Abstract: An adhesive composition described herein comprises an aqueous solvent; and a population of first nanoparticles dispersed in the aqueous solvent, the first nanoparticles comprising a negative or positive charge, and an average size in three dimensions of 1 nm to 1000 nm. In some embodiments, a population of second nanoparticles is dispersed in the aqueous solvent, the second nanoparticles comprises a negative or positive charge opposite the charge of the population of first nanoparticles. In some embodiments, the population of first nanoparticles comprise an average first size in three dimensions, and the population of second nanoparticles comprise an average second size in three dimensions that is different from the average first size of the first nanoparticles.

Abstract: In some embodiments, a film forming composition described herein comprises an aliphatic polyisocyanate; an aliphatic polyfunctional nucleophile; a chain extender; a first solvent; and a second solvent, wherein an evaporation rate of the first solvent and an evaporation rate of the second solvent are within 150% of each other, the percentage being based on the larger value. In some embodiments, a method of forming a film on a substrate is described herein, the method comprising combining a polyisocyanate with a polyol to form a polyurethane pre-polymer; combining the polyurethane pre-polymer with a chain extender to form a polymer; and applying the polymer to the substrate.

Abstract: The present disclosure is directed to an injectable composition in form of fluid gel and the use thereof to assist the tissues resection during endoscopic procedures in which it is injected in the tissue of interest to form a cushion for tissue separation. Aspects of the composition can include a gelling agent, a modifier, a salt and water. The composition can be prepared by mixing the gelling agent, modifier, at least one salt and water via continuous stirring to obtain fluid gel solutions, wherein modifier enables the said fluid gel composition to be injected into the submucosal layer of gastrointestinal tissues through endoscopic injection catheter and needle with significantly reduced injection pressure and generate a high and durable cushion for long-lasting tissue raise-up in the submucosal layer, for the application of injection assisted resection procedures.

Abstract: Crosslinked biodegradable block polyurethane copolymers prepared from a plurality of biodegradable polymers or oligomers linked together via urethane bonds and crosslinked via a citrate ester are disclosed. Such copolymers can include folic acid and fabricated into medical devices such as a nerve growth conduit and locally deliver folic acid to a site of injury such as a PNS injury site.

Abstract: In one aspect, the present disclosure relates to click-functional antimicrobial molecules (including small molecules or, in some cases, macromolecules) and the construction of antimicrobial polymers such as polyurethanes, polyesters, and polyacrylates, including through the use of such molecules. In some cases, the antimicrobial click-functional molecules are based on 1,2-benzisothiazolin-3-one (BIT), trimethylguanidine or tetramethylguanidine (TMG), polyhexamethylene guanidine (PHMG), fluorine-containing molecules, or a combination thereof. For example, 1,2-benzisothiazolin-3-one (BIT) functionalized with an alkyne (BIT-Al), trimethylguanidine or tetramethylguanidine (TMG) functioned with an alkyne (TMG-Al) or dual alkynes (TMG-dAl), and/or polyhexamethylene guanidine (PHMG) functionalized with an alkyne (PHMG-Al) are described herein. Clickable antimicrobial polymers can be used to form coatings or films.