Patents Assigned to Alchemia
  • Patent number: 10087136
    Abstract: Object of the invention is a process for the preparation of Metaraminol and the salts thereof, in particular its pharmaceutically acceptable salts, especially Metaraminol bi-L-tartrate. Object of the invention is also the use of a novel catalyst and a novel ligand for the synthesis of Metaraminol and its salts.
    Type: Grant
    Filed: January 25, 2017
    Date of Patent: October 2, 2018
    Assignee: LABORATORI ALCHEMIA S.R.L.
    Inventors: Davide Brenna, Andrea Marchesi, Voichita Mihali
  • Patent number: 9066919
    Abstract: This application provides methods and compositions for the treatment of cancer. The application provides compositions including hyaluronic acid and a chemotherapeutic agent such as irinotecan that are useful in the treatment of cancer.
    Type: Grant
    Filed: August 5, 2005
    Date of Patent: June 30, 2015
    Assignee: Alchemia Oncology Pty Limited
    Inventor: Tracey J. Brown
  • Patent number: 8937052
    Abstract: The present invention relates generally to the field of therapeutics and in particular, chemotherapy. Even more particularly, the present invention provides therapeutic strategies which reduce the toxicity or enhance the efficacy of chemotherapeutic agents. Compositions and methods of treatment and prophylaxis are also contemplated by the present invention.
    Type: Grant
    Filed: July 27, 2006
    Date of Patent: January 20, 2015
    Assignee: Alchemia Oncology Pty Limited
    Inventor: Tracey J. Brown
  • Publication number: 20150005485
    Abstract: Preparation and use of synthetic monosaccharides, disaccharides, trisaccharides, tetrasaccharides and pentasaccharides useful for the preparation of synthetic heparinoids.
    Type: Application
    Filed: January 29, 2014
    Publication date: January 1, 2015
    Applicant: ALCHEMIA LIMITED
    Inventors: Joachim SEIFERT, Latika SINGH, Tracie E. RAMSDALE, Michael L. WEST, Nicholas B. DRINNAN
  • Publication number: 20140328828
    Abstract: The present invention relates generally to treatment and prophylactic protocols for cellular disease or disorders, such as diseases and disorders associated with abnormal cellular proliferation. More particularly, the present invention provides uses of compositions comprising therapeutic antibodies and hyaluronan in the treatment or prophylaxis of cellular diseases and disorders.
    Type: Application
    Filed: December 4, 2013
    Publication date: November 6, 2014
    Applicant: ALCHEMIA ONCOLOGY PTY LIMITED
    Inventors: Tracey J. BROWN, Gary R. BROWNLEE
  • Patent number: 8741970
    Abstract: The present invention relates to the enhancement of the efficacy of drugs, and more particularly, with overcoming the resistance of cells or organisms to drugs. In particular, the present invention provides a method for enhancing the effectiveness of a cytotoxic or anti-neoplastic agent, comprising the step of co-administering said agent with hyaluronan, wherein co-administration with hyaluronan enhances the agent's cancer cell-killing potential.
    Type: Grant
    Filed: December 14, 2011
    Date of Patent: June 3, 2014
    Assignee: Alchemia Oncology Pty Limited
    Inventor: Tracey J. Brown
  • Patent number: 8686131
    Abstract: Preparation and use of synthetic trisaccharides useful for the preparation of synthetic heparinoids.
    Type: Grant
    Filed: December 14, 2011
    Date of Patent: April 1, 2014
    Assignee: Alchemia Limited
    Inventors: Joachim Seifert, Latika Singh, Tracie E. Ramsdale, Michael L. West, Nicholas B. Drinnan
  • Patent number: 8673586
    Abstract: A method of inhibiting or effecting the activity of protein kinase activity which comprises contacting a protein kinase with a compound of formula (I) being a derivative of a furanose or pyranose form of a monosaccharide, or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: May 1, 2012
    Date of Patent: March 18, 2014
    Assignee: Alchemia Limited
    Inventors: Wim Meutermans, Karl Schafer, Michael L. West, Craig Muldoon, Fiona Foley, Natalie Bouloc, Gerald Tometzki
  • Patent number: 8623354
    Abstract: The present invention relates generally to treatment and prophylactic protocols for cellular diseases or disorders, such as diseases and disorders associated with abnormal cellular proliferation. More particularly, the present invention provides compositions comprising therapeutic antibodies and hyaluronan and their use in the treatment or prophylaxis of cellular diseases and disorders.
    Type: Grant
    Filed: September 4, 2006
    Date of Patent: January 7, 2014
    Assignee: Alchemia Oncology Pty Limited
    Inventors: Tracey J. Brown, Gary R. Brownlee
  • Publication number: 20130197103
    Abstract: The present invention relates to the enhancement of the efficacy of drugs, and more particularly, with overcoming the resistance of cells or organisms to drugs. In particular, the present invention provides a method for enhancing the effectiveness of a cytotoxic or anti-neoplastic agent, comprising the step of co-administering said agent with hyaluronan, wherein co-administration with hyaluronan enhances the agent's cancer cell-killing potential.
    Type: Application
    Filed: December 14, 2011
    Publication date: August 1, 2013
    Applicant: Alchemia Oncology Pty Limited
    Inventor: Tracey J. BROWN
  • Publication number: 20130172210
    Abstract: The invention provides a method of identifying biologically active compounds comprising: (a) designing a first library of compounds of formula (1) to scan molecular diversity wherein each compound of the library has at least two pharmacophoric groups R1 to R5 as defined below and wherein compound of the library has same number of pharmacophoric groups; (b) assaying the first library of compounds in one or more biological assay(s); and (c) designing a second library wherein each compound of the second library contains one or more additional pharmacophoric group with respect to the first library; such that the/each component of the first and second library is a compound of formula (1).
    Type: Application
    Filed: February 20, 2013
    Publication date: July 4, 2013
    Applicant: ALCHEMIA LIMITED
    Inventor: Alchemia Limited
  • Patent number: 8460658
    Abstract: The present invention relates generally to the modulation of hyaluronan (HA) synthesis and degradation. The present invention further contemplates modulation of cellular proliferation, useful in the prophylaxis and/or treatment of inflammatory disorders including hyperproliferative conditions, such as but not limited to, cancer and psoriasis. The present invention is directed to compounds, agents, pharmaceutically active agents, medicaments, therapeutics, actives, drugs and the like which specifically target a portion of HAS which is accessible to the extracellular environment in malignant or inflammatory or proliferative cells but which portion is not accessible to the external environment in “normal” cells. A “normal” cell in this instance is a non-malignant, inflammatory or proliferative cell.
    Type: Grant
    Filed: June 13, 2011
    Date of Patent: June 11, 2013
    Assignee: Alchemia Oncology Pty Limited
    Inventors: Tracey J. Brown, Gary R. Brownlee
  • Patent number: 8426345
    Abstract: The invention provides a method of identifying biologically active compounds comprising: (a) designing a first library of compounds of formula (1) to scan molecular diversity wherein each compound of the library has at least two pharmacophoric groups R1 to R5 as defined below and wherein compound of the library has same number of pharmacophoric groups; (b) assaying the first library of compounds in one or more biological assay(s); and (c) designing a second library wherein each compound of the second library contains one or more additional pharmacophoric group with respect to the first library; such that the/each component of the first and second library is a compound of formula (1).
    Type: Grant
    Filed: October 3, 2006
    Date of Patent: April 23, 2013
    Assignee: Alchemia Limited
    Inventors: Wim Meutermans, Johannes Zuegg, Michael L. West
  • Patent number: 8404833
    Abstract: Preparation and use of synthetic disaccharides useful for the preparation of synthetic heparinoids.
    Type: Grant
    Filed: December 14, 2011
    Date of Patent: March 26, 2013
    Assignee: Alchemia Limited
    Inventors: Joachim Seifert, Latika Singh, Tracie E. Ramsdale, Michael L. West, Nicholas B. Drinnan
  • Patent number: 8388993
    Abstract: The present invention relates to the enhancement of bioavailability of chemotherapeutic agents for the treatment of disease. In particular, the present invention relates to a method of enhancing the bioavailability of a chemotherapeutic agent comprising the step of administering to a subject in need thereof a therapeutically effective amount of hyaluronan.
    Type: Grant
    Filed: May 1, 2006
    Date of Patent: March 5, 2013
    Assignee: Alchemia Oncology Pty Limited
    Inventor: Tracey J. Brown
  • Publication number: 20130011852
    Abstract: A method of inhibiting or effecting the activity of protein kinase activity which comprises contacting a protein kinase with a compound of formula (I) being a derivative of a furanose or pyranose form of a monosaccharide, or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: May 1, 2012
    Publication date: January 10, 2013
    Applicant: Alchemia Limited
    Inventors: Wim Meutermans, Karl Schafer, Michael L. West, Craig Muldoon, Fiona Foley, Natalie Bouloc, Gerald Tometzki
  • Patent number: 8287894
    Abstract: This application provides methods and compositions for the treatment of cancer. The application provides compositions comprising hyaluronic acid and a chemotherapeutic agent such as irinotecan that are useful in the treatment of cancer.
    Type: Grant
    Filed: July 27, 2005
    Date of Patent: October 16, 2012
    Assignee: Alchemia Oncology Pty Limited
    Inventors: Tracey J. Brown, Richard M. Fox
  • Publication number: 20120220759
    Abstract: Preparation and use of synthetic monosaccharides, disaccharides, trisaccharides, tetrasaccharides and pentasaccharides for use in the preparation of synthetic heparinoids.
    Type: Application
    Filed: December 14, 2011
    Publication date: August 30, 2012
    Applicant: Alchemia Limited
    Inventors: Joachim SEIFERT, Latika SINGH, Tracie Elizabeth RAMSDALE, Michael Leo WEST, Nicholas Barry DRINNAN
  • Publication number: 20120208993
    Abstract: Preparation and use of synthetic trisaccharides useful for the preparation of synthetic heparinoids.
    Type: Application
    Filed: December 14, 2011
    Publication date: August 16, 2012
    Applicant: Alchemia Limited
    Inventors: Joachim SEIFERT, Latika SINGH, Tracie Elizabeth RAMSDALE, Michael Leo WEST, Nicholas Barry DRINNAN
  • Patent number: 8222381
    Abstract: New compounds and methods for the preparation of combinatorial libraries of potentially biologically active compounds are based on monosaccharides of formula I being a derivative of a furanose or pyranose form of a monosaccharide, .
    Type: Grant
    Filed: August 8, 2003
    Date of Patent: July 17, 2012
    Assignee: Alchemia Limited
    Inventors: Michael West, Peter Andrews, Tracie Elizabeth Ramsdale, Wim Meutermans, Giang Thanh Le, Chris Clark, Giovanni Abbenante, Ligong Liu