Abstract: The present invention relates to a class of morphinan compounds and quaternary ammonium salts thereof, substituted in Position 14, which may be used as highly active analgesics or also as opioid antagonists. The present invention also relates to the pharmaceutically acceptable salts and easily produced derivatives thereof, a process for the production thereof and use thereof in the production of pharmaceutical specialities.
Type:
Grant
Filed:
September 6, 2007
Date of Patent:
February 2, 2010
Assignee:
Alcasynn Pharmaceuticals GmbH
Inventors:
Helmut Schmidhammer, Mariana Spetea, Johannes Schutz, Elisabeth Greiner, Falko Schüllner, Bettina Sailer, Kurt Stübegger
Abstract: This invention relates to a class of 6-amino-morphinan compounds of formula (I) which can be used as highly active analgesics. This invention also relates to their pharmaceutically acceptable salts and easily accessible derivatives (e.g. esters or amides of the amino acid derivatives), to a process for their manufacture and their application in the manufacture of pharmaceutical specialties.