Patents Assigned to Albert P. Halluin
  • Plasminogen activator-heparin conjugates
    Patent number: 5023078
    Abstract: A pharmaceutical composition is prepared wherein a biologically active conjugated plasminogen activator is selectively conjugated to at least one heparin fragment having a terminal 2,5-anhydro-D-mannose residue which has an aldehyde not involved in intramolecular hemiacetal formation. The resulting conjugate has a prolonged half-life as compared to native tissue plasminogen activator and is able to deliver heparin to the site of clot dissolution to prevent reocclusion.
    Type: Grant
    Filed: May 24, 1989
    Date of Patent: June 11, 1991
    Assignee: Albert P. Halluin
    Inventor: Albert P. Halluin