Patents Assigned to Albert-Ludwigs-Universitaet Freiburg
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Patent number: 12292491Abstract: The present invention relates to a coil device for magnetic resonance imaging and/or magnetic resonance spectroscopy. The present invention further relates to a coil array of such coil devices. Moreover, the present invention relates to a power supply device for a coil device for magnetic resonance imaging and/or spectroscopy as well as to a signal receiving device for a coil device for magnetic resonance imaging and/or spectroscopy. Furthermore, the present invention relates to an apparatus for magnetic resonance imaging and/or magnetic resonance spectroscopy as well as to a method for performing magnetic resonance imaging and/or magnetic resonance spectroscopy.Type: GrantFiled: December 8, 2021Date of Patent: May 6, 2025Assignee: Albert-Ludwigs-Universitaet FreiburgInventors: Michael Bock, Ali Caglar Oezen
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Publication number: 20250128055Abstract: Provided is a method of treating a psychiatric disorder and/or blood pressure disorder in a subject in need thereof. The method includes implanting one or more leads into the subject, wherein each of the one or more leads comprises a plurality of electrodes; generating an electrical signal; generating an electrical field that is substantially directional and substantially focused; and delivering the electrical field to a superolateral branch in a medial forebrain bundle of the subject via at least one of the plurality of electrodes. Provided are also an implantable pulse generator configured to deliver the corresponding electrical field via respective leads and electrodes.Type: ApplicationFiled: October 7, 2022Publication date: April 24, 2025Applicant: Albert Ludwigs Universität FreiburgInventors: Volker Coenen, Thomas Schläpfer
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Publication number: 20250101258Abstract: The present invention relates to compositions comprising modified lignin and modified cellulose which are suitable for use in additive manufacturing (e.g. 3D printing), in particular for direct ink writing (DIW). In particular, the invention relates to a composition suitable for direct ink writing, comprising a) a functional ether of lignin, b) a functional ether of cellulose, and c) a solvent comprising an aliphatic alcohol and optionally water. The content of the functional ether of lignin in the composition is at least 25 wt. % based on the combined weights of functional ether of lignin and functional ether of cellulose.Type: ApplicationFiled: October 17, 2022Publication date: March 27, 2025Applicant: Albert-Ludwigs-Universität FreiburgInventors: Marie-Pierre LABORIE, Lisa-Sophie BILLHARZ, Wolfgang GLASSER
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Patent number: 12257767Abstract: A process for producing articles with an extrusion-based additive manufacturing system using a consumable filament made from or containing a propylene polymer composition made from or containing: A) from 20% to 60% by weight of a heterophasic propylene copolymer; B) from 5% to 33% by weight of a propylene homopolymer or copolymer, wherein the copolymer contains up to 5% by weight of an alpha olefin; C) from 2% to 15% by weight of an elastomeric block copolymer made from or containing styrene; D) from 4% to 32% by weight of an elastomeric ethylene copolymer; E) from 5% to 50% by weight of a glass material as filler; and F) from 0.1% to 5% by weight of compatibilizer.Type: GrantFiled: September 28, 2020Date of Patent: March 25, 2025Assignees: Basell Polyolefine GmbH, Albert-Ludwigs-Universität FreiburgInventors: Carl Schirmeister, Karsten Schmitz, Yannic Kessler, Rainer Köhler, Erik Licht, Shahram Mihan, Jürgen Rohrmann, Dieter Langenfelder, Rolf Muelhaupt, Timo Hees
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Publication number: 20250092395Abstract: The present invention relates to the use of a GluN2D inhibitor or a mGluR2 inhibitor in the treatment or relapse prevention of a depressive episode. Vectors encoding some of these inhibitors are also provided for use in the relapse prevention or treatment of depressive episodes. Also provided are pharmaceutical compositions comprising these inhibitors, preferably for use in the relapse prevention or treatment of a depressive episode.Type: ApplicationFiled: January 25, 2023Publication date: March 20, 2025Applicant: ALBERT-LUDWIGS-UNIVERSITÄT FREIBURGInventors: Claus NORMANN, Stefan VESTRING
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Publication number: 20250073702Abstract: A device for particle isolation includes a reservoir to contain a liquid including particles and a channel with an inlet and an outlet. The inlet is configured to be fluidically coupled to the reservoir containing the liquid including particles. The device includes further a pressure generator configured to generate a pressure gradient in the channel by which liquid including a single particle is aspirated from the reservoir through the inlet of the channel against the force of gravity and to cause liquid to be output through the outlet of the channel. Additionally, the device includes an actuator configured to cause a relative movement between the particles and the inlet of the channel so as to bring a single particle in a vicinity of the inlet to be aspirated through the inlet.Type: ApplicationFiled: November 20, 2024Publication date: March 6, 2025Applicants: Albert-Ludwigs-Universität Freiburg, Hahn-Schickard-Gesellschaft für angewandte Forschung e.V.Inventors: Viktoria ZIEGER, Sabrina KARTMANN, Daniel FREJEK
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Therapeutic methods involving modulating inflammasome activation of myeloid-derived suppressor cells
Patent number: 12234480Abstract: In one aspect, a method of treating a subject having or at risk of having graft-versus-host disease (GvHD) generally includes administering to the subject a plurality of myeloid-derived suppressor cells (MDSCs) effective to ameliorate at least one symptom or clinical sign of graft-versus-host disease compared to a suitable control subject. In another aspect, a method of treating a tumor in a subject generally includes administering to the subject an anti-tumor therapy and co-administering to the subject an inflammasome inciting agent in an amount effective to increase inflammasome activation of MDSCs sufficiently to reduce suppressor function of the MDSCs.Type: GrantFiled: December 11, 2020Date of Patent: February 25, 2025Assignees: Regents of the University of Minnesota, The University of North Carolina at Chapel Hill, Albert-Ludwigs-Universität Freiburg, St. Jude Children's Research Hospital, Inc.Inventors: Bruce R. Blazar, Brent Koehn, Peter J. Murray, Jenny P. Y. Ting, Robert Zeiser, Jeff S. Miller -
Publication number: 20250011483Abstract: A polyolefin composition (I) made from or containing: (A) 15-80% by weight of a heterophasic polymer composition made from or containing: (a) 50-80% by weight of a propylene polymer, and (b) 20-50% by weight of a copolymer of ethylene and an alpha-olefin; and (B) 20-85% by weight of a polyethylene composition made from or containing: (i) 25-85% by weight of a polyethylene component, having a weight average molecular weight Mw(i), equal to or higher than 1,000,000 g/mol; and (ii) 10-65% by weight of a polyethylene component, having an Mw(ii) equal to or lower than 5,000 g/mol, wherein the polyethylene composition (B) is made from or containing at least 70% by weight of (i)+(ii).Type: ApplicationFiled: October 10, 2022Publication date: January 9, 2025Applicants: Basell Polyolefine GMBH, Albert-Ludwigs-Universität FreiburgInventors: Carl Gunther Schirmeister, Erik Hans Licht, Timo Hees, Jürgen Rohrmann, Rainer Köhler, Shahram Mihan, Yannic Kessler, Rolf Muelhaupt
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Patent number: 12187877Abstract: An extrusion additive manufacturing process including the step of extruding a polyethylene composition having a melt flow index MIE of at least 0.1 g/10 min., the composition made from or containing: A) from 1% to 40% by weight of a polyethylene component having a weight average molar mass Mw, as measured by GPC (Gel Permeation Chromatography), equal to or higher than 1,000,000 g/mol; B) from 1% to 95% by weight of a polyethylene component having a Mw value from 50,000 to 500,000 g/mol; and C) from 1% to 59% by weight of a polyethylene component having a Mw value equal to or lower than 5,000 g/mol.Type: GrantFiled: February 12, 2020Date of Patent: January 7, 2025Assignees: Basell Polyolefine GmbH, Albert-Ludwigs-Universität FreiburgInventors: Shahram Mihan, Erik Hans Licht, Rolf Mülhaupt, Carl Gunther Schirmeister, Timo Hees
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Patent number: 12160557Abstract: A method for simulating, at an instant, the illumination of an indoor scene observed by a camera and being illuminated by outdoor light, the method comprising: a first preliminary phase including: obtaining a reflectance map of the scene elaborating normalized radiosity maps for the contribution of the sky and the ground, a second phase carried out within a first given duration from the instant including: obtaining the position of the sun, obtaining a normalized radiosity map for the contribution of the sun, a third phase, including: acquiring an image of the scene, determining brightness scale parameters for the ground, the sky, and the sun. The disclosure also proposes tracking the camera position.Type: GrantFiled: February 24, 2022Date of Patent: December 3, 2024Assignees: TOYOTA JIDOSHA KABUSHIKI KAISHA, ALBERT-LUDWIGS-UNIVERSITAET FREIBURGInventors: Jugesh Sundram, Mark Van Loock, Michael Krawez, Tim Caselitz, Wolfram Burgard
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Publication number: 20240392174Abstract: A process for the manufacture of a non-isocyanate polyurethane (NIPU) composition by transesterification of a condensed tannin with a carbonate or a carbonate precursor followed by the reaction with a hardener selected from diamines, triamines, polyamines and mixtures thereof and products and compositions obtained thereby.Type: ApplicationFiled: September 23, 2022Publication date: November 28, 2024Applicant: Albert-Ludwigs-Universität FreiburgInventors: Marie-Pierre LABORIE, Gopakumar SIVASANKARAPILLAI, Antonio PIZZI
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Patent number: 12153206Abstract: The formation of compensation elements (7) on an at least partially transparent membrane (2) that provides the actuator elements (5) to compensate or neutralize unwanted deformations of the compartment (3), e.g. induced by gravity effects, and/or to generate positive (convex) deflections of a limiting membrane (14), where the plurality of actuator elements (5) and the at least one compensation element (7) are provided at a common electrode membrane (2).Type: GrantFiled: February 3, 2020Date of Patent: November 26, 2024Assignee: Albert-Ludwigs-Universität FreiburgInventors: Caglar Ataman, Kaustubh Banerjee, Pouya Rajaeipour, Hans Zappe
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Patent number: 12117509Abstract: A magnetic field probe (1) having a capsule (3), in which an MR-active substance (5) is encapsulated. Two coils (7, 9) are preferably arranged in the capsule (3). Advantageous production methods for magnetic field probes (1) are also described, as well as advantageous uses of the magnetic field probe (1) and methods in which magnetic field probes (1) of this kind and arrangements of magnetic field probes (1) are used.Type: GrantFiled: April 2, 2020Date of Patent: October 15, 2024Assignee: Albert-Ludwigs Universität FreiburgInventors: Niklas Wehkamp, Maxim Zaitsev, Philipp Rovedo
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Patent number: 12092534Abstract: In an embodiment a tactile sensor includes a plurality of stress sensors and at least one contact body, wherein the stress sensors are configured to detect a load pattern applied on a detection surface of the contact body.Type: GrantFiled: June 22, 2020Date of Patent: September 17, 2024Assignee: Albert-Ludwigs-Universitaet FreiburgInventors: Jan Kollmitz, Matthias Kuhl, Yiannos Manoli
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Publication number: 20240274435Abstract: A semiconductor layer and a method and an apparatus for its manufacturing are disclosed. The semiconductor layer includes at least one compound of the formula M1aM21-aN, where M1 is selected from group 13 of the periodic table and M2 is selected from the group including scandium, yttrium, erbium, and europium and where the parameter a is selected between 0.01 and 0.99. The method includes supplying a first precursor into a reaction chamber, the first precursor including at least M2 and being supplied to the reaction chamber at a molar flow rate of at least 1·10?6 mol/min by providing the first precursor by means of a first bubbler from which it is evaporated and supplied to the reaction chamber, the temperature of the first bubbler being more than 90° C.Type: ApplicationFiled: April 4, 2024Publication date: August 15, 2024Applicants: Albert-Ludwigs-Universität Freiburg, Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V.Inventors: Stefano LEONE, Christian MANZ, Hanspeter MENNER, Joachim WIEGERT, Jana LIGL
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Publication number: 20240227311Abstract: An extrusion-based additive manufacturing process including the step of selectively depositing a molten thermoplastic material (P) on a film or sheet made from or containing a polymer blend obtained by melt blending a mixture made from or containing: (A) 60% to 98.8% by weight of a polyolefin; (B) 0.1% to 30% by weight of a compatibilizer; (C) 0.05% to 20% by weight of an amino resin; and (D) 0% to 5% by weight of an additive, wherein the amounts of (A), (B), (C) and (D) are based on the total weight of (A)+(B)+(C)+(D).Type: ApplicationFiled: January 26, 2022Publication date: July 11, 2024Applicants: Basell Polyolefine GmbH, Albert-Ludwigs-Universität FreiburgInventors: Carl Gunther Schirmeister, Erik Hans Licht, Karsten Schmitz, Yannic Kessler, Klaus Klemm, Jürgen Rohrmann, Dieter Langenfelder, Mikhail Dureev, Rolf Muelhaupt, Mirco Müller, Steer Peter, Kolano Benjamin
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Patent number: 11996287Abstract: A semiconductor layer and a method and an apparatus for its manufacturing are disclosed. The semiconductor layer includes at least one compound of the formula M1aM21-aN, where M1 is selected from group 13 of the periodic table and M2 is selected from the group comprising scandium, yttrium, erbium, and europium and where the parameter a is selected between 0.01 and 0.99. The method includes supplying a first precursor into a reaction chamber, the first precursor including at least M2 and being supplied to the reaction chamber at a molar flow rate of at least 1·10?6 mol/min by providing the first precursor by means of a first bubbler from which it is evaporated and supplied to the reaction chamber, the temperature of the first bubbler being more than 90° C.Type: GrantFiled: August 27, 2020Date of Patent: May 28, 2024Assignees: Albert-Ludwigs-Universität Freiburg, Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V.Inventors: Stefano Leone, Christian Manz, Hanspeter Menner, Joachim Wiegert, Jana Ligl
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Patent number: 11986304Abstract: A sensor array includes a base for providing a probe signal and a plurality of modular recording sites. Each modular recording site of the plurality of modular recording sites is configured for receiving a signal, for converting the signal into a digital sensor signal and to provide the digital sensor signal to the base. The base is configured for receiving a plurality of digital sensor signals from the plurality of modular recording sites and to process the plurality of digital sensor signals so as to provide the probe signal.Type: GrantFiled: August 6, 2020Date of Patent: May 21, 2024Assignee: ALBERT-LUDWIGS-UNIVERSITÄT FREIBURGInventors: Yiannos Manoli, Daniel De Dorigo, Christian Moranz, Hagen Graf
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Publication number: 20240131802Abstract: An extrusion-based additive manufacturing process including the step of selectively depositing a molten thermoplastic material (P) on a film or sheet made from or containing a polymer blend obtained by melt blending a mixture made from or containing: (A) 60% to 98.8% by weight of a polyolefin; (B) 0.1% to 30% by weight of a compatibilizer; (C) 0.05% to 20% by weight of an amino resin; and (D) 0% to 5% by weight of an additive, wherein the amounts of (A), (B), (C) and (D) are based on the total weight of (A)+(B)+(C)+(D).Type: ApplicationFiled: January 26, 2022Publication date: April 25, 2024Applicants: Basell Polyolefine GmbH, Albert-Ludwigs-Universität FreiburgInventors: Carl Gunther Schirmeister, Erik Hans Licht, Karsten Schmitz, Yannic Kessler, Klaus Klemm, Jürgen Rohrmann, Dieter Langenfelder, Mikhail Dureev, Rolf Muelhaupt, Mirco Müller, Steer Peter, Kolano Benjamin
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Patent number: 11957918Abstract: An implantable electrical connector arrangement electrically connects a first electrical component and a second electrical component. The connector arrangement includes a first connector having a first terminal and a first coupling electrode connected to the first terminal and a second connector having a second terminal and a second coupling electrode connected to the second terminal. The first connector and the second connector are connectable to each other such that the first terminal and the second terminal are capacitively connectable via the first coupling electrode and the second coupling electrode in a connected state. A defined separation gap is formed between the first coupling electrode and the second coupling electrode in the connected state.Type: GrantFiled: May 18, 2021Date of Patent: April 16, 2024Assignee: Albert-Ludwigs-Universität FreiburgInventors: Patrick Kiele, Cristian Pasluosta, Thomas Stieglitz