Abstract: Vitreoretinal instruments and methods related thereto are disclosed herein. The disclosure describes various example vitreoretinal instruments having various aspirating port configurations. A vitreoretinal instrument may include a handle and a cannula coupled to the handle. The cannula may include a straight portion and a curved portion. The curved portion may be configurable between a straight configuration and a curved configuration. The curved configuration may include a first curved portion having a curvature defined by a first radius. The curved configuration may include a second curved portion having a curvature defined by a second radius different from the first radius. The curved portion may further include one or more ports formed in the curved portion.

Abstract: System and method for imaging a target site with a housing assembly having a head unit configured to be at least partially directed towards the target site. An optical coherence tomography (OCT) module and stereoscopic visualization camera are at least partially located in the head unit and configured to obtain a first set and a second of volumetric data of the target site, respectively. A controller is configured to register the first set of volumetric data with the second set of volumetric data to create a third set of registered volumetric data. The third set of registered volumetric data and second set of volumetric data are rendered, via a volumetric render module, to a first and second region. The first region and the second region are overlaid to obtain a composite shared view of the target.

Abstract: A system for guiding an ophthalmic procedure is disclosed. The system includes a housing assembly with a head unit configured to be at least partially directed towards a target site in an eye. An optical coherence tomography (OCT) module and stereoscopic visualization camera are at least partially located in the head unit and configured to obtain a first set and a second set of volumetric data, respectively. A controller is configured to register the first set and second set of volumetric data to create a third set of registered volumetric data. The third set and second set of registered volumetric data are rendered, via a volumetric render module, to a first and second region. The first region and the second region are overlaid to obtain a shared composite view of the target site. The controller is configured to extract structural features and/or enable visualization of the target site.

Abstract: The invention is related to a process for producing contact lenses that not only comprise a water gradient structural configurations, but also have a minimized uptakes of polyquaternium-1 and a long-lasting surface hydrophilicity and wettability even after being undergone a 30-days lens care regime.

Abstract: The invention is related to a process for producing contact lenses that not only comprise a water gradient structural configurations, but also have a minimized uptakes of polyquaternium-1 and a long-lasting surface hydrophilicity and wettability even after being undergone a simulated 30-days lens care regime.

Abstract: Vitrectomy probes and methods related thereto are disclosed herein. The disclosure describes various example vitrectomy probes having a rotational helical cutter. An example helical cutter includes an outer cutter portion and an inner cutter portion received therewithin. The inner cutter portion is operable to rotationally reciprocate within the outer cutter portion about a longitudinal axis thereof. A helical shearing surface formed at a distal end of the inner cutter portion is operable to sever material entering the cutter via a port formed in the outer cutter portion.

Abstract: Pixelated array optics for mode mixing may be used to homogenize different modes in an optical fiber used for surgical illumination. A pixelated phase array, such as a digital micromirror device or an LCD phase plate, may impart motion to an incident beam entering the optical fiber to generate a homogeneous illumination field from a coherent light source.

Abstract: A calibration method for a camera-based measuring device comprises positioning a calibration object simulating an anterior region of the eye on a holder arranged movably in a first direction relative to a camera of the measuring device within a view field of the camera. The first direction is toward and away from the camera substantially along a camera axis. A motorized drive unit, in drive connection with the holder, is firstly controlled to drive the holder, with the calibration object positioned thereon in the camera view field, relative to the camera along the first direction at least once past a position of maximum definition of an image of the calibration object taken by the camera. A ratio between an actual size and an imaging size of the calibration object is determined on the basis of a camera image of the calibration object taken at the position of maximum definition.

Abstract: The present disclosure provides a system and method for cutting a flap in laser ophthalmic surgery using polarization sensitive optical coherence tomography (PS-OCT). The system includes a PS-OCT system, a femtosecond laser, control device, and processor. The PS-OCT system includes a PS-OCT source, a polarization component, a reference reflector, a beam splitter, a wave plate, and a detector. The processor receives data relating to an interference pattern of a reflected PS-OCT beam, received at the detector, determines a relative fiber orientation of the sample, determines whether a photodisruption pattern generated by the femtosecond laser to cut the flap should be adjusted horizontally or vertically, based on the relative fiber orientation, and may generate a control signal to adjust the photodisruption pattern generated by the femtosecond laser. The disclosure further provides a method for cutting a flap on an eye using PS-OCT.

Abstract: A multifocal ophthalmic lens includes an ophthalmic lens and a diffractive element. The ophthalmic lens has a base curvature corresponding to a base power. The diffractive element produces constructive interference in at least four consecutive diffractive orders corresponding a range of vision between near and distance vision. The constructive interference produces a near focus, a distance focus corresponding to the base power of the ophthalmic lens, and an intermediate focus between the near focus and the distance focus.

Abstract: The invention is related to a method for producing silicone hydrogel contact lenses with having a stable coating thereon. A method of the invention comprises a water-based coating process (step) for forming a relatively-stable base coating of a homo- or copolymer of acrylic acid or C1-C3 alkylacrylic acid onto a silicone hydrogel contact lens made from a lens formulation comprising from about 35% to about 60% by weight of N-vinylpyrrolidone.

Abstract: Disclosed herein is an implantable accommodative IOL system for insertion into an eye of a patient, the system comprising: an optical element and a housing including an opaque frame. The optical element comprises an optical lens having variable optical power, and the opaque frame is circumferentially disposed around a periphery of the optical element.

Abstract: A multifocal ophthalmic lens includes an ophthalmic lens and a diffractive element. The ophthalmic lens has a base curvature corresponding to a base power. The diffractive element produces constructive interference in at least four consecutive diffractive orders corresponding a range of vision between near and distance vision. The constructive interference produces a near focus, a distance focus corresponding to the base power of the ophthalmic lens, and an intermediate focus between the near focus and the distance focus. A diffraction efficiency of at least one of the diffractive orders is suppressed to less than ten percent.

Abstract: An ophthalmic lens includes an optic comprising an anterior surface, a posterior surface, and an optical axis. At least one of the anterior surface and the posterior surface has a surface profile including a base curvature, a refractive region having the base curvature, and a diffractive region comprising a diffractive profile including a plurality of diffractive steps. At least a portion of the diffractive profile constitutes a combination of a base diffractive profile defining multiple foci for the ophthalmic lens and an achromatizing structure that reduces longitudinal chromatic aberrations.

Abstract: The invention is generally related to a process for producing a relatively high molecular weight poly(methacrylic acid) (“PMAA”) in a water-based system. The process of the invention comprises polymerization of from about 1% to about 20% by weight of methacrylic acid in water or a water-based system in the presence of thiol compound and an azo radical initiator under controlled reaction and process conditions. A process of the invention can be easily scaled up into the pilot scale for producing large quantities of high molecular weight PMAAs. The invention is also related to high molecular weight poly(methacrylic acid)s obtained according to a process of the invention.

Abstract: The invention is related to a method for producing silicone medical devices, in particular, silicone contact lenses, having consistent mechanical properties in a cost-effective manner. The invention is also related to a silicone medical device, especially a soft silicone contact lens.

Abstract: OCT-enabled injection for vitreoretinal surgery may involve using an OCT image to detect when a surgical injector penetrates a desired tissue layer of the eye for receiving an injection. The injection may be triggered or automatically actuated based on the detection of the surgical injector from the OCT image.

Abstract: A method of manufacturing of an astigmatic contact lens having a toric portion and a ballast portion such that said ballast portion causes the toric portion of the contact lens to properly orient in the eye of the wearer. The toric lenses are manufactured by an effective process control method for cylinder axis angle in toric lens production by modifying the target cylinder angle for mold rotation by eliminating the accumulative cylinder axis error from all previous steps including tool making, tool assembly, and molding. The amount modifying the target angle is determined by accurately determine the true cylinder axis on the corresponding mold by using a high-resolution interferometer, such as FISBA FS10M or equivalent models from Trioptics ?Shape® vertical series.

Abstract: A method of manufacturing a colored contact lens including the steps of providing a transparent contact lens having a pupil section and an iris section, the iris section surrounding the pupil section and applying a colorant to the surface of the contact lens. The colorant is applied to the contact lens as an amorphous pattern and covers an effective amount of the iris section of the same. The amorphous pattern provides a lens capable of changing the apparent color of the iris of a person wearing the lens while imparting a very natural appearance.

Abstract: A method and system provide a multifocal ophthalmic device. The ophthalmic lens has an anterior surface, a posterior surface and at least one diffractive structure including a plurality of echelettes. The echelettes have at least one step height of at least one wavelength and not more than two wavelengths in optical path length. The diffractive structure(s) reside on at least one of the anterior surface and the posterior surface. The diffractive structure(s) provide a plurality of focal lengths for the ophthalmic lens.