Abstract: A high-intensity pulsed-electrical-field (HIPEF) apparatus chemically induces lysis of ocular tissue within a localized portion of an eye. Instead of broadly applying a lysis affecting solution (e.g., plasmin) to the eye, the apparatus delivers solution to only a portion of the eye. The apparatus then alters the effectiveness of at least some of the solution delivered by applying a HIPEF to that solution. In some embodiments, for example, the apparatus delivers a solution that does not substantially affect lysis of ocular tissue and then enhances the solution's effectiveness by applying a HIPEF. As the apparatus applies the HIPEF with high precision, the HIPEF only enhances the effectiveness of the solution within select and localized portions of the eye. The apparatus is especially advantageous for vitreoretinal surgery, whereby the apparatus may selectively induce lysis of vitreous tissue within a localized portion of the vitreous cavity, without significantly affecting adjacent retinal tissue.

Abstract: RNA interference is provided for inhibition of tumor necrosis factor ? (TNF?) by silencing TNF? cell surface receptor TNF receptor-1 (TNFR1) mRNA expression, or by silencing TNF? converting enzyme (TACE/ADAM17) mRNA expression. Silencing such TNF? targets, in particular, is useful for treating patients having a TNF?-related condition or at risk of developing a TNF?-related condition such as the ocular conditions associated with elevated intraocular pressure (IOP), including glaucoma and ocular hypertension.

Abstract: Embodiments of the present invention provide a system and method for detecting the level of a fluid in a surgical cassette by projecting light from a linear light source into a wall of a cassette. Depending on the amount a light reflected or refracted in the cassette (i.e., due to the cassette material/fluid interface or cassette material/air interface (or other interface)) various portions of a linear sensor array will be more or less illuminated. By examining the illumination of the linear sensor array, the level of fluid in the chamber can be determined.

Abstract: A system for positioning an eye of a patient, for example, for laser ophthalmic surgery includes a reflectometer adapted to receive as input a reflected beam from an anterior surface of a cornea of an eye of a patient. The interferometer is calibratable to a desired position of the corneal anterior surface. A comparator is in signal communication with the interferometer and is adapted to calculate from the input a difference between an actual position and the desired position of the corneal anterior surface. A device is in signal communication with the comparator for moving the patient a distance in a direction for matching the actual position to the desired position of the corneal anterior surface.

Abstract: The topical use of 5,6,7-trihydroxyheptanoic acid and analogs are disclosed for the treatment of dry eye disorders and uveitis.

Abstract: A tip wrench/coupler having a generally hollow body for the storage and/or attachment of a tip, and a plurality of fluidic couplers that allow the wrench/coupler to connect two or more handpiece together in series, fluidically, thereby allowing the handpieces to be primed at the same time.

Abstract: RNA interference is provided for inhibition of ocular hypertension target mRNA expression for lowering elevated intraocular pressure in patients with open-angle glaucoma or ocular hypertension. Ocular hypertension targets include carbonic anhydrase II, IV, and XII; ?1- and ?2 adrenergic receptors; acetylcholinesterase; Na+/K+-ATPase; and Na—K-2Cl cotransporter. Ocular hypertension is treated by administering interfering RNAs of the present invention.

Abstract: The present invention relates to methods for disinfecting or cleaning a contact lens comprising contacting a contact lens with a formulation comprising a N-halogenated amino acid and a phase transfer agent for a time sufficient to disinfect or clean the lens. This specification further discloses a formulation for disinfecting a contact lens comprising an N-halogenated amino acid and a phase transfer agent.

Abstract: RNA interference is provided for inhibition of Frizzled Related Protein-1 mRNA expression, in particular, for treating patients having glaucoma or at risk of developing glaucoma.

Abstract: Ophthalmic compositions suitable for use as artificial tears or as vehicles for ophthalmic drugs are disclosed. The compositions contain a combination of two polymers that have a synergistic effect on viscosity.

Abstract: UV absorbing monomers that are particularly useful in ophthalmic devices are disclosed.

Abstract: The present invention relates to an universal antibody acceptor framework and to methods for grafting non-human antibodies, e.g., rabbit antibodies, using a universal antibody acceptor framework. Antibodies generated by the methods of the invention are useful in a variety of diagnostic and therapeutic applications.

Abstract: A high-intensity pulsed electric field (HIPEF) vitrectomy apparatus is disclosed. An exemplary apparatus includes a HIPEF probe comprising at least one electrode disposed at a distal end of the HIPEF probe, such that the distal end is configured for insertion into an eye. A load detection circuit is coupled to the HIPEF probe and is configured to compare a measured physical parameter to a corresponding threshold value. A control circuit is electrically coupled to the load detection circuit and configured to selectively disable application of pulsed energy to the at least one electrode of the HIPEF probe, based on the comparison. The measured physical parameter may include, for example, resistivity, permittivity, reflected light, pressure, or heat dissipation capability.

Abstract: A capsulorhexis apparatus is disclosed. An exemplary apparatus includes a cutting electrode device that in turn comprises a handle, a flexible ring having a single ring-shaped wire electrode embedded therein, and a shaft connecting the flexible ring to the handle, wherein the flexible ring is configured for insertion into an eye through an incision.

Abstract: An eye surgery apparatus includes a HIPEF probe comprising at least two electrodes and is configured for delivery of a high-intensity pulsed electrical field to a surgical site within an eye via the electrodes. Embodiments also include a transducer configured to monitor one or more surgical parameters within the eye during application of the high-intensity pulsed electrical field to the surgical site, a pulse generation circuit configured to generate a series of electrical pulses for application to the electrodes to create the high-intensity pulsed electrical field, and a control circuit, operatively connected to the at least one transducer and the pulse generation circuit and configured to automatically adjust one or more characteristics of the series of electrical pulses, based on the one or more monitored surgical parameters. With these apparatus, the amount of energy delivered can be limited to levels necessary for effective operation without over-exposing the vitreous.

Abstract: Drug delivery devices, and methods of delivering pharmaceutically active agents to a target tissue within a body using such devices, are disclosed. One drug delivery device includes a body having an internal surface for disposing on a target tissue and a well having an opening to the internal surface. An inner core comprising a drug containing portion and an expandable material is disposed in the well.

Abstract: A method and system for measuring an optical property of a multi-focal lens are disclosed. One embodiment of the method comprises: filtering out light transmitted by all but one of a plurality of diffraction orders of the lens to provide an unfiltered light from a single diffraction order; receiving the unfiltered light at a wavefront detector; and analyzing the unfiltered light at the wavefront detector to measure the optical property. The multi-focal lens can be a multi-focal diffractive intra-ocular lens. The measured optical property can be a discontinuity in the lens surface. Filtering can comprise blocking all but the unfiltered light using an aperture operable to let through the unfiltered light from the single diffraction order, and/or blocking all but the unfiltered light using an opaque obstruction operable to let through only a selected amount of light corresponding to the light transmitted by the single diffraction order.

Abstract: A graphical user interface for use in phacoemulsification surgical systems that allows a user to select different pulse modes by touching portions of the display screen. The user interface includes first and second display elements. One display element includes a representation of the on-time of the pulses, and the other display element includes a representation of the off-time. The representations show how the on-time and off-time change relative to a position of a controller, such as a foot pedal. The representation show a constant time, or that a time increases or decreases as the foot pedal is pressed. To select a pulse mode, a user can scroll through different pulse representations by touching the screen at the display elements. The selected pulse mode can be continuous, pulse, burst and other modes.

Abstract: A fluid chamber having an inlet and an outlet at the top of the chamber. The inlet is arrange so that fluid entering the chamber at the inlet sweeps the top of the chamber so as to direct any air bubbles naturally collecting at the top of the chamber or which may be trapped in the entering fluid stream toward the outlet.

Abstract: The present invention provides improved dietary supplements and methods for alleviating the symptoms of dry eye. The dietary supplements of the invention contain omega-3 fatty acids and flavonoids.