Abstract: Provided are peptides or mimetics that block corepressor binding to a BCL6 lateral groove. Also provided are methods or blocking corepressor binding to the BCL6 lateral groove. Additionally, methods of inhibiting BCL6 repression in a mammalian cell, and methods of treating a mammal with cancer are provided.
Type:
Grant
Filed:
February 23, 2011
Date of Patent:
April 22, 2014
Assignees:
Albert Einstein School of Medicine of Yeshiva University, Mount Sinai School of Medicine