Patents Assigned to Alchemia Limited
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Publication number: 20150005485Abstract: Preparation and use of synthetic monosaccharides, disaccharides, trisaccharides, tetrasaccharides and pentasaccharides useful for the preparation of synthetic heparinoids.Type: ApplicationFiled: January 29, 2014Publication date: January 1, 2015Applicant: ALCHEMIA LIMITEDInventors: Joachim SEIFERT, Latika SINGH, Tracie E. RAMSDALE, Michael L. WEST, Nicholas B. DRINNAN
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Patent number: 8686131Abstract: Preparation and use of synthetic trisaccharides useful for the preparation of synthetic heparinoids.Type: GrantFiled: December 14, 2011Date of Patent: April 1, 2014Assignee: Alchemia LimitedInventors: Joachim Seifert, Latika Singh, Tracie E. Ramsdale, Michael L. West, Nicholas B. Drinnan
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Patent number: 8673586Abstract: A method of inhibiting or effecting the activity of protein kinase activity which comprises contacting a protein kinase with a compound of formula (I) being a derivative of a furanose or pyranose form of a monosaccharide, or a pharmaceutically acceptable salt thereof.Type: GrantFiled: May 1, 2012Date of Patent: March 18, 2014Assignee: Alchemia LimitedInventors: Wim Meutermans, Karl Schafer, Michael L. West, Craig Muldoon, Fiona Foley, Natalie Bouloc, Gerald Tometzki
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Publication number: 20130172210Abstract: The invention provides a method of identifying biologically active compounds comprising: (a) designing a first library of compounds of formula (1) to scan molecular diversity wherein each compound of the library has at least two pharmacophoric groups R1 to R5 as defined below and wherein compound of the library has same number of pharmacophoric groups; (b) assaying the first library of compounds in one or more biological assay(s); and (c) designing a second library wherein each compound of the second library contains one or more additional pharmacophoric group with respect to the first library; such that the/each component of the first and second library is a compound of formula (1).Type: ApplicationFiled: February 20, 2013Publication date: July 4, 2013Applicant: ALCHEMIA LIMITEDInventor: Alchemia Limited
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Patent number: 8426345Abstract: The invention provides a method of identifying biologically active compounds comprising: (a) designing a first library of compounds of formula (1) to scan molecular diversity wherein each compound of the library has at least two pharmacophoric groups R1 to R5 as defined below and wherein compound of the library has same number of pharmacophoric groups; (b) assaying the first library of compounds in one or more biological assay(s); and (c) designing a second library wherein each compound of the second library contains one or more additional pharmacophoric group with respect to the first library; such that the/each component of the first and second library is a compound of formula (1).Type: GrantFiled: October 3, 2006Date of Patent: April 23, 2013Assignee: Alchemia LimitedInventors: Wim Meutermans, Johannes Zuegg, Michael L. West
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Patent number: 8404833Abstract: Preparation and use of synthetic disaccharides useful for the preparation of synthetic heparinoids.Type: GrantFiled: December 14, 2011Date of Patent: March 26, 2013Assignee: Alchemia LimitedInventors: Joachim Seifert, Latika Singh, Tracie E. Ramsdale, Michael L. West, Nicholas B. Drinnan
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Publication number: 20130011852Abstract: A method of inhibiting or effecting the activity of protein kinase activity which comprises contacting a protein kinase with a compound of formula (I) being a derivative of a furanose or pyranose form of a monosaccharide, or a pharmaceutically acceptable salt thereof.Type: ApplicationFiled: May 1, 2012Publication date: January 10, 2013Applicant: Alchemia LimitedInventors: Wim Meutermans, Karl Schafer, Michael L. West, Craig Muldoon, Fiona Foley, Natalie Bouloc, Gerald Tometzki
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Publication number: 20120220759Abstract: Preparation and use of synthetic monosaccharides, disaccharides, trisaccharides, tetrasaccharides and pentasaccharides for use in the preparation of synthetic heparinoids.Type: ApplicationFiled: December 14, 2011Publication date: August 30, 2012Applicant: Alchemia LimitedInventors: Joachim SEIFERT, Latika SINGH, Tracie Elizabeth RAMSDALE, Michael Leo WEST, Nicholas Barry DRINNAN
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Publication number: 20120208993Abstract: Preparation and use of synthetic trisaccharides useful for the preparation of synthetic heparinoids.Type: ApplicationFiled: December 14, 2011Publication date: August 16, 2012Applicant: Alchemia LimitedInventors: Joachim SEIFERT, Latika SINGH, Tracie Elizabeth RAMSDALE, Michael Leo WEST, Nicholas Barry DRINNAN
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Patent number: 8222381Abstract: New compounds and methods for the preparation of combinatorial libraries of potentially biologically active compounds are based on monosaccharides of formula I being a derivative of a furanose or pyranose form of a monosaccharide, .Type: GrantFiled: August 8, 2003Date of Patent: July 17, 2012Assignee: Alchemia LimitedInventors: Michael West, Peter Andrews, Tracie Elizabeth Ramsdale, Wim Meutermans, Giang Thanh Le, Chris Clark, Giovanni Abbenante, Ligong Liu
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Patent number: 8114970Abstract: Preparation of synthetic monosaccharides, for use in the preparation of synthetic heparinoids.Type: GrantFiled: January 15, 2009Date of Patent: February 14, 2012Assignee: Alchemia LimitedInventors: Joachim Seifert, Latika Singh, Tracie E. Ramsdale, Michael L. West, Nicholas B. Drinnan
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Publication number: 20110201794Abstract: Methods are described for the preparation of combinatorial libraries of potentially biologically active disaccharide compounds. These compounds are variously functionalized, with a view to varying lipid solubility size, function an other properties, with the particular aim of discovering novel drug or drug-like compounds, or compounds with useful properties. The invention provides intermediates, processes and synthetic strategies for the solution or solid phase synthesis of disaccharides, variously functionalized about the sugar ring, including the addition of aromaticity and charge, and the placement of pharmaceutically useful groups and isosteres.Type: ApplicationFiled: December 17, 2010Publication date: August 18, 2011Applicant: Alchemia LimitedInventors: Wim Meutermans, Michael L. West, George Adamson, Giang Thanh Le, Nicholas B. Drinnan, Giovani Abbenante, Bernd Becker, Matthias Grathwohl, Premraj Rajaratnam, Gerald Tometzki
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Patent number: 7994140Abstract: The present invention relates to a method of identifying a candidate therapeutic agent. The method comprises contacting a G-Protein Coupled Receptor (GPCR) with a compound of General Formula (I), or a pharmaceutically acceptable salt thereof determining whether the compound inhibits or effects signal transduction activity of the GPCR, wherein a compound that inhibits or effects the activity of the GPCR is a candidate therapeutic agent.Type: GrantFiled: October 10, 2003Date of Patent: August 9, 2011Assignee: Alchemia LimitedInventors: Wim Meutermans, Glang Le Thanh, Giovanni Abbenante, Gerald Tometzki, Judy Halliday, Johannes Zuegg
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Patent number: 7989422Abstract: The present invention, in one aspect, provides a method of inhibiting bacterial growth by contacting bacteria with an effective amount of at least one monosaccharide compound of formula (1) as described herein:Type: GrantFiled: December 20, 2006Date of Patent: August 2, 2011Assignee: Alchemia LimitedInventors: Wim Meutermans, Declan McKeveney, Johannes Zuegg, Rajaratnam Premraj, Craig Muldoon, Giang Thanh Le
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Publication number: 20110165700Abstract: A method of inhibiting or effecting the activity of an integrin receptor comprises contacting an integrin with a pyranose of formula I, or a pharmaceutically acceptable salt thereof.Type: ApplicationFiled: March 14, 2011Publication date: July 7, 2011Applicant: Alchemia LimitedInventors: Wim MEUTERMANS, Michael L. West, Giang Thanh Le, Judy Halliday, Christopher Clark
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Patent number: 7875707Abstract: Methods are described for the preparation of combinatorial libraries of potentially biologically active disaccharide compounds. These compounds are variously functionalized, with a view to varying lipid solubility size, function an other properties, with the particular aim of discovering novel drug or drug-like compounds, or compounds with useful properties. The invention provides intermediates, processes and synthetic strategies for the solution or solid phase synthesis of disaccharides, variously functionalized about the sugar ring, including the addition of aromaticity and charge, and the placement of pharmaceutically useful groups and isosteres.Type: GrantFiled: April 24, 2003Date of Patent: January 25, 2011Assignee: Alchemia LimitedInventors: Wim Meutermans, Michael West, George Adamson, Giang Thanh Le, Nicholas B. Drinnan, Giovanni Abbenante, Bernd Becker, Matthias Grathwohl, Premraj Rajaratnam, Gerald Tometzki
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Patent number: 7737287Abstract: This invention relates to combinatorial libraries of potentially biologically active mainly monosaccharide compounds and to methods of preparing same. These compounds are variously functionalized, with a view to varying lipid solubility, size, function and other properties, with the particular aim of discovering a drug or drug-like compound, or compounds with useful properties. The invention provides intermediates, processes and synthetic strategies for the solution or solid phase synthesis of monosaccharides, variously functionalized about the sugar ring, including the addition of aromaticity and charge, and the placement of amino acid and peptide side chain units of isosteres thereof.Type: GrantFiled: March 28, 2003Date of Patent: June 15, 2010Assignee: Alchemia LimitedInventors: Wim Meutermans, Michael Leo West, Thanh Le Giang, George Adamson, Karl Schafer, Giovanni Abbenante
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Patent number: 7700577Abstract: A method of inhibiting bacterial growth by contacting a bacteria with at least one disaccharide compound of General Formula I,Type: GrantFiled: October 16, 2003Date of Patent: April 20, 2010Assignee: Alchemia LimitedInventors: Wim Meutermans, Giang Le Thanh, Giovani Abbenante, Gerald Tometzki, George Adamson, Bernd Becker, Matthias Grathwohl, Premraj Rajaratnam
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Publication number: 20090187013Abstract: Preparation of synthetic monosaccharides, disaccharides, trisaccharides, tetrasaccharides and pentasaccharides for use in the preparation of synthetic heparinoids.Type: ApplicationFiled: January 15, 2009Publication date: July 23, 2009Applicant: Alchemia LimitedInventors: Joachim SEIFERT, Latika Singh, Tracie Elizabeth Ramsdale, Michael Leo West, Nicholas Barry Drinnan
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Publication number: 20090163373Abstract: The invention provides a method of identifying biologically active compounds comprising: (a) designing a first library of compounds of formula (1) to scan molecular diversity wherein each compound of the library has at least two pharmacophoric groups R1 to R5 as defined below and wherein compound of the library has same number of pharmacophoric groups; (b) assaying the first library of compounds in one or more biological assay(s); and (c) designing a second library wherein each compound of the second library contains one or more additional pharmacophoric group with respect to the first library; such that the/each component of the first and second library is a compound of formula (1).Type: ApplicationFiled: October 3, 2006Publication date: June 25, 2009Applicant: Alchemia LimitedInventors: Gerald B. Tometzki, Michael L. West, Wim Meutermans, Johannes Zuegg