Abstract: An extrusion-based additive manufacturing process including the step of selectively depositing a molten thermoplastic material (P) on a film or sheet made from or containing a polymer blend obtained by melt blending a mixture made from or containing: (A) 60% to 98.8% by weight of a polyolefin; (B) 0.1% to 30% by weight of a compatibilizer; (C) 0.05% to 20% by weight of an amino resin; and (D) 0% to 5% by weight of an additive, wherein the amounts of (A), (B), (C) and (D) are based on the total weight of (A)+(B)+(C)+(D).

Abstract: An implantable electrical connector arrangement electrically connects a first electrical component and a second electrical component. The connector arrangement includes a first connector having a first terminal and a first coupling electrode connected to the first terminal and a second connector having a second terminal and a second coupling electrode connected to the second terminal. The first connector and the second connector are connectable to each other such that the first terminal and the second terminal are capacitively connectable via the first coupling electrode and the second coupling electrode in a connected state. A defined separation gap is formed between the first coupling electrode and the second coupling electrode in the connected state.

Abstract: The present invention relates to a biodegradable multilayer nanocapsule for the delivery of at least one biologically active agent into at least one target cell consisting of at least two layers of at least two biodegradable polymers which are laid one onto the other and whereby the biologically active agent is layered onto a layer of a biodegradable polymer and covered with a further layer of a biodegradable polymer, whereby one biologically active agent is a nucleic acid.

Abstract: A method for determining a concentration of a target gas in blood of a human or animal animate being. The method includes the steps of: generating electromagnetic excitation radiation having a carrier frequency, wherein the carrier frequency is selected such that the target gas and an absorbing gas absorb the excitation radiation, modulating an amplitude or the carrier frequency of the excitation radiation with a modulation frequency, illuminating an absorption path superficial to a skin of the animate being with the excitation radiation, generating a sound wave by an absorption of the excitation radiation in the absorption gas, and detecting at least one of an amplitude and a phase of the sound wave as a measure of a concentration of the target gas on the absorption path. Also provided is a photoacoustic sensor for determining a concentration of a target gas in blood of a human or animal animate being.

Abstract: A transparent multi-layer assembly includes a transparent carrier structure comprising a polymer material and an electrically conductive transparent layer comprising an electrically conductive oxide. A silicon carbide layer is arranged as an adhesion promoter between the transparent carrier structure and the electrically conductive transparent layer.

Abstract: The present invention is directed to a kit of parts having biological activity, the kit of parts comprising a first target comprising a first protein and a second target comprising a second protein, wherein the first protein and the second protein are suitable to form a heterodimer upon irradiation with UV, visible or infrared light in a first wavelength range or in the dark, which can be reversed upon irradiating the heterodimer with UV, visible or infrared light in a second wavelength range or in the dark, wherein the second wavelength range is different from the first wavelength range, wherein the biological activity consists of triggering both the uptake of DNA, RNA, proteins, or small molecules into a cell which is preferably genetically unmodified, and biological effects, and characterized in that at least one of the first and the second target itself has reduced biological activity as compared with the heterodimer.

Abstract: A process for producing articles with an extrusion-based additive manufacturing system using a consumable filament made from or containing a propylene polymer composition made from or containing: A) from 20% to 60% by weight of a heterophasic propylene copolymer; B) from 5% to 33% by weight of a propylene homopolymer or copolymer, wherein the copolymer contains up to 5% by weight of an alpha olefin; C) from 2% to 15% by weight of an elastomeric block copolymer made from or containing styrene; D) from 4% to 32% by weight of an elastomeric ethylene copolymer; E) from 5% to 50% by weight of a glass material as filler; and F) from 0.1% to 5% by weight of compatibilizer.

Abstract: The present invention relates to modified Cas9 nuclease comprising a substantial part of a Cas9 nuclease and fused thereto at least one substantial part of a dominant negative effector on non-homologous end-joining selected from the group consisting of RNF168, 53BP1, Ku80 and DNA-PK which compete with NHEJ promoting factors and CtIP.

Abstract: The present invention relates to a coil device for magnetic resonance imaging and/or magnetic resonance spectroscopy. The present invention further relates to a coil array of such coil devices. Moreover, the present invention relates to a power supply device for a coil device for magnetic resonance imaging and/or spectroscopy as well as to a signal receiving device for a coil device for magnetic resonance imaging and/or spectroscopy. Furthermore, the present invention relates to an apparatus for magnetic resonance imaging and/or magnetic resonance spectroscopy as well as to a method for performing magnetic resonance imaging and/or magnetic resonance spectroscopy.

Abstract: A multiple solar cell having at least two partial cells, at least being formed from a direct semiconductor, having an upper partial cell facing the light and a lower partial cell facing away from the light, an upper bandgap of the upper partial cell being greater than a lower bandgap of the lower partial cell, and an intermediate layer arranged on the lower partial cell side facing away from the light. An optical element including a lower mirror element is arranged on the intermediate layer side facing away from the light, and has a partial element having structural elements arranged in a lateral direction on the intermediate layer side facing away from the light. The structural elements have a mean spacing less than or equal to 1.3 times a spacing value that results from a ratio of a wavelength of the lower bandgap to a refractive index of the lower partial cell or the lower mirror element has a roughness having a root-mean-square value of less than 50 nm.

Abstract: An implantable electrode arrangement includes an electrically insulating carrier structure and an electrically conductive layer including an electrically conductive thin film layer. The electrically conductive thin film layer is structured to form at least one implantable electrode. The at least one implantable electrode has a local fractalization through a self-similar structuring chosen such that a mechanical resonance of the electrode in response to electric excitation with an excitation voltage is minimized.

Abstract: An implantable electrical connecting device includes a first elastic multi-ply layer and a second elastic multi-ply layer. The first elastic multi-ply layer has a first electrically conductive layer and a plurality of first electrical contacts electrically conductively connected to the first electrically conductive layer of the first elastic multi-ply layer. The second elastic multi-ply layer has a first electrically conductive layer and a plurality of second electrical contacts electrically conductively connected to the first electrically conductive layer of the second elastic multi-ply layer. The second electrical contacts make contact with the first electrical contacts.

Abstract: A system comprising a first electroacoustic transducer connected to an interrogation unit and at least one second electroacoustic transducer connected to a resonator, wherein the first electroacoustic transducer and the second electroacoustic transducer form an acoustic channel and the second electroacoustic transducer forms with the resonator a passive cooperative target which, upon receiving an interrogation signal from the interrogation unit, transmits a response signal via the acoustic channel, and the interrogation signal has a higher energy than the response signal.

Abstract: The present invention relates to a chimeric antigen receptor comprising at least the following components: a) a peptidic structure capable of binding to a ligand; b) an extracellular spacing structure; c) a transmembrane domain; d) none or at least one co-stimulatory domain; and e) at least a TCR-derived activatory domain whereby a second TCR-derived activatory domain comprises the amino acid sequence RKGQRDLY (SEQ ID NO:1), which is capable to bind the lymphocyte specific Src kinase in a phosphorylation independent manner and its use in vectors for transducing T cells which are useful in the treatment of diseases, in particular tumors.

Abstract: The present invention relates to a novel chimeric antigen receptor (CAR) comprising an antigen-binding fragment which binds specifically to PSMA antigen, and a method of manufacturing high-quality CAR T cell products by transfection and/or transduction of T cells therewith, which allows to effectively treat tumors in vivo alone or in combination with pharmaceutical drugs, such chemotherapies, biopharmaceutical drugs, such as antibodies, or small-molecule drugs, such as protein kinase inhibitors.

Abstract: The present invention discloses an extracellular matrix comprising a modified polysaccharide consisting of repeating disaccharide units whereby in at least 11% of the disaccharide units one primary alcohol group is oxidized into a carboxylic acid.

Abstract: A method adapts a resonant frequency of a first filter of a closed control loop to a given frequency. The method includes feeding an output signal of a delta sigma modulator of the closed control loop into a frequency adaptation circuit and determining a first noise spectrum of the output signal in a first frequency band and a second noise spectrum of the output signal in a second frequency band. The first frequency band and the second frequency band are arranged symmetrically with respect to the given frequency. The method includes comparing the first noise spectrum with the second noise spectrum, generating an adaptation signal that causes a frequency adaptation of the resonant frequency if the first noise spectrum differs from the second noise spectrum, and outputting the adaptation signal from the frequency adaptation circuit to a control input of the first filter for adapting the resonant frequency.

Abstract: The present invention concerns cobalamin derivatives of formula (I) wherein X is a ligand having a formula selected from among: —(CH2)1-5—S—(CH2)0-3—CH3, —S—(CH2)1-5—NH2 and further wherein R1 is H, methyl or ethyl, R2 is and R3 is —H or and its use in diseases caused by lack of vitamin B12 support.

Abstract: The invention relates to a method of diagnosing breast cancer and to the use of biomarkers for the detection and diagnosis of breast cancer.

Abstract: An extrusion additive manufacturing process including the step of extruding a polyethylene composition having a melt flow index MIE of at least 0.1 g/10 min., the composition made from or containing: A) from 1% to 40% by weight of a polyethylene component having a weight average molar mass Mw, as measured by GPC (Gel Permeation Chromatography), equal to or higher than 1,000,000 g/mol; B) from 1% to 95% by weight of a polyethylene component having a Mw value from 50,000 to 500,000 g/mol; and C) from 1% to 59% by weight of a polyethylene component having a Mw value equal to or lower than 5,000 g/mol.