Abstract: A method of controlling anterior segment ocular bleeding is described. The method utilizes various clonidine derivatives (e.g., p-aminoclonidine) as the hemostatic agent.

Abstract: Xanthine derivatives are described which decrease the stinging associated with the application of ophthalmic acidic anti-inflammatory agents.

Abstract: A hand-held cannula assembly for irrigating and aspirating ophthalmic surgical sites includes an irrigation cannula circumscribed about an aspiration cannula and extending out through the forward end of the assembly from a reservoir for the irrigation fluid in the handle. Pressurized irrigation fluid is supplied to the reservoir through the rearward end of the handle and flows through openings in the irrigation cannula periphery into an annular flow passage between the two cannulas. An opening in the irrigation cannula issues the irrigation fluid at the surgical site. Aspiration fluid is drawn into the aspiration cannula which extends through the handle interior to an outflow opening at the rearward handle end.

Abstract: A tissue irrigating solution useful for irrigating animal tissue, such as ocular tissue and neuro tissue, during surgery, contains sodium, potassium, magnesium, calcium, chloride, and bicarbonate ions as well as dextrose and glutathione in proportions consistant with the osmotic stability and continued metabolism of the tissue cells. The irrigating solution is prepared by mixing a first basic solution which provides the bicarbonate and a second acidic solution which provides the calcium, magnesium, dextrose and glutathione. The first and second solutions may be stored as stable, sterile solutions for extended periods of time and mixed within 24 hours of use.

Abstract: The improved polymeric hydrogel suitable for use in forming soft contact lenses is described. The hydrogel is improved by means of its resistance to the formation of calcium, lipid and protein deposits thereon. This resistance is achieved by means of covalent modification of the hydrogel with a surfactant.

Abstract: Inhibition of aldose reductase activity with tetracyclic spiro-hydantoins, new tetracyclic spirohydantoin derivatives useful in the treatment of complications arising from diabetes mellitus, and a process for preparing spiro-imidazolidine-diones by reacting a mono- or di-fluorofluorene with an excess of oxygen and a tetralkyl- or arylalkyl-trialkyl-ammonium hydroxide are disclosed.

Abstract: Disclosed are substituted or unsubstituted planar tricyclic fluorene or nuclear analogs thereof, spiro-coupled to a five-membered ring containing a secondary amide, and the pharmaceutically acceptable salts thereof. These compounds are useful, inter alia, in the treatment of diabetes. Also disclosed are processes for the preparation of such compounds; pharmaceutical compositions comprising such compounds; and methods of treatment comprising administering such compounds and compositions when indicated for, inter alia, long term, prophylactic treatment of the diabetes syndrome.

Abstract: This invention relates to ophthalmic compositions which comprise quaternary ammonium salt having the formula ##STR1## wherein X=a pharmaceutically acceptable anion, such compositions providing aqueous disinfecting solutions for contact lenses as well as a preserved ocular compositions including contact lens treating solutions comfort drop solutions, preserved saline solutions, ointments and other ocular medicaments.

Abstract: 2-(Trisubstituted phenylimino)-imidazole compounds also known as 2-(trisubstituted anilino)-1,3 diazacyclopentene-(2) compounds are used to lower intraocular pressure.

Abstract: Anti-acne preparations include finely divided, dispersed particles of benzoyl peroxide and finely divided, dispersed particles of salicylic acid in an aqueous gel formed from carboxy vinyl polymer resins. The gels are prepared without loss of salicylic acid by fully hydrating the resin in an aqueous medium and allowing the resin to gel in the absence of an alkaline neutralizing agent.

Abstract: Soft and hard contact lenses are freed from deposits by rubbing them with a particulate organic polymer with a carrier, the polymer having a particular size in the range from about one micron to about 600 microns and a Rockwell hardness in the range of from about R120 to about M68, or a shore hardness in the range from about A15 to about D100.

Abstract: 6-Methythio and 6-methylsulfinyl spiro-chroman-imidazolidine diones useful in the treatment of complications arising from diabetes mellitus.

Abstract: 2-Trisubstituted Phenylimino-imidazolines also known as 2-(trisubstituted anilino)-1,3 diazacyclopentene-(2) compounds and their use for lowering intraocular pressure are disclosed.

Abstract: An ophthalmic irrigating solution useful for irrigating the human eye contains sodium, potassium, magnesium, calcium, chloride, and bicarbonate ions as well as dextrose and glutathione in proportions consistent with the osmotic stability and continued metabolism of the endothelial cells. The irrigating solution is prepared by mixing a first basic solution which provides the bicarbonate and a second acidic solution which provides the calcium, magnesium, dextrose and glutathione. The first and second solutions may be stored as stable, sterile solutions for extended periods of time and mixed within 24 hours of use.

Abstract: Tetracyclic spiro-hydantoin derivatives useful in the treatment of complications arising from diabetes mellitus.

Abstract: Inhibition of aldose reductase activity with tetracyclic spiro-hydantoins.

Abstract: This invention relates to polymeric alcohols and polymeric ethers including poly(ethylene glycol), polyethylene oxide and polyethylene glycol methyl ether as prophylactic agents against soilant deposits on contact lenses.

Abstract: This invention relates to the quaternary ammonium salt, .alpha.-4-[-tris (2-hydroxyethyl) ammonium chloride-2-butenyl] poly[1-dimethyl ammonium chloride-2-butenyl]-w-tris (2-hydroxyethyl) ammonium chloride, providing aqueous disinfecting solutions for contact lenses as well as a preservative for ocular solutions including contact lens treating solutions.

Abstract: The present invention is directed to an aqueous dispersion of an ophthalmic drug and a high molecular weight polymer which forms a highly viscous gel and can be used to prolong the duration of activity of the ophthalmic drug when the gel is applied into the conjunctival sac of the eye. The ophthalmic drug-containing gel composition has prolonged retention time in the eye and remains in contact with the surface of the eye for an extended period of time.

Abstract: A contact lens bathing case, in which a pair of contact lenses is sealed with a cleaning and disinfectant solution, and a heating unit, for receiving and heating the filled case therein, cooperate to eliminate leakage problems, i.e. loss of solution, associated with improperly closed contact lens cases. The heating case includes a heating element and a movable lens case holder which is movable from an open position remote from the heating element to a closed position adjacent to the heating element whereat the solution and lenses may be heated. Closure prevention means prevent the holder which has received an improperly closed case from being moved to the closed position.