Patents Assigned to ALBERT-LUDWIGS-UNIVERSITÄT FREIBURG
  • Publication number: 20240115139
    Abstract: A method for determining a concentration of a target gas in blood of a human or animal animate being. The method includes the steps of: generating electromagnetic excitation radiation having a carrier frequency, wherein the carrier frequency is selected such that the target gas and an absorbing gas absorb the excitation radiation, modulating an amplitude or the carrier frequency of the excitation radiation with a modulation frequency, illuminating an absorption path superficial to a skin of the animate being with the excitation radiation, generating a sound wave by an absorption of the excitation radiation in the absorption gas, and detecting at least one of an amplitude and a phase of the sound wave as a measure of a concentration of the target gas on the absorption path. Also provided is a photoacoustic sensor for determining a concentration of a target gas in blood of a human or animal animate being.
    Type: Application
    Filed: January 28, 2022
    Publication date: April 11, 2024
    Applicants: Albert-Ludwigs-Universität Freiburg, Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V.
    Inventors: Johannes KAPP, Katrin SCHMITT, Christian WEBER, Jürgen WÖLLENSTEIN, Hassan YASSINE
  • Patent number: 11949029
    Abstract: A transparent multi-layer assembly includes a transparent carrier structure comprising a polymer material and an electrically conductive transparent layer comprising an electrically conductive oxide. A silicon carbide layer is arranged as an adhesion promoter between the transparent carrier structure and the electrically conductive transparent layer.
    Type: Grant
    Filed: September 20, 2021
    Date of Patent: April 2, 2024
    Assignee: Albert-Ludwigs-Universität Freiburg
    Inventors: Max Eickenscheidt, Annette Mittnacht, Thomas Stieglitz, Marie T. Alt
  • Publication number: 20240060086
    Abstract: The present invention is directed to a kit of parts having biological activity, the kit of parts comprising a first target comprising a first protein and a second target comprising a second protein, wherein the first protein and the second protein are suitable to form a heterodimer upon irradiation with UV, visible or infrared light in a first wavelength range or in the dark, which can be reversed upon irradiating the heterodimer with UV, visible or infrared light in a second wavelength range or in the dark, wherein the second wavelength range is different from the first wavelength range, wherein the biological activity consists of triggering both the uptake of DNA, RNA, proteins, or small molecules into a cell which is preferably genetically unmodified, and biological effects, and characterized in that at least one of the first and the second target itself has reduced biological activity as compared with the heterodimer.
    Type: Application
    Filed: November 22, 2021
    Publication date: February 22, 2024
    Applicant: ALBERT-LUDWIGS-UNIVERSITÄT FREIBURG
    Inventors: Maximilian HÖRNER, Wilfried WEBER
  • Publication number: 20240051221
    Abstract: A process for producing articles with an extrusion-based additive manufacturing system using a consumable filament made from or containing a propylene polymer composition made from or containing: A) from 20% to 60% by weight of a heterophasic propylene copolymer; B) from 5% to 33% by weight of a propylene homopolymer or copolymer, wherein the copolymer contains up to 5% by weight of an alpha olefin; C) from 2% to 15% by weight of an elastomeric block copolymer made from or containing styrene; D) from 4% to 32% by weight of an elastomeric ethylene copolymer; E) from 5% to 50% by weight of a glass material as filler; and F) from 0.1% to 5% by weight of compatibilizer.
    Type: Application
    Filed: September 28, 2020
    Publication date: February 15, 2024
    Applicants: Basell Polyolefine GmbH, Albert-Ludwigs-Universität Freiburg
    Inventors: Carl Schirmeister, Karsten Schmitz, Yannic Kessler, Rainer Köhler, Erik Licht, Shahram Mihan, Jürgen Rohrmann, Dieter Langenfelder, Rolf Muelhaupt, Timo Hees
  • Publication number: 20240043819
    Abstract: The present invention relates to modified Cas9 nuclease comprising a substantial part of a Cas9 nuclease and fused thereto at least one substantial part of a dominant negative effector on non-homologous end-joining selected from the group consisting of RNF168, 53BP1, Ku80 and DNA-PK which compete with NHEJ promoting factors and CtIP.
    Type: Application
    Filed: July 26, 2021
    Publication date: February 8, 2024
    Applicant: Albert-Ludwigs-Universitaet Freiburg
    Inventors: Claudio MUSSOLINO, Toni CATHOMEN, Tatjana CORNU, Antonio CARUSILLO
  • Publication number: 20240036130
    Abstract: The present invention relates to a coil device for magnetic resonance imaging and/or magnetic resonance spectroscopy. The present invention further relates to a coil array of such coil devices. Moreover, the present invention relates to a power supply device for a coil device for magnetic resonance imaging and/or spectroscopy as well as to a signal receiving device for a coil device for magnetic resonance imaging and/or spectroscopy. Furthermore, the present invention relates to an apparatus for magnetic resonance imaging and/or magnetic resonance spectroscopy as well as to a method for performing magnetic resonance imaging and/or magnetic resonance spectroscopy.
    Type: Application
    Filed: December 8, 2021
    Publication date: February 1, 2024
    Applicant: Albert-Ludwigs-Universitaet Freiburg
    Inventors: Michael Bock, Ali Caglar Oezen
  • Publication number: 20230387339
    Abstract: A multiple solar cell having at least two partial cells, at least being formed from a direct semiconductor, having an upper partial cell facing the light and a lower partial cell facing away from the light, an upper bandgap of the upper partial cell being greater than a lower bandgap of the lower partial cell, and an intermediate layer arranged on the lower partial cell side facing away from the light. An optical element including a lower mirror element is arranged on the intermediate layer side facing away from the light, and has a partial element having structural elements arranged in a lateral direction on the intermediate layer side facing away from the light. The structural elements have a mean spacing less than or equal to 1.3 times a spacing value that results from a ratio of a wavelength of the lower bandgap to a refractive index of the lower partial cell or the lower mirror element has a roughness having a root-mean-square value of less than 50 nm.
    Type: Application
    Filed: October 1, 2021
    Publication date: November 30, 2023
    Applicants: Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V., Albert-Ludwigs-Universität Freiburg
    Inventors: David LACKNER, Oliver HÖHN, Benedikt BLÄSI, Jens OHLMANN, Frank DIMROTH, Jonas SCHÖN
  • Patent number: 11819681
    Abstract: An implantable electrode arrangement includes an electrically insulating carrier structure and an electrically conductive layer including an electrically conductive thin film layer. The electrically conductive thin film layer is structured to form at least one implantable electrode. The at least one implantable electrode has a local fractalization through a self-similar structuring chosen such that a mechanical resonance of the electrode in response to electric excitation with an excitation voltage is minimized.
    Type: Grant
    Filed: October 9, 2020
    Date of Patent: November 21, 2023
    Assignee: Albert-Ludwigs-Universität Freiburg
    Inventors: Jennifer Schulte, Thomas Stieglitz, Max Eickenscheidt
  • Patent number: 11785716
    Abstract: An implantable electrical connecting device includes a first elastic multi-ply layer and a second elastic multi-ply layer. The first elastic multi-ply layer has a first electrically conductive layer and a plurality of first electrical contacts electrically conductively connected to the first electrically conductive layer of the first elastic multi-ply layer. The second elastic multi-ply layer has a first electrically conductive layer and a plurality of second electrical contacts electrically conductively connected to the first electrically conductive layer of the second elastic multi-ply layer. The second electrical contacts make contact with the first electrical contacts.
    Type: Grant
    Filed: May 20, 2021
    Date of Patent: October 10, 2023
    Assignee: Albert-Ludwigs-Universität Freiburg
    Inventors: Patrick Kiele, Eva Singler, Thomas Stieglitz, Juan Sebastian Ordonez
  • Patent number: 11692869
    Abstract: A system comprising a first electroacoustic transducer connected to an interrogation unit and at least one second electroacoustic transducer connected to a resonator, wherein the first electroacoustic transducer and the second electroacoustic transducer form an acoustic channel and the second electroacoustic transducer forms with the resonator a passive cooperative target which, upon receiving an interrogation signal from the interrogation unit, transmits a response signal via the acoustic channel, and the interrogation signal has a higher energy than the response signal.
    Type: Grant
    Filed: August 12, 2018
    Date of Patent: July 4, 2023
    Assignee: Albert-Ludwigs-Universität Freiburg
    Inventors: Taimur Aftab, Joachim Hoppe, Di Shi, Dominik Jan Schott, Leonhard Michael Reindl
  • Publication number: 20230070126
    Abstract: The present invention relates to a chimeric antigen receptor comprising at least the following components: a) a peptidic structure capable of binding to a ligand; b) an extracellular spacing structure; c) a transmembrane domain; d) none or at least one co-stimulatory domain; and e) at least a TCR-derived activatory domain whereby a second TCR-derived activatory domain comprises the amino acid sequence RKGQRDLY (SEQ ID NO:1), which is capable to bind the lymphocyte specific Src kinase in a phosphorylation independent manner and its use in vectors for transducing T cells which are useful in the treatment of diseases, in particular tumors.
    Type: Application
    Filed: March 24, 2020
    Publication date: March 9, 2023
    Applicant: Albert-Ludwigs-Universitaet Freiburg
    Inventors: Wolfgang SCHAMEL, Susana MINGUET, Frederike HARTL
  • Publication number: 20230039030
    Abstract: The present invention relates to a novel chimeric antigen receptor (CAR) comprising an antigen-binding fragment which binds specifically to PSMA antigen, and a method of manufacturing high-quality CAR T cell products by transfection and/or transduction of T cells therewith, which allows to effectively treat tumors in vivo alone or in combination with pharmaceutical drugs, such chemotherapies, biopharmaceutical drugs, such as antibodies, or small-molecule drugs, such as protein kinase inhibitors.
    Type: Application
    Filed: December 14, 2020
    Publication date: February 9, 2023
    Applicant: Albert-Ludwigs-Universitaet Freiburg
    Inventors: Toni CATHOMEN, Philipp WOLF, Jamal ALZUBI, Susanne SCHULTZE-SEEMANN, Irina KUCKUCK
  • Publication number: 20220411756
    Abstract: The present invention discloses an extracellular matrix comprising a modified polysaccharide consisting of repeating disaccharide units whereby in at least 11% of the disaccharide units one primary alcohol group is oxidized into a carboxylic acid.
    Type: Application
    Filed: June 8, 2022
    Publication date: December 29, 2022
    Applicant: Albert-Ludwigs-Universität Freiburg
    Inventors: V. Prasad Shastri, Aurélien Forget
  • Patent number: 11513135
    Abstract: A method adapts a resonant frequency of a first filter of a closed control loop to a given frequency. The method includes feeding an output signal of a delta sigma modulator of the closed control loop into a frequency adaptation circuit and determining a first noise spectrum of the output signal in a first frequency band and a second noise spectrum of the output signal in a second frequency band. The first frequency band and the second frequency band are arranged symmetrically with respect to the given frequency. The method includes comparing the first noise spectrum with the second noise spectrum, generating an adaptation signal that causes a frequency adaptation of the resonant frequency if the first noise spectrum differs from the second noise spectrum, and outputting the adaptation signal from the frequency adaptation circuit to a control input of the first filter for adapting the resonant frequency.
    Type: Grant
    Filed: November 13, 2019
    Date of Patent: November 29, 2022
    Assignee: Albert-Ludwigs-Universität Freiburg
    Inventors: Maximilian Marx, Daniel De Dorigo, Yiannos Manoli, Xavier Cuignet
  • Publication number: 20220372064
    Abstract: The present invention concerns cobalamin derivatives of formula (I) wherein X is a ligand having a formula selected from among: —(CH2)1-5—S—(CH2)0-3—CH3, —S—(CH2)1-5—NH2 and further wherein R1 is H, methyl or ethyl, R2 is and R3 is —H or and its use in diseases caused by lack of vitamin B12 support.
    Type: Application
    Filed: June 3, 2022
    Publication date: November 24, 2022
    Applicant: Albert-Ludwigs-Universitaet Freiburg
    Inventor: Luciana HANNIBAL
  • Publication number: 20220325355
    Abstract: The invention relates to a method of diagnosing breast cancer and to the use of biomarkers for the detection and diagnosis of breast cancer.
    Type: Application
    Filed: August 7, 2020
    Publication date: October 13, 2022
    Applicant: Albert-Ludwigs-Universitaet Freiburg
    Inventors: Markus JAEGER, Marc HIRSCHFELD, Thalia ERBES, Daniela WEISS
  • Publication number: 20220259416
    Abstract: An extrusion additive manufacturing process including the step of extruding a polyethylene composition having a melt flow index MIE of at least 0.1 g/10 min., the composition made from or containing: A) from 1% to 40% by weight of a polyethylene component having a weight average molar mass Mw, as measured by GPC (Gel Permeation Chromatography), equal to or higher than 1,000,000 g/mol; B) from 1% to 95% by weight of a polyethylene component having a Mw value from 50,000 to 500,000 g/mol; and C) from 1% to 59% by weight of a polyethylene component having a Mw value equal to or lower than 5,000 g/mol.
    Type: Application
    Filed: February 12, 2020
    Publication date: August 18, 2022
    Applicants: Basell Polyolefine GmbH, Albert-Ludwigs-Universität Freiburg
    Inventors: Shahram Mihan, Erik Hans Licht, Rolf Mülhaupt, Carl Gunther Schirmeister, Timo Hees
  • Patent number: 11414761
    Abstract: At least one substrate part for is provided for coating. A first deposition is provided on the at least one support part as microstructuring of at least one first substance selected from the group consisting of rhenium, ruthenium, rhodium, palladium, silver, osmium, iridium, platinum, gold, tin, zinc, copper, cobalt, lead, nickel and alloys comprising these, from at least one first compound which provides the at least one first substance. A second deposition is provided on the at least one support part as a nano-structuring of at least one second substance chosen from a group comprising rhenium, ruthenium, rhodium, palladium, silver, osmium, iridium, platinum, gold and/or alloys thereof, of at least one second compound which provides the at least one second substance, in a solution.
    Type: Grant
    Filed: November 11, 2016
    Date of Patent: August 16, 2022
    Assignee: ALBERT-LUDWIGS-UNIVERSITÄT FREIBURG
    Inventors: Patrick Daubinger, Jochen Kieninger, Gerald Urban
  • Patent number: 11407978
    Abstract: The present invention discloses an extracellular matrix comprising a modified polysaccharide consisting of repeating disaccharide units whereby in at least 11% of the disaccharide units one primary alcohol group is oxidized into a carboxylic acid.
    Type: Grant
    Filed: August 18, 2011
    Date of Patent: August 9, 2022
    Assignee: Albert-Ludwigs-Universität Freiburg
    Inventors: V. Prasad Shastri, Aurelien Forget
  • Patent number: 11408953
    Abstract: Improvements in MR spiral imaging are provided in that spiral segments (2 to 8) are reordered, in particular alternately traversed and/or permuted. Moreover, repeatedly approaching the same post-trajectory points (16) between the acquisitions of the spiral segments (2 to 8) is provided, in which the post-trajectory points (16) are located outside of the center (18) of k-space (9), preferably outside of a region (20) of the k-space (9) covered by the spiral segments (2 to 8).
    Type: Grant
    Filed: February 5, 2020
    Date of Patent: August 9, 2022
    Assignee: Albert-Ludwigs-Universität Freiburg
    Inventors: Jurgen Hennig, Maxim Zaitsev