo Casadevall, Rafael Prados-Rosales, Steven A. Porcelli, William R. Jacobs