Patents Assigned to ALCYONE LIFESCIENCES, INC.
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Publication number: 20180193595Abstract: Systems and methods are disclosed herein that generally involve CED devices with various features for reducing or preventing backflow. In some embodiments, CED devices include a tissue-receiving space disposed proximal to a distal fluid outlet. Tissue can be compressed into or pinched/pinned by the tissue-receiving space as the device is inserted into a target region of a patient, thereby forming a seal that reduces or prevents proximal backflow of fluid ejected from the outlet beyond the tissue-receiving space. In some embodiments, CED devices include a bullet-shaped nose proximal to a distal fluid outlet. The bullet-shaped nose forms a good seal with surrounding tissue and helps reduce or prevent backflow of infused fluid.Type: ApplicationFiled: September 20, 2017Publication date: July 12, 2018Applicant: ALCYONE LIFESCIENCES, INC.Inventors: Deep Arjun Singh, PJ Anand, Blake Sama
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Publication number: 20180185058Abstract: Drug delivery systems and methods are disclosed herein. In some embodiments, a drug delivery system can be configured to deliver a drug to a patient in coordination with a physiological parameter of the patient (e.g., the patient's natural cerebrospinal fluid (CSF) pulsation or the patient's heart or respiration rate). In some embodiments, a drug delivery system can be configured to use a combination of infusion and aspiration to control delivery of a drug to a patient. Catheters, controllers, and other components for use in the above systems are also disclosed, as are various methods of using such systems.Type: ApplicationFiled: December 21, 2017Publication date: July 5, 2018Applicant: Alcyone Lifesciences, Inc.Inventors: PJ Anand, Morgan Brophy, Deep Arjun Singh, Greg Eberl, Ayesha Arzumand, Stela Moura
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Publication number: 20180104459Abstract: Systems and methods for flushing shunt systems are disclosed herein. In some embodiments, a flusher includes a pinch tube that extends over a flush dome such that a user can simultaneously close the pinch tube and actuate the flush dome with a single motion. Flushing and refill valves of the system can be disposed in a cartridge that is laterally-offset from the flush dome, advantageously reducing the height profile of the flusher. Flushers with integrated shunt valves are also disclosed, as are shunt systems with restricted and unrestricted modes for selectively limiting the instances in which a user can open an auxiliary flow path through the system.Type: ApplicationFiled: October 12, 2017Publication date: April 19, 2018Applicant: Alcyone Lifesciences, Inc.Inventors: PJ Anand, Deep Arjun Singh, Greg Eberl, Andrew East, Morgan Brophy, Ayesha Arzumand, Stela Moura, Loredana Guseila
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Patent number: 9919129Abstract: Systems and methods are disclosed herein that generally involve CED devices with various features for reducing or preventing backflow. In some embodiments, CED devices include a tissue-receiving space disposed proximal to a distal fluid outlet. Tissue can be compressed into or pinched/pinned by the tissue-receiving space as the device is inserted into a target region of a patient, thereby forming a seal that reduces or prevents proximal backflow of fluid ejected from the outlet beyond the tissue-receiving space. In some embodiments, CED devices include a bullet-shaped nose proximal to a distal fluid outlet. The bullet-shaped nose forms a good seal with surrounding tissue and helps reduce or prevent backflow of infused fluid.Type: GrantFiled: December 18, 2013Date of Patent: March 20, 2018Assignee: Alcyone Lifesciences, Inc.Inventors: Deep Arjun Singh, PJ Anand, Blake Sama
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Publication number: 20180064919Abstract: Systems and methods are provided herein that generally involve shunting fluid, e.g., shunting cerebrospinal fluid in the treatment of hydrocephalus. Self-cleaning catheters are provided which include split tips configured such that pulsatile flow of fluid in a cavity in which the catheter is inserted can cause the tips to strike one another and thereby clear obstructions. Catheters with built-in flow indicators are also provided. Exemplary flow indicators include projections that extend radially inward from the interior surface of the catheter and which include imageable portions (e.g., portions which are visible under magnetic resonance imaging (MRI)). Movement of the flow indicators caused by fluid flowing through the catheter can be detected using MRI, thereby providing a reliable indication as to whether the catheter is partially or completely blocked.Type: ApplicationFiled: July 20, 2017Publication date: March 8, 2018Applicant: Alcyone Lifesciences, Inc.Inventors: Andrew East, Morgan Brophy, Deep Arjun Singh, PJ Anand, Robert Degon, Timothy Fallon, Allison Waller, Matthew Attar
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Publication number: 20180028761Abstract: Automated drug delivery systems and related methods are disclosed herein. In some embodiments, these systems can reduce or eliminate infusion inconsistencies. An exemplary system can include a syringe actuator which can be controlled via electrical, mechanical, pneumatic, and/or hydraulic means to precisely infuse and/or withdraw material from a patient.Type: ApplicationFiled: July 28, 2017Publication date: February 1, 2018Applicant: Alcyone Lifesciences, Inc.Inventors: PJ Anand, Ayesha Arzumand, Morgan Brophy, Andrew East, Gregory Eberl, Deep Arjun Singh
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Publication number: 20170348513Abstract: Drug delivery devices and methods are disclosed herein. In some embodiments, a drug can be delivered into a brain ventricle of a subject, where it can diffuse, flow, or otherwise travel across the ependyma and into the hippocampus. The drug can be delivered through a delivery device configured to selectively or transiently obstruct a portion of the ventricle, e.g., the temporal horn or a posterior portion of the temporal horn. The obstruction can define a partitioned volume of the ventricle, limiting or preventing flow of cerebrospinal fluid (CSF) into or out of the partitioned volume. Accordingly, a drug can be delivered into the partitioned volume without being diluted or carried away by CSF, allowing the drug to saturate the ependyma adjacent the hippocampus.Type: ApplicationFiled: June 2, 2017Publication date: December 7, 2017Applicant: Alcyone Lifesciences, Inc.Inventors: Eric Leuthardt, PJ Anand
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Publication number: 20170258996Abstract: Drug delivery systems and methods are disclosed herein. In some embodiments, a drug delivery system can be configured to deliver a drug to a patient in coordination with a physiological parameter of the patient (e.g., the patient's natural cerebrospinal fluid (CSF) pulsation or the patient's heart or respiration rate). In some embodiments, a drug delivery system can be configured to use a combination of infusion and aspiration to control delivery of a drug to a patient. Catheters, controllers, and other components for use in the above systems are also disclosed, as are various methods of using such systems.Type: ApplicationFiled: May 25, 2017Publication date: September 14, 2017Applicant: Alcyone Lifesciences, Inc.Inventors: PJ Anand, Morgan Brophy, Deep Arjun Singh, Greg Eberl
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Patent number: 9744338Abstract: Systems and methods are provided herein that generally involve shunting fluid, e.g., shunting cerebrospinal fluid in the treatment of hydrocephalus. Self-cleaning catheters are provided which include split tips configured such that pulsatile flow of fluid in a cavity in which the catheter is inserted can cause the tips to strike one another and thereby clear obstructions. Catheters with built-in flow indicators are also provided. Exemplary flow indicators include projections that extend radially inward from the interior surface of the catheter and which include imageable portions (e.g., portions which are visible under magnetic resonance imaging (MRI)). Movement of the flow indicators caused by fluid flowing through the catheter can be detected using MRI, thereby providing a reliable indication as to whether the catheter is partially or completely blocked.Type: GrantFiled: April 18, 2015Date of Patent: August 29, 2017Assignee: Alcyone Lifesciences, Inc.Inventors: Andrew East, Morgan Brophy, Deep Arjun Singh, P J Anand, Robert Degon, Timothy Fallon, Allison Waller, Matthew Attar
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Publication number: 20170189656Abstract: Systems and methods are provided herein that generally involve shunting fluid, e.g., shunting cerebrospinal fluid in the treatment of hydrocephalus. Self-cleaning catheters are provided which include split tips configured such that pulsatile flow of fluid in a cavity in which the catheter is inserted can cause the tips to strike one another and thereby clear obstructions. Catheters with built-in flow indicators are also provided. Exemplary flow indicators include projections that extend radially inward from the interior surface of the catheter and which include imageable portions (e.g., portions which are visible under magnetic resonance imaging (MRI)). Movement of the flow indicators caused by fluid flowing through the catheter can be detected using MRI, thereby providing a reliable indication as to whether the catheter is partially or completely blocked.Type: ApplicationFiled: March 17, 2017Publication date: July 6, 2017Applicant: Alcyone Lifesciences, Inc.Inventors: PJ Anand, Deep Arjun Singh, Morgan Brophy, Timothy Fallon, Robert Degon, Matthew Attar, Anthony Wong, Allison Waller, Andrew East, Jon T. McIntyre
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Publication number: 20170189040Abstract: Methods and devices are disclosed herein that allow for infusion and aspiration through a single device. The device can be used to treat a stroke by delivering the device to the site of a blood clot and simultaneously or sequentially infusing a thrombolytic or other drug into the clot and aspirating the dissolving clot from the patient. The methods and devices can advantageously permit more efficient thrombolytic infusion and clot aspiration. Modular systems are also disclosed, as are methods of treating subdural hematoma or other conditions.Type: ApplicationFiled: January 4, 2017Publication date: July 6, 2017Applicant: Alcyone Lifesciences, Inc.Inventors: PJ Anand, John Ekholm, Deep Arjun Singh
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Patent number: 9682193Abstract: Drug delivery systems and methods are disclosed herein. In some embodiments, a drug delivery system can be configured to deliver a drug to a patient in coordination with a physiological parameter of the patient (e.g., the patient's natural cerebrospinal fluid (CSF) pulsation or the patient's heart or respiration rate). In some embodiments, a drug delivery system can be configured to use a combination of infusion and aspiration to control delivery of a drug to a patient. Catheters, controllers, and other components for use in the above systems are also disclosed, as are various methods of using such systems.Type: GrantFiled: May 11, 2016Date of Patent: June 20, 2017Assignee: Alcyone Lifesciences, Inc.Inventors: PJ Anand, Morgan Brophy, Deep Arjun Singh, Greg Eberl
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Publication number: 20160331897Abstract: Drug delivery systems and methods are disclosed herein. In some embodiments, a drug delivery system can be configured to deliver a drug to a patient in coordination with a physiological parameter of the patient (e.g., the patient's natural cerebrospinal fluid (CSF) pulsation or the patient's heart or respiration rate). In some embodiments, a drug delivery system can be configured to use a combination of infusion and aspiration to control delivery of a drug to a patient. Catheters, controllers, and other components for use in the above systems are also disclosed, as are various methods of using such systems.Type: ApplicationFiled: May 11, 2016Publication date: November 17, 2016Applicant: Alcyone Lifesciences, Inc.Inventors: PJ Anand, Morgan Brophy, Deep Arjun Singh, Greg Eberl
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Patent number: 9433764Abstract: Systems and methods are provided herein that generally involve shunting fluid, e.g., shunting cerebrospinal fluid in the treatment of hydrocephalus. Self-cleaning catheters are provided which include split tips configured such that pulsatile flow of fluid in a cavity in which the catheter is inserted can cause the tips to strike one another and thereby clear obstructions. Catheters with built-in flow indicators are also provided. Exemplary flow indicators include projections that extend radially inward from the interior surface of the catheter and which include imageable portions (e.g., portions which are visible under magnetic resonance imaging (MRI)). Movement of the flow indicators caused by fluid flowing through the catheter can be detected using MRI, thereby providing a reliable indication as to whether the catheter is partially or completely blocked.Type: GrantFiled: June 16, 2015Date of Patent: September 6, 2016Assignee: Alcyone Lifesciences, Inc.Inventors: Andrew East, Morgan Brophy, Deep Arjun Singh, PJ Anand, Robert Degon, Timothy Fallon, Allison Waller, Matthew Attar
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Publication number: 20160213312Abstract: Systems and methods for delivering a drug with a tracer or contrast agent are disclosed herein, as are systems and methods that generally involve CED devices with various features for reducing or preventing backflow. In some embodiments, CED devices include a tissue-receiving space disposed proximal to a distal fluid outlet. Tissue can be compressed into or pinched/pinned by the tissue-receiving space as the device is inserted into a target region of a patient, thereby forming a seal that reduces or prevents proximal backflow of fluid ejected from the outlet beyond the tissue-receiving space. In some embodiments, CED devices include a bullet-shaped nose proximal to a distal fluid outlet. The bullet-shaped nose forms a good seal with surrounding tissue and helps reduce or prevent backflow of infused fluid.Type: ApplicationFiled: January 26, 2015Publication date: July 28, 2016Applicant: ALCYONE LIFESCIENCES, INC.Inventors: Deep Arjun Singh, PJ Anand, Martin Lee Brady
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Publication number: 20150367110Abstract: Systems and methods are provided herein that generally involve shunting fluid, e.g., shunting cerebrospinal fluid in the treatment of hydrocephalus. Self-cleaning catheters are provided which include split tips configured such that pulsatile flow of fluid in a cavity in which the catheter is inserted can cause the tips to strike one another and thereby clear obstructions. Catheters with built-in flow indicators are also provided. Exemplary flow indicators include projections that extend radially inward from the interior surface of the catheter and which include imageable portions (e.g., portions which are visible under magnetic resonance imaging (MRI)). Movement of the flow indicators caused by fluid flowing through the catheter can be detected using MRI, thereby providing a reliable indication as to whether the catheter is partially or completely blocked.Type: ApplicationFiled: June 16, 2015Publication date: December 24, 2015Applicant: ALCYONE LIFESCIENCES, INC.Inventors: Andrew East, Morgan Brophy, Deep Arjun Singh, PJ Anand, Robert Degon, Timothy Fallon, Allison Waller, Matthew Attar
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Publication number: 20150297874Abstract: Systems and methods are provided herein that generally involve shunting fluid, e.g., shunting cerebrospinal fluid in the treatment of hydrocephalus. Self-cleaning catheters are provided which include split tips configured such that pulsatile flow of fluid in a cavity in which the catheter is inserted can cause the tips to strike one another and thereby clear obstructions. Catheters with built-in flow indicators are also provided. Exemplary flow indicators include projections that extend radially inward from the interior surface of the catheter and which include imageable portions (e.g., portions which are visible under magnetic resonance imaging (MRI)). Movement of the flow indicators caused by fluid flowing through the catheter can be detected using MRI, thereby providing a reliable indication as to whether the catheter is partially or completely blocked.Type: ApplicationFiled: April 18, 2015Publication date: October 22, 2015Applicant: ALCYONE LIFESCIENCES, INC.Inventors: Andrew East, Morgan Brophy, Deep Arjun Singh, PJ Anand, Robert Degon, Timothy Fallon, Allison Waller, Matthew Attar
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Patent number: 8992458Abstract: Systems and methods are disclosed herein that generally involve CED devices with various features for reducing or preventing backflow. In some embodiments, CED devices include a tissue-receiving space disposed proximal to a distal fluid outlet. Tissue can be compressed into or pinched/pinned by the tissue-receiving space as the device is inserted into a target region of a patient, thereby forming a seal that reduces or prevents proximal backflow of fluid ejected from the outlet beyond the tissue-receiving space. In some embodiments, CED devices include a bullet-shaped nose proximal to a distal fluid outlet. The bullet-shaped nose forms a good seal with surrounding tissue and helps reduce or prevent backflow of infused fluid.Type: GrantFiled: December 18, 2013Date of Patent: March 31, 2015Assignee: Alcyone Lifesciences, Inc.Inventors: Deep Arjun Singh, PJ Anand
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Publication number: 20150038949Abstract: Systems and methods for delivering a drug or other therapy over an extended period of time (e.g., several hours, days, weeks, months, years, and so forth) are disclosed herein, as are systems and methods for monitoring various parameters associated with the treatment of a patient. Systems and methods are also disclosed herein that generally involve CED devices with various features for reducing or preventing backflow.Type: ApplicationFiled: July 31, 2014Publication date: February 5, 2015Applicant: Alcyone Lifesciences, Inc.Inventors: Deep Arjun Singh, PJ Anand, Andrew East
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Publication number: 20140207043Abstract: Systems and methods are provided herein that generally involve shunting fluid, e.g., shunting cerebrospinal fluid in the treatment of hydrocephalus. Self-cleaning catheters are provided which include split tips configured such that pulsatile flow of fluid in a cavity in which the catheter is inserted can cause the tips to strike one another and thereby clear obstructions. Catheters with built-in flow indicators are also provided. Exemplary flow indicators include projections that extend radially inward from the interior surface of the catheter and which include imageable portions (e.g., portions which are visible under magnetic resonance imaging (MRI)). Movement of the flow indicators caused by fluid flowing through the catheter can be detected using MRI, thereby providing a reliable indication as to whether the catheter is partially or completely blocked.Type: ApplicationFiled: January 22, 2014Publication date: July 24, 2014Applicant: ALCYONE LIFESCIENCES, INC.Inventors: PJ Anand, Deep Arjun Singh