Abstract: A novel process for obtaining an .alpha.-amino-nitrile of the formula ##STR1## by reacting a nitrile with a metallic reducing agent to form a metallic imine of the formula ##STR2## and reacting the latter with a cyaniding agent to obtain the corresponding .alpha.-amino-nitrile.

Abstract: The present invention relates to the synthesis of nitriles having an amine function on the adjacent carbon.

Abstract: 2,2-Bisphenoxy-dimethyl-aminoethane to improve brain disfunction.

Abstract: This invention relates to novel aroylated derivatives of pyrrole. More particularly it provides the novel naphthoyl derivatives of pyrrolyl-2-carboxylic acid having the general formula I: ##STR1## wherein: R.sub.1 is a lower alkyl radical, a phenyl radical or a hydrogen;X is a hydrogen, a hydroxy or a methylsulphinyl group;Y is a hydrogen or together with A' a double bond;A is a hydrogen or a hydroxy;A' is a hydrogen or together with Y a double bond;B is a hydrogen or a hydroxy;B' is a hydrogen or together with C a double bond;C is a hydrogen or together with B' a double bond;C' is a hydrogen, a hydroxy or a methylsulphinyl group;with the proviso that X, Y, A, A', B, B', C and C' are not simultaneously a hydrogen.The compounds according to this invention, may exist in the free acid form or as a salt.They found a use in human or veterinary medicine in the form of pharmaceutical compositions for preventing or treating the immunological diseases.

Abstract: This invention relates to novel pharmaceutical compositions having immuno-suppressive activities, the active ingredient of which is a 4-aroyl N-alkyl or aryl pyrrolyl-2 carboxylic acid or a salt thereof.The pharmaceutical compositions have therapeutic utility for treating auto-immune diseases, or in the prevention of rejection of graft organs.

Abstract: This invention relates to compounds having the formula: ##STR1## which represents the isomer Z, the isomer E or the mixture of both stereoisomers of the oximino group and in which:A represents O or S,X.sup.1 represents a halogen atom, a hydrogen atom or a methyl group,R represents a hydrogen atom or a C.sub.1-5 alkyl group,X.sup.2 and X.sup.3, which may be the same or different, represent each a hydrogen atom, a halogen atom or a C.sub.1-5 alkyl group, andR' represents a hydrogen atom or a C.sub.1-5 alkyl group, andthe group ##STR2## is at 2- or 3-position on the heterocycle, and the salts of acids of the formula (I) with physiologically acceptable bases, and the compounds which are metabolically converted to compounds of the formula (I).Said compounds are therapeutically useful, typically as hypocholesterolemic, hypolipemic and uricosuric agents.

Abstract: The present invention relates to a method of lowering the concentration of plasma triglycerides of a subject in need thereof, which comprises administering an effective but non toxic amount of each isomer or a mixture thereof of compound ##STR1## or pharmaceutically acceptable addition salt of said amine formed with an acid.

Abstract: The invention provides water-soluble salts of tienilic acid, 2,3-dichloro-4-(2-thienylcarbonyl)-phenoxyacetic acid, and amino acids of the formula ##STR1## in which n is an integer of 1 to 5 and R represents a basic nitrogenous group, preferably an amino group or guanidino group. These salts, unlike the parent acid are water-soluble and are of good biodisponibility and may be used in injectable form, e.g. for emergency treatment.

Abstract: The present invention relates to compounds having the formula: ##STR1## in which n is an integer from 1 to 4, A is selected from the group consisting of oxygen and sulfur and R.sub.1 and R.sub.2 are independently selected from the group consisting of hydrogen and C.sub.1-4 alkyl.These compounds are useful for the preparation of corresponding amino derivatives.

Abstract: Aromatic compounds having the following formula are disclosed: ##STR1## in which, A in the heterocyclic group is selected from the group of O and S;R.sub.1, R.sub.2, R.sub.3 and R.sub.4, which may be identical or different, are selected from the group consisting of hydrogen, halogen, lower alkyl, lower alkoxy;R.sub.5 is selected from the group consisting of hydrogen, lower alkyl and nitro;n is an integer from 1 to 3 andR.sub.6 and R.sub.7 together with the nitrogen atom to which they are attached form a 5- to 7-membered N-heterocyclic saturated group which optionally contain a second hetero atom, which may be O or N and pharmaceutically acceptable acid addition salts of the amino group thereof, said compound being in the form of the E isomer of the oximino group, the Z isomer or mixtures thereof.These novel compounds exhibit a coronary vasodilatory activity and may be used in the treatment of cardiopathies.A method of treating such disorders and a composition useful for treating same are also disclosed.

Abstract: Compounds of the general formula I ##STR1## wherein n represents 0, 1 or 2, A represents oxygen or sulphur, Z represents oxygen or hydroxyimino, X represents hydrogen, or halogen, the dotted lines represent bonds which may be unsaturated or saturated, R.sub.1 and R.sub.2 each represent hydrogen or alkyl, and R.sub.3 represents hydrogen, halogen or methyl, and R.sub.4 represents a hydrogen atom, or R.sub.3 and R.sub.4 together with the two carbon atoms to which they are attached represent benzene, and their pharmaceutically acceptable salts are useful in therapy, in particular as uricosuric agents or as diuretic and uricosuric agents.

Abstract: The present invention relates to a compound selected from the compounds of the formula: ##STR1## in which: R.sup.1 is selected from hydrogen and C.sub.1-4 alkyl,R is selected from C.sub.1-6 alkyl, benzyl and phenyl,Ar is selected from phenyl, phenyl monosubstituted with a group selected from C.sub.1-4 alkyl, C.sub.1-4 alkoxy and halogen, phenyl polysubstituted with groups selected from C.sub.1-4 alkyl, C.sub.1-4 alkoxy and halogen, naphthyl, naphthyl monosubstituted with a group selected from C.sub.1-4 alkyl, C.sub.1-4 alkoxy and halogen, naphthyl polysubstituted with groups selected from C.sub.1-4 alkyl, C.sub.1-4 alkoxy and halogen, thienyl, furyl and pyrrolyland > Z represents a carbonyl group, a group of the formula >C.dbd.NOH or an alcoholic group >CHOHand the salts of acids of formula (I) with physiologically acceptable bases. Said compounds are useful for the treatment of hyperuricemia.

Abstract: Compounds of the formula I ##STR1## in which R.sub.1 and R.sub.2 each represent a hydrogen atom, a halogen atom, an alkyl group containing 1 to 3 carbon atoms, an alkoxy group containing 1 to 3 carbon atoms or a trifluoromethyl group; and R.sub.3 represents an alkyl group containing 1 to 4 carbon atoms mono- or polyhydroxyl substituted, the alcohol functions being unesterified or esterified by benzoic acid are useful as in therapy as medicaments, in particular as psychotropic and anorexigenic agents.

Abstract: Therapeutic compositions, particularly for treating intestinal disorders, and a method of treating colopathics by administering an effective amount of the compositions are described. The compositions contain a therapeutically effective amount of at least one isomer of the oximino group of the compound having the formula: ##STR1## in which: R is selected from the group consisting of halogen atoms and lower alkoxy groups;n is an integer 2 or 3, andZ.sub.1 and Z.sub.2 are the same or different lower alkyl groups, orNZ.sub.1 Z.sub.2 represents a saturated heterocyclic group which may have a second heteroatom selected from the group consisting of N and O,and the addition salts of the amino group with pharmaceutically acceptable acids,with a physiological acceptable excipient.

Abstract: Bis (2-phenoxyalkane carboxylic acids) and their esters and salts, as well as a method for their preparation. These compounds are useful for the treatment of hyperlipemia and arteriosclerosis.

Abstract: The present invention relates to a method of treating chronic or non-chronic respiratory disorders, consisting in administering to the patient by the oral, rectal or parenteral route, a medicament for dilating the bronchi, comprising as active ingredient at least one compound of formula I or one of its pharmaceutically acceptable salts: ##STR1## in which A represents O or S, R.sub.1, R.sub.2, R.sub.3, R.sub.4 represent the hydrogen atom, an atom of halogen, an alkyl group with 1 to 4 carbon atoms or an alkoxy or alkenyloxy group,Z.sub.1 and Z.sub.2 represent an alkyl group or form with the nitrogen atom to which they are attached a saturated heterocyclic compound such as, in particular, pyrrolidine, piperidine, morpholine.

Abstract: New method for the remedial or prophylactic treatment of drepanocytosis and related syndromes, comprising administering BETA-DIMETHYLAMINO ETHYL ESTER OF PARACHLOROPHENOXY ACETIC ACID or one of its physiologically acceptable acid addition salts, by the IM or oral route.