Abstract: Provided is a compound and so on having aldehyde dehydrogenase 2 (ALDH2) activation effect. A compound, a pharmaceutically acceptable salt of the compound, or a prodrug of the compound or the salt, the compound being represented by the following formula (1): wherein A is a heterocycle, R1 and R2 are each independently hydrogen, an alkyl, an alkenyl, or an alkynyl. R3 is an alkyl, ac alkenyl, or as alkynyl, and X1 and X2 are each independently a halogen.

Abstract: An object of the present invention is to provide a compound having CK1? inhibition activity and/or ALK5 inhibition activity and the like. The object thereof can be attained by a compound represented by the following formula (1): wherein R1 to R10 each independently represent hydrogen, alkyl, cycloalkyl, or a halogen, wherein R2 and R3 or R4 and R5 together with two carbon atoms to which they are attached form a 5-membered ring containing one heteroatom selected from the group consisting of an oxygen atom, a nitrogen atom, and a sulfur atom, optionally substituted with alkyl; or a pharmaceutically acceptable salt thereof, wherein the compound excludes 2-[4-(2,3-dihydro-5-benzofuranyl)-2-(1,1-dimethylethyl)-1H-imidazol-5-yl]-6-methylpyridine.